John Wiley & Sons Limited
Все книги издательства John Wiley & Sons LimitedProteomic Applications in Cancer Detection and Discovery
Helps researchers in proteomics and oncology work together to understand, prevent, and cure cancer Proteomic data is increasingly important to understanding the origin and progression of cancer; however, most oncologic researchers who depend on proteomics for their studies do not collect the data themselves. As a result, there is a knowledge gap between scientists, who devise proteomic techniques and collect the data, and the oncologic researchers, who are expected to interpret and apply proteomic data. Bridging the gap between proteomics and oncology research, this book explains how proteomic technology can be used to address some of the most important questions in cancer research. Proteomic Applications in Cancer Detection and Discovery enables readers to understand how proteomic data is acquired and analyzed and how it is interpreted. Author Timothy Veenstra has filled the book with examples—many based on his own firsthand research experience—that clearly demonstrate the application of proteomic technology in oncology research, including the discovery of novel biomarkers for different types of cancers. The book begins with a brief introduction to systems biology, explaining why cancer is a systems biology disease. Next, it covers such topics as: Mass spectrometry in cancer research Application of proteomics to global phosphorylation analysis Search for biomarkers in biofluids Rise and fall of proteomic patterns for cancer diagnostics Emergence of protein arrays Role of proteomics in personalized medicine The final chapter is dedicated to the future prospects of proteomics in cancer research. By guiding readers through the latest proteomic technologies and their applications in cancer research, Proteomic Applications in Cancer Detection and Discovery enhances the ability of researchers in proteomics and researchers in oncology to collaborate in order to better understand cancer and develop strategies to prevent and treat it.
A Companion to the Antebellum Presidents 1837 - 1861
A Companion to the Antebellum Presidents presents a series of original essays exploring our historical understanding of the role and legacy of the eight U.S. presidents who served in the significant period between 1837 and the start of the Civil War in 1861. Explores and evaluates the evolving scholarly reception of Presidents Van Buren, Harrison, Tyler, Polk, Taylor, Fillmore, Pierce, and Buchanan, including their roles, behaviors, triumphs, and failures Represents the first single-volume reference to gather together the historiographic literature on the Antebellum Presidents Brings together original contributions from a team of eminent historians and experts on the American presidency Reveals insights into presidential leadership in the quarter century leading up to the American Civil War Offers fresh perspectives into the largely forgotten men who served during one of the most decisive quarter centuries of United States history
Handbook of Asynchronous Machines with Variable Speed
This handbook deals with the asynchronous machine in its close environment. It was born from a reflection on this electromagnetic converter whose integration in industrial environments takes a wide part. Previously this type of motor operated at fixed speed, from now on it has been integrated more and more in processes at variable speed. For this reason it seemed useful, or necessary, to write a handbook on the various aspects from the motor in itself, via the control and while finishing by the diagnosis aspect. Indeed, an asynchronous motor is used nowadays in industry where variation speed and reliability are necessary. We must know permanently for the sensitive systems, the state of process and to inform the operator of the appearance of any anomaly and its severity.
Inverse Problems in Vision and 3D Tomography
The concept of an inverse problem is a familiar one to most scientists and engineers, particularly in the field of signal and image processing, imaging systems (medical, geophysical, industrial non-destructive testing, etc.) and computer vision. In imaging systems, the aim is not just to estimate unobserved images, but also their geometric characteristics from observed quantities that are linked to these unobserved quantities through the forward problem. This book focuses on imagery and vision problems that can be clearly written in terms of an inverse problem where an estimate for the image and its geometrical attributes (contours and regions) is sought. The chapters of this book use a consistent methodology to examine inverse problems such as: noise removal; restoration by deconvolution; 2D or 3D reconstruction in X-ray, tomography or microwave imaging; reconstruction of the surface of a 3D object using X-ray tomography or making use of its shading; reconstruction of the surface of a 3D landscape based on several satellite photos; super-resolution; motion estimation in a sequence of images; separation of several images mixed using instruments with different sensitivities or transfer functions; and more.
Operations and Production Systems with Multiple Objectives
The first comprehensive book to uniquely combine the three fields of systems engineering, operations/production systems, and multiple criteria decision making/optimization Systems engineering is the art and science of designing, engineering, and building complex systems—combining art, science, management, and engineering disciplines. Operations and Production Systems with Multiple Objectives covers all classical topics of operations and production systems as well as new topics not seen in any similiar textbooks before: small-scale design of cellular systems, large-scale design of complex systems, clustering, productivity and efficiency measurements, and energy systems. Filled with completely new perspectives, paradigms, and robust methods of solving classic and modern problems, the book includes numerous examples and sample spreadsheets for solving each problem, a solutions manual, and a book companion site complete with worked examples and supplemental articles. Operations and Production Systems with Multiple Objectives will teach readers: How operations and production systems are designed and planned How operations and production systems are engineered and optimized How to formulate and solve manufacturing systems problems How to model and solve interdisciplinary and systems engineering problems How to solve decision problems with multiple and conflicting objectives This book is ideal for senior undergraduate, MS, and PhD graduate students in all fields of engineering, business, and management as well as practitioners and researchers in systems engineering, operations, production, and manufacturing.
