With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.
Not just another standard introduction to neuroanatomy, How the Brain Works is an innovative and fun way to learn about the function and dysfunction of the central nervous system, as explained in nine easy-to-understand «lectures.» This exciting new addition to the «How it Works» series does away with the use of exhaustive details and tedious definitions to provide an understandable and scientifically sound overview of the human brain. This book is neither an outline nor a summary, but an informal approach to the relationship between physiology and manifest behavior, including all essential elements covered in most courses. Students will find this book to be the perfect introduction to their neuroscience courses, as well as a quick review for exam. Professionals will enjoy the way in which this complex topic is addressed in a simple and straightforward manner, and the general reader will satisfy a basic curiosity about the brain and its role within the central nervous system.
An important new work establishing a foundation for future developments in neural engineering The Handbook of Neural Engineering provides theoretical foundations in computational neural science and engineering and current applications in wearable and implantable neural sensors/probes. Inside, leading experts from diverse disciplinary groups representing academia, industry, and private and government organizations present peer-reviewed contributions on the brain-computer interface, nano-neural engineering, neural prostheses, imaging the brain, neural signal processing, the brain, and neurons. The Handbook of Neural Engineering covers: Neural signal and image processing–the analysis and modeling of neural activity and EEG-related activities using the nonlinear and nonstationary analysis methods, including the chaos, fractal, and time-frequency and time-scale analysis methods–and how to measure functional, physiological, and metabolic activities in the human brain using current and emerging medical imaging technologies Neuro-nanotechnology, artificial implants, and neural prosthesis–the design of multi-electrode arrays to study how the neurons of human and animals encode stimuli, the evaluation of functional changes in neural networks after stroke and spinal cord injuries, and improvements in therapeutic applications using neural prostheses Neurorobotics and neural rehabilitation engineering–the recent developments in the areas of biorobotic system, biosonar head, limb kinematics, and robot-assisted activity to improve the treatment of elderly subjects at the hospital and home, as well as the interactions of the neuron chip, neural information processing, perception and neural dynamics, learning memory and behavior, biological neural networks, and neural control
What's your worst nightmare as a doctor? Missing a life-threatening condition must be among the biggest fears for health professionals. But sometimes the clue to the diagnosis lies in just a single symptom. Alarm Bells in Medicine brings you up to speed on recognising the symptoms of serious illnesses. Internationally renowned authors list the most crucial presenting symptoms in their own specialties that should ring the alarm bells for you. They provide clear information on diagnosis and action. Organised under the relevant specialties, the information is quick and easy to find. Since patients disclose alarm symptoms in all clinical settings, this book is as relevant for consultants as it is for GPs, as useful for junior doctors as it is for medical students. Special Features of this book: Answers the express need of doctors to avoid making diagnostic errors Each chapter is written by a leading expert in the field Concise and easy to use
I used to wonder why we have so many health care managers and so few health care leaders. If you are curious about the same thing–Jo Manion explains it all in this book. –Leland R. Kaiser, president, Kaiser Consulting «Today's challenging health care environment requires leadership qualities based on fundamental interpersonal competencies. In this book Manion presents helpful insights with lots of examples for aspiring health care team members.» –James W. Varnum, president, Mary Hitchcock Memorial Hospital and Dartmouth-Hitchcock Alliance «Unique in presenting essential leadership content in a competency framework using real life examples, Jo Manion's From Management to Leadership is for anyone in or seeking a leadership role in today's chaotic, rollercoaster health care or education system.» –Carole Kenner, dean and professor, University of Oklahoma Health Sciences Center College of Nursing «For anyone who wants to be reminded about what sound leadership entails, this is the book for them. I recommend it without reservation.» –Tim Porter-O'Grady, senior partner, Tim Porter-O'Grady Associates, Inc., Atlanta, Georgia and co-author of Quantum Leadership: A Textbook of New Leadership «The communication, coaching, and motivational theories and tools Manion brings together are comprehensive and just what is needed for any leader seeking better results.» –Mary Jenkins, co-author, Abolishing Performance Appraisals and vice president of organizational learning and development, Genesys Regional Medical Center, Grand Blanc, Michigan
Presents a comprehensive picture of care, including diagnostic, therapeutic, and psychosocial aspects. The contributors cover basic science and epidemiological aspects of the public health challenge, but maintain a focus on the day to day issues encountered in dealing with affected people. Containing clear, practical advice, this text is an essential, practical resource to bridge the gap between expensive reference texts and smaller manuals. Practical Management of Haemoglobinopathies is an ideal for; Trainees and residents in haematology Hematologists in practice Healthcare professionals treating those with sickle cell disease and thalassaemia Why Buy This Book? Deals with practical problems encountered in the comprehensive care of affected individuals Each chapter written by an expert in the field Comprehensive coverage of basic science, laboratory diagnosis, psychosocial support and community care
Thoroughly revised and updated, ABC of Clinical Haematology is an essential guide and introduction to clinical haematology and to the treatment and management of common blood related disorders. The fourth edition contains new chapters that reflect the most recent developments whilst other chapters have been extensively revised to include the new tests and treatments that are now available for certain conditions such as chronic leukaemia, multiple myeloma and bleeding disorders. With contributions from leading experts in their respective fields, this text provides an ideal reference for primary care practitioners and other healthcare professionals working with patients who have blood related problems.
Covers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system This book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides an up-to-date synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract. It includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits. This new book is ideal for gastroenterologists (including trainees/fellows), clinical physiologists and educators. It is invaluable for the many scientists in academia, research institutes and industry who have been drawn to work on the gastrointestinal innervation because of its intrinsic interest, its economic importance and its involvement in unsolved health problems. It also provides a valuable resource for undergraduate and graduate teaching.
This book covers the huge advances made in clinical diagnosis enabling earlier detection, while addressing the recent progress made in treatment of hepatocellular carcinoma (HCC) to enable successful therapy. It draws on the expertise of an internationally recognized author famed for his understanding, knowledge and efforts in defining terms and diagnosis in this area. The text reviews the full range of pathological information of HCC based on the study of surgical cases and biopsy materials, along with images, to help compare findings that may be encountered by pathologists. It also makes special reference to developments in early stage HCC detection and premalignant lesions which can increase effective treatment.
An introduction to classical biostatistical methods in epidemiology Biostatistical Methods in Epidemiology provides an introduction to a wide range of methods used to analyze epidemiologic data, with a focus on nonregression techniques. The text includes an extensive discussion of measurement issues in epidemiology, especially confounding. Maximum likelihood, Mantel-Haenszel, and weighted least squares methods are presented for the analysis of closed cohort and case-control data. Kaplan-Meier and Poisson methods are described for the analysis of censored survival data. A justification for using odds ratio methods in case-control studies is provided. Standardization of rates is discussed and the construction of ordinary, multiple decrement and cause-deleted life tables is outlined. Sample size formulas are given for a range of epidemiologic study designs. The text ends with a brief overview of logistic and Cox regression. Other highlights include: Many worked examples based on actual data Discussion of exact methods Recommendations for preferred methods Extensive appendices and references Biostatistical Methods in Epidemiology provides an excellent introduction to the subject for students, while also serving as a comprehensive reference for epidemiologists and other health professionals. For more information, visit www.wiley.com/mathematics