Группа авторов
Список книг автора Группа авторовPublic Health Genomics
The Centers for Disease Control (CDC) has recognized genomics as a priority area in public health education. To help public health students and professionals achieve proficiency in the language of genetics and attain genomics competencies delineated by the CDC, this book offers an introduction to basic molecular genetics and discusses the relevance of genomics to such key public health issues as environmental health, ethnic health disparities, health policy and law, research ethics, maternal and child health, clinical preventive medicine, health behavior, health economics, and communicable disease control. Presented in a context that is easy to understand, the book serves as an accessible portal of entry into the world of public health genomics.
Human Drug Metabolism
Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body. It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine. This new text provides a concise, user-friendly introduction to drug metabolism that is ideal for undergraduates. Focusing on a conceptual understanding of the drug metabolism system, the book illustrates the basic mechanisms on how xenobiotics are detected, chemically modified and then eliminated from human systems.
Preclinical Development Handbook
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * In vitro mammalian cytogenetics tests * Phototoxicity * Carcinogenicity studies * The pharmacogenomics of personalized medicine * Bridging studies * Toxicogenomics and toxicoproteomics Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
Preclinical Development Handbook
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
High Content Screening
The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.
ABC of Adolescence
Adolescents undergo rapid physical, psychological and social developmental changes that result in management challenges, communication issues, patterns of disease and symptom presentations that are different from children or adults. This can be challenging for health professionals, who rarely have had specific training in dealing with the young people they meet in their clinical work. This ABC covers topics surrounding adolescent development, sexual behaviour and substance misuse, along with education and preventative strategies. It also features other adolescent health problems such as self-harm, eating disorders and psychosomatic presentations. This book is a valuable resource for all those who deal with adolescent patients in primary care, emergency departments, and hospital and outpatient settings.
Nutrition and Stroke
Stroke is a common and devasting event, which often results in death or major loss of independence, with immense human and financial costs. In the developed world stroke accounts for around 10 per cent of all deaths and is the most important single cause of severe disability among western people living in their own homes. Futhermore, in the next 30 years, the burden of stroke will grow substantially in most developing nations. There is now substantial evidence that dietary habits not only influence the prevalence of stroke, but also its course and outcome once it has occurred. The author, Salah Gariballa, who has many years’ experience working in this area, carefully presents and reviews this information in a user-friendly and accessible manner. The book is divided into three major sections. Section I covers nutrition and ageing and includes chapters on the challenge of stroke, ageing changes and nutrition, macro- and micronutrient intake in elderly people and the diagnosis of protein-energy undernutrition. Section II deals with nutritional factors and the risk of stroke, and includes details of the role of dietary and nutritional factors in stroke prevention, antioxidants and risk from ischaemic stroke, homocysteine and endothelial dysfunction. The final section of the book covers nutrition factors following stroke, including cerebral ischaemia, protein-energy undernutrition and the nutritional status and support of stroke and special stroke patients. A final chapter looks at probable future directions, including important recommendations. Nutrition and stroke is essential reading for nutritionists, dietitians and many other groups of health professionals, including general practitioners, gerontologists, occupational therapists and nursing staff. Personnel in pharmaceutical and food companies involved in the formulation of dietary supplements and nutraceuticals will find much of interest within the book’s covers. Those dealing with the prevention and treatment of stroke around the world should read this book, and copies should be available in libraries of universities and medical schools worldwide.
Palliative Care Resuscitation
This book provides an up to date reference for healthcare professionals working in palliative care. It provides an overview of resuscitation in palliative care, and then looks at guidelines, decision making, including patient and family in the decision making process and the law and ethics of resuscitation. Written in an easily understandable and absorbable manner, it brings to light the difficulties which may be involved in palliative care, and reinforces the importance of correct decision making and communication is in this field.
Learning Disability Nursing
Learning disability nurses play a leading role in the care and support of people with learning disabilities. Learning Disability Nursing explores the theory and practice of learning disability nursing, with an emphasis on understanding the experiences of learning disability nurses as they seek to practice effectively. It examines key issues faced by people with learning disabilities and those who support them and promotes the role of knowledgeable and reflective practitioners. * Develops a framework for learning disability nursing practice * Examines key issues for people with learning disabilities * Identifies distinctive features of learning disability nursing * Supports learning disability nurses in developing their roles and to support those with learning disabilities in exercising their rights. * Explores ethical and moral dilemmas, challenges and successes
Dual Diagnosis Nursing
The increasing number of individuals with co-existing substance misuse and psychiatric disorders presents a key challenge to mental health and addiction nurses. This practice-based text focuses on the management and intervention strategies to effectively meet the needs of this client group in both community and residential settings. Dual Diagnosis Nursing is a comprehensive text for practitioners on contemporary approaches to working with dual disorder and dual diagnosis patients. It explores both clinical and theoretical perspectives in a variety of different care and treatment settings, addressing key issues such as needs of special populations, multi-dimensional assessment, dealing with emergencies, prescribing and medication management, nursing and psychological interventions, spiritual needs, carers’ interventions and professional development.