John Wiley & Sons Limited
Все книги издательства John Wiley & Sons LimitedSuccess Probability Estimation with Applications to Clinical Trials
Provides an introduction to the various statistical techniques involved in medical research and drug development with a focus on estimating the success probability of an experiment Success Probability Estimation with Applications to Clinical Trials details the use of success probability estimation in both the planning and analyzing of clinical trials and in widely used statistical tests. Devoted to both statisticians and non-statisticians who are involved in clinical trials, Part I of the book presents new concepts related to success probability estimation and their usefulness in clinical trials, and each section begins with a non-technical explanation of the presented concepts. Part II delves deeper into the techniques for success probability estimation and features applications to both reproducibility probability estimation and conservative sample size estimation. Success Probability Estimation with Applications to Clinical Trials: • Addresses the theoretical and practical aspects of the topic and introduces new and promising techniques in the statistical and pharmaceutical industries Features practical solutions for problems that are often encountered in clinical trials Includes success probability estimation for widely used statistical tests, such as parametric and nonparametric models Focuses on experimental planning, specifically the sample size of clinical trials using phase II results and data for planning phase III trials Introduces statistical concepts related to success probability estimation and their usefulness in clinical trials Success Probability Estimation with Applications to Clinical Trials is an ideal reference for statisticians and biostatisticians in the pharmaceutical industry as well as researchers and practitioners in medical centers who are actively involved in health policy, clinical research, and the design and evaluation of clinical trials.
Financial Risk Modelling and Portfolio Optimization with R
Introduces the latest techniques advocated for measuring financial market risk and portfolio optimization, and provides a plethora of R code examples that enable the reader to replicate the results featured throughout the book. Financial Risk Modelling and Portfolio Optimization with R: Demonstrates techniques in modelling financial risks and applying portfolio optimization techniques as well as recent advances in the field. Introduces stylized facts, loss function and risk measures, conditional and unconditional modelling of risk; extreme value theory, generalized hyperbolic distribution, volatility modelling and concepts for capturing dependencies. Explores portfolio risk concepts and optimization with risk constraints. Enables the reader to replicate the results in the book using R code. Is accompanied by a supporting website featuring examples and case studies in R. Graduate and postgraduate students in finance, economics, risk management as well as practitioners in finance and portfolio optimization will find this book beneficial. It also serves well as an accompanying text in computer-lab classes and is therefore suitable for self-study.
Statistical Thinking for Non-Statisticians in Drug Regulation
Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides non-statisticians working in the pharmaceutical and medical device industries with an accessible introduction to the knowledge they need when working with statistical information and communicating with statisticians. It covers the statistical aspects of design, conduct, analysis and presentation of data from clinical trials in drug regulation and improves the ability to read, understand and critically appraise statistical methodology in papers and reports. As such, it is directly concerned with the day-to-day practice and the regulatory requirements of drug development and clinical trials. Fully conversant with current regulatory requirements, this second edition includes five new chapters covering Bayesian statistics, adaptive designs, observational studies, methods for safety analysis and monitoring and statistics for diagnosis. Authored by a respected lecturer and consultant to the pharmaceutical industry, Statistical Thinking for Non-Statisticians in Drug Regulation is an ideal guide for physicians, clinical research scientists, managers and associates, data managers, medical writers, regulatory personnel and for all non-statisticians working and learning within the pharmaceutical industry.