Aircraft Systems Integration of Air-Launched Weapons
From the earliest days of aviation where the pilot would drop simple bombs by hand, to the highly agile, stealthy aircraft of today that can deliver smart ordnance with extreme accuracy, engineers have striven to develop the capability to deliver weapons against targets reliably, safely and with precision. Aircraft Systems Integration of Air-Launched Weapons introduces the various aspects of weapons integration, primarily from the aircraft systems integration viewpoint, but also considers key parts of the weapon and the desired interactions with the aircraft required for successful target engagement. Key features: Addresses the broad range of subjects that relate directly to the systems integration of air-launched weapons with aircraft, such as the integration process, system and subsystem architectures, the essential contribution that open, international standards have on improving interoperability and reducing integration costs and timescales Describes the recent history of how industry and bodies such as NATO have driven the need for greater interoperability between weapons and aircraft and worked to reduce the cost and timescales associated with the systems integration of complex air-launched weapons with aircraft Explores future initiatives and technologies relating to the reduction of systems integration costs and timescales The systems integration of air-launched weapons with aircraft requires a multi-disciplinary set of engineering capabilities. As a typical weapons integration life-cycle spans several years, new engineers have to learn the skills required by on-the-job training and working with experienced weapons integrators. Aircraft Systems Integration of Air-Launched Weapons augments hands-on experience, thereby enabling the development of subject matter expertise more quickly and in a broader context than would be achieved by working through the life-cycle on one specific project. This book also serves as a useful revision source for experienced engineers in the field.
Reading the Contemporary Irish Novel 1987-2007
Reading the Contemporary Irish Novel 1987–2007 is the authoritative guide to some of the most inventive and challenging fiction to emerge from Ireland in the last 25 years. Meticulously researched, it presents detailed interpretations of novels by some of Ireland’s most eminent writers. This is the first text-focused critical survey of the Irish novel from 1987 to 2007, providing detailed readings of 11 seminal Irish novels A timely and much needed text in a largely uncharted critical field Provides detailed interpretations of individual novels by some of the country’s most critically celebrated writers, including Sebastian Barry, Roddy Doyle, Anne Enright, Patrick McCabe, John McGahern, Edna O’Brien and Colm Tóibín Investigates the ways in which Irish novels have sought to deal with and reflect a changing Ireland The fruit of many years reading, teaching and research on the subject by a leading and highly respected academic in the field
Plant Transposons and Genome Dynamics in Evolution
The transposable genetic elements, or transposons, as they are now known, have had a tumultuous history. Discovered in the mid-20th century by Barbara McClintock, they were initially received with puzzlement. When their genomic abundance began to be apparent, they were categorized as «junk DNA» and acquired the label of parasites. Expanding understanding of gene and genome organization has revealed the profound extent of their impact on both. Plant Transposons and Genome Dynamics in Evolution captures and distills the voluminous research literature on plant transposable elements and seeks to assemble the big picture of how transposons shape gene structure and regulation, as well as how they sculpt genomes in evolution. Individual chapters provide concise overviews of the many flavors of plant transposons and of their roles in gene creation, gene regulation, development, genome evolution, and organismal speciation, as well as of their epigenetic regulation. This volume is essential reading for anyone working in plant genetics, epigenetics, or evolutionary biology.
A Handbook of English Renaissance Literary Studies
Provides a detailed map of contemporary critical theory in Renaissance and Early Modern English literary studies beyond Shakespeare A Handbook of English Renaissance Literary Studies is a groundbreaking guide to the contemporary engagement with critical theory within the larger disciplinary area of Renaissance and Early Modern studies. Comprising commissioned contributions from leading international scholars, it provides an overview of literary theory, beyond Shakespeare, focusing on most major figures, as well as some lesser-known writers of the period. This book represents an important first step in bridging the divide between the abundance of titles which explore applications of theory in Shakespeare studies, and the relative lack of such texts concerning English Literary Renaissance studies as a whole, which includes major figures such as Marlowe, Jonson, Donne, and Milton. The tripartite structure offers a map of the critical landscape so that students can appreciate the breadth of the work being done, along with an exploration of the ways in which the treatments of or approaches to key issues have changed over time. Handbook of English Renaissance Literary Studies is must-reading for undergraduate and postgraduate students of early modern and Renaissance English literature, as well as their instructors and advisors. Divided into three main sections, “Conditions of Subjectivity,” “Spaces, Places, and Forms,” and “Practices and Theories,” A Handbook of English Renaissance Literary Studies: Provides an overview of theoretical work and the theoretical-informed competencies which are central to the teaching of English Renaissance literary studies beyond Shakespeare Provides a map of the critical landscape of the field to provide students with an opportunity to appreciate the breadth of the work done Features newly-commissioned essays in representative subject areas to offer a clear picture of the contemporary theoretically-engaged work in the field Explores the ways in which the treatments of or approaches to key issues have changed over time Offers examples of the ways in which the practice of a theoretically-engaged criticism may enrich the personal and professional lives of critics, and the culture in which such critical practice takes place
Solutions Manual to accompany Ordinary Differential Equations
Features a balance between theory, proofs, and examples and provides applications across diverse fields of study Ordinary Differential Equations presents a thorough discussion of first-order differential equations and progresses to equations of higher order.