Прочая образовательная литература
Различные книги в жанре Прочая образовательная литератураMetallotherapeutic Drugs and Metal-Based Diagnostic Agents
There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered: non-invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.
MDI and TDI: Safety, Health and the Environment
MDI and TDI are polymer building blocks used in large quantities and have a variety of applications in industry. As their use often involves large numbers of workers they are also subject to stringent health and safety regulations. This book covers all the important topics concerning MDI and TDI and provides comprehensive coverage on the health and environmental science associated with these. First comprehensive discussion of all known health and environmental information relating to MDI and TDI Draws upon the insights of academic, regulatory and industrial experts Written with the knowledge and perspective of the International Isocyanate Institute Highly illustrated volume with colour photogr aphs, spectra, tables and graphs Addressing their use throughout industry this title presents an essential source of information for occupational physicians, industrial hygiene professionals, polyurethane producers, environmental scientists, chemical analysts and regulators.
Peptide and Protein Design for Biopharmaceutical Applications
Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins Peptidomimetics Design and synthesis of cyclic peptides Carbohydrates in peptide and protein design De novo design of peptides and proteins Medical development applications An extended case study – the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.
Risk Assessment for Chemicals in Drinking Water
A comprehensive reference on state-of-the-art risk assessment methodologies for drinking water Risk Assessment for Chemicals in Drinking