Using LEDs, LCDs and GLCDs in Microcontroller Projects
Describing the use of displays in microcontroller based projects, the author makes extensive use of real-world, tested projects. The complete details of each project are given, including the full circuit diagram and source code. The author explains how to program microcontrollers (in C language) with LED, LCD and GLCD displays; and gives a brief theory about the operation, advantages and disadvantages of each type of display. Key features: Covers topics such as: displaying text on LCDs, scrolling text on LCDs, displaying graphics on GLCDs, simple GLCD based games, environmental monitoring using GLCDs (e.g. temperature displays) Uses C programming throughout the book – the basic principles of programming using C language and introductory information about PIC microcontroller architecture will also be provided Includes the highly popular PIC series of microcontrollers using the medium range PIC18 family of microcontrollers in the book. Provides a detailed explanation of Visual GLCD and Visual TFT with examples. Companion website hosting program listings and data sheets Contains the extensive use of visual aids for designing LED, LCD and GLCD displays to help readers to understand the details of programming the displays: screen-shots, tables, illustrations, and figures, as well as end of chapter exercises Using LEDs, LCDS, and GLCDs in Microcontroller Projects is an application oriented book providing a number of design projects making it practical and accessible for electrical & electronic engineering and computer engineering senior undergraduates and postgraduates. Practising engineers designing microcontroller based devices with LED, LCD or GLCD displays will also find the book of great use.
Frequently Asked Questions on Anti-Bribery and Corruption
A practical guide to addressing the challenges managers face in implementing and enforcing new anti-bribery regulations The Bribery Act became the law of the land in July 2011. It abolished all existing U.K. anti-bribery laws and replaced them with a suite of new regulations decidedly different and more strenuous than what has come before. Under it companies found noncompliant will be open to billions in penalties and remediation costs, and managers will be open to prosecution if anyone associated with their company commits an offence covered by the act. As employees in nearly all departments will share responsibility for ensuring that adequate procedures are in place and enforced, there is a screaming need for practical, jargon-free guidance on the subject. This book fills that need. It arms managers and advisors with the knowledge and tools they need to implement, communicate and test controls and procedures that not only comply with but exceed the new anti-bribery requirements. It also offers priceless pointers on how to effectively react to bribery allegations if and when they occur. Packed with takeaway tips and checklists that put crucial information at readers' fingertips Written by a chartered accountant and compliance expert, the book offers practical steps managers should take to guarantee company compliance Describes best practices in anti-bribery and corruption compliance in all key business areas, including accounting, sales and marketing, management, legal, and internal auditing
Nanometer Frequency Synthesis Beyond the Phase-Locked Loop
Introducing a new, pioneering approach to integrated circuit design Nanometer Frequency Synthesis Beyond Phase-Locked Loop introduces an innovative new way of looking at frequency that promises to open new frontiers in modern integrated circuit (IC) design. While most books on frequency synthesis deal with the phase-locked loop (PLL), this book focuses on the clock signal. It revisits the concept of frequency, solves longstanding problems in on-chip clock generation, and presents a new time-based information processing approach for future chip design. Beginning with the basics, the book explains how clock signal is used in electronic applications and outlines the shortcomings of conventional frequency synthesis techniques for dealing with clock generation problems. It introduces the breakthrough concept of Time-Average-Frequency, presents the Flying-Adder circuit architecture for the implementation of this approach, and reveals a new circuit device, the Digital-to-Frequency Converter (DFC). Lastly, it builds upon these three key components to explain the use of time rather than level to represent information in signal processing. Provocative, inspiring, and chock-full of ideas for future innovations, the book features: A new way of thinking about the fundamental concept of clock frequency A new circuit architecture for frequency synthesis: the Flying-Adder direct period synthesis A new electronic component: the Digital-to-Frequency Converter A new information processing approach: time-based vs. level-based Examples demonstrating the power of this technology to build better, cheaper, and faster systems Written with the intent of showing readers how to think outside the box, Nanometer Frequency Synthesis Beyond the Phase-Locked Loop is a must-have resource for IC design engineers and researchers as well as anyone who would like to be at the forefront of modern circuit design.
Rotating Thermal Flows in Natural and Industrial Processes
Rotating Thermal Flows in Natural and Industrial Processes provides the reader with a systematic description of the different types of thermal convection and flow instabilities in rotating systems, as present in materials, crystal growth, thermal engineering, meteorology, oceanography, geophysics and astrophysics. It expressly shows how the isomorphism between small and large scale phenomena becomes beneficial to the definition and ensuing development of an integrated comprehensive framework. This allows the reader to understand and assimilate the underlying, quintessential mechanisms without requiring familiarity with specific literature on the subject. Topics treated in the first part of the book include: • Thermogravitational convection in rotating fluids (from laminar to turbulent states); • Stably stratified and unstratified shear flows; • Barotropic and baroclinic instabilities; • Rossby waves and Centrifugally-driven convection; • Potential Vorticity, Quasi-Geostrophic Theory and related theorems; • The dynamics of interacting vortices, interacting waves and mixed (hybrid) vortex-wave states; • Geostrophic Turbulence and planetary patterns. The second part is entirely devoted to phenomena of practical interest, i.e. subjects relevant to the realms of industry and technology, among them: • Surface-tension-driven convection in rotating fluids; • Differential-rotation-driven (forced) flows; • Crystal Growth from the melt of oxide or semiconductor materials; • Directional solidification; • Rotating Machinery; • Flow control by Rotating magnetic fields; • Angular Vibrations and Rocking motions; Covering a truly prodigious range of scales, from atmospheric and oceanic processes and fluid motion in “other solar-system bodies”, to convection in its myriad manifestations in a variety of applications of technological relevance, this unifying text is an ideal reference for physicists and engineers, as well as an important resource for advanced students taking courses on the physics of fluids, fluid mechanics, thermal, mechanical and materials engineering, environmental phenomena, meteorology and geophysics.
Clinical Case Studies for the Family Nurse Practitioner
Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.
Practical Guide to Diagnosing Structural Movement in Buildings
What's the Crack? When cracking is observed in a building the most common reaction is that it must be the foundations and that it must be serious. Many surveyors are nervous about diagnosing cracks. This is understandable, as the interpretation of cracks can be difficult to teach, with university courses providing little or no time for field experience. Yet by understanding one straightforward principle the majority of cracks can be diagnosed in just a few minutes. Linking this with a good knowledge of construction techniques, the factors that distort cracking patterns and the key features of common causes of cracking, almost all cracks can be diagnosed quickly and with confidence. Practical Guide to Diagnosing Structural Movement in Buildings provides a methodology by which cracks and movement in buildings can be diagnosed. Written in four parts, part one describes the key principles of movement and cracking. Parts two and three describe the main features of common forms of movement and the associated crack patterns. Part two covers causes other than ground or foundation movement and part three covers movement caused by ground or foundation problems. Part four briefly describes the techniques used to arrest further movement or repair damage cause by movement. Primarily intended for the relatively inexperienced surveyor or engineer and undergraduate students of surveying as a practical guide for use on site, it focuses on identification and diagnosis. It will not only help in correctly diagnosing the problem but it will also demonstrate a methodical approach to show and record how the diagnosis was reached – critical when giving advice to third parties. «What's the crack?» – In the vast majority of cases it's not foundation related and in most cases it's not indicating a serious defect.
Permanent Magnet Brushless DC Motor Drives and Controls
An advanced introduction to the simulation and hardware implementation of BLDC motor drives A thorough reference on the simulation and hardware implementation of BLDC motor drives, this book covers recent advances in the control of BLDC motor drives, including intelligent control, sensorless control, torque ripple reduction and hardware implementation. With the guidance of the expert author team, readers will understand the principle, modelling, design and control of BLDC motor drives. The advanced control methods and new achievements of BLDC motor drives, of interest to more advanced readers, are also presented. Focuses on the control of PM brushless DC motors, giving readers the foundations to the topic that they can build on through more advanced reading Systematically guides readers through the subject, introducing basic operational principles before moving on to advanced control algorithms and implementations Covers special issues, such as sensorless control, intelligent control, torque ripple reduction and hardware implementation, which also have applications to other types of motors Includes presentation files with lecture notes and Matlab 7 coding on a companion website for the book