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Список книг автора Группа авторовPeripheral Receptor Targets for Analgesia
A unique reference on peripheral pain receptor mechanisms While considerable advances have been made on pharmacotherapies for many chronic disease states, options available to treat chronic pain have remained relatively unchanged for decades. However, utilizing the receptors involved in peripheral pain transduction mechanisms offers a significant opportunity to create novel therapies for pain. A comprehensive review of peripheral pain mechanisms, Peripheral Receptor Targets for Analgesia: Novel Approaches to Pain Management provides a unique resource that brings together a body of knowledge that was previously widely dispersed. As such, it gives readers a framework for further basic and clinical studies on potential receptor targets, as well as the development of improved topical analgesics. Coverage includes: The latest discoveries by leading researchers relating to the function of various ion channels and receptors in the peripheral nervous system Novel delivery techniques An appendix listing currently available topical analgesic medications A Foreword by Professor Lars Arendt-Nielsen of the Center for Sensory-Motor Interaction (SMI) at Aalborg University An unmatched resource for improving drug therapies and making pain management more efficient, Peripheral Receptor Targets for Analgesia supplies pharmaceutical scientists, pharmacologists, neuroscientists, and graduate and upper-level undergraduate students with a comprehensive, up-to-date reference.
Molecular Pathology in Drug Discovery and Development
Covers powerful new tools for drug development Molecular pathology offers tools and techniques that can greatly enhance the drug discovery and development process, helping to make the promises of personalized medicine a reality. Molecular Pathology in Drug Discovery and Development provides an unmatched guide to this cutting-edge discipline and its applications to pharmaceutical science. With contributions from leading lights in drug discovery, drug development, and molecular pathology balanced by a consistent editorial approach, this reference offers both an overview of molecular pathology and a close look at the methods as they are applied to the process of drug discovery and development. Presented as steps in the drug development process, the coverage includes the use of molecular pathology to: Identify and validate new drug candidates Enhance transcriptional profiling to better find and validate biomarkers Assess toxicology Employ toxicogenomics to identify genes relevant to the safety of compounds Identify correct doses for different drugs Identify patients for treatment Develop molecular therapies Further the new techniques of Immunohistochemistry and Immunofluorescence With many tests and treatments already working today, drug research and development using molecular pathology has shown itself an extremely fruitful area. Molecular Pathology in Drug Discovery and Development gives practitioners an up-to-date resource on this highly active discipline and its role in furthering pharmaceutical research.
Process Scale Purification of Antibodies
Traditional column chromatography dominates current purification technology, and many of the productivity gains that have been achieved have relied on upscaling such devices. However, this comes with a cost penalty and the pharmaceutical industry has reached the point at which further upscaling becomes economically unsupportable. This book offers a broad-based reassessment of old and new purification methods, incorporating an analysis of innovative new trends in purification. The book has wide coverage of different antibody purification strategies and brings together top-tier experts to address problems in process-scale antibody purification.
Preclinical Safety Evaluation of Biopharmaceuticals
The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies. —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Evidence-Based Pediatric Infectious Diseases
Evidence-based Pediatric Infectious Diseases is a practical guide to the diagnosis and management of childhood infections in clinical practice. Renowned Clinical Professor of Pediatric Infectious Diseases, David Isaacs, and an expert consultant editor team, bring you the first book to critically look at the evidence for decision making in pediatric infections. Based around illustrative case studies, each chapter presents and analyzes current evidence on the management of different pediatric infections and provides firm treatment recommendations based on evidence of: • efficacy and safety • antibiotic resistance • cost • adverse effects • ethical considerations. Clear summaries and specific guidance allow you to assess the evidence for yourself and make rapid but informed management decisions based on the strength of evidence available. Antibiotic doses are presented clearly and simply, enabling you to select appropriate treatment at a glance. This book uses a case-based approach that focuses on the most common disease areas affecting children in industrialized countries, developing countries, travelers and refugees. It is an up-to-date, relevant and widely applicable text that carefully examines the evidence for antibiotics and other interventions whilst encouraging a conservative and responsible approach to antibiotic use. Evidence-based Pediatric Infectious Diseases is an indispensable resource for any practitioner who strives to provide the best evidence-based care for childhood infections.
A Beginner's Guide to Targeted Cancer Treatments
The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live
Diagnostic Criteria Handbook in Histopathology
This handbook is designed to help jobbing histopathologists jog their memory and get through more workload in any working day. Rapid access is facilitated by a bullet-point, tabular and diagrammatic style, as well as by handy anatomical diagrams, guidance on the ‘Cut-Up’ with emphasis on core ‘datasets’ and by a special index for frozen section advice, grading systems and scoring systems. The book provides, where useful, differential diagnosis lists and presents diagnostically helpful molecular and immunohistochemical findings. Information is kept up-to-date on a dedicated website www.pathbook.com. The Diagnostic Criteria Handbook in Histopathology is not designed to be an “exam cram” and neither will it serve as a basic text for beginners. Trainees, however, will still benefit from the sheer breadth of topics covered in this one small volume: from lab management and lab methods, to autopsy practice, cytology and all sub-specialties in surgical pathology. A chapter on exam technique and mnemonics makes the book also an essential companion for those revising for professional exams. So why clutter your precious desk space with multiple sets of heavy two-volume reference works? Give this handy Vade Mecum a place next to your microscope and see how much time you could save!
Dietary Supplements and Functional Foods
The study of nutritional supplements has become increasingly important within orthodox establishments throughout the world, and as the market for these products continues to grow, so does the need for comprehensive scientifically sound information about the products, their properties s and potent6ial health effects. Geoffrey P. Webb, in this exciting and most useful new book, not only looks at the accepted uses of dietary supplements, such as the us of fish oils in the prevention of heart disease and arthritis, but also explores the wider picture, identifying common themes and principles or particular categories of supplements. Dietary Supplements and Functional Foods provides an excellent introductory text on this fascinating subject. Written with a strategic overview approach applied to each chapter Evidence-based assessment of supplements and their contribution to the prevention and treatment of disease Detailed discussion on individual supplements and functional foods including vitamins, minerals, antioxidants and probiotics An invaluable source of reference for students and professionals in nutrition, dietetics, nutritional therapy, food science and technology and other health profession including nursing, pharmacy and pharmacology. Personnel within food and pharmaceutical companies involved with supplement and functional food development and all libraries in institutions where this subject is studies and taught will find this book an important additional to their shelves.
Improving Health through Nursing Research
Improving Health through Nursing Research is a practical guide to research and research utilisation in nursing. The book draws upon international expertise in nursing research, reflecting the worldwide demand for evidence-based practice. Part one offers a global perspective on health and nursing and addresses the development of nursing knowledge and nursing theory. Part two investigates the underlying need for nursing research, focusing on improving patient care, enhancing care delivery and developing the profession of nursing. Parts three and four provide an overview of quantitative and qualitative research methods, their selection, use and interpretation . The last three parts of the book address key issues in research ethics and provide practical guidance as to how to prepare a research proposal, undertake research, present and publish findings, and translate research into practice. Improving Health through Nursing Research; Is a practical, accessible guide for nurse researchers and nurses with an interest in research Draws upon international expertise in nursing research Explores research within the international context Explores issues at local, national and regional level Provides guidelines for developing research Includes global examples This publication in partnership with the International Council of Nurses is the essential resource for nurses seeking to understand research and research utilisation.
Nurse Prescribing in Mental Health
Nurse Prescribing in Mental health is a practical handbook for mental health nurses who are being training, have aspirations to train or who are trained in nurse prescribing. It introduces the reader to the different types of nurse prescribing and how they can be used in practice, now and in the future and reflects on the myriad of issues that are facing novice and experienced nurse prescribers. These include inter-professional relationships, team work, ethical and legal issues, governance and patient safety. The text goes on to explore the different types of medicines commonly prescribed for major disease groups and will help nurse prescribers to understand the practical application of prescribing as seen in clinical practice. Key features: Outlines the principles of prescribing and pharmacology as applied to mental health nursing Running through all of the chapters is a review of relevant nurse prescribing research and evidence that supports general prescribing practice with a direct application to clinical practice in mental health settings. Evidenced based Accessible, with case studies and scenarios in each chapter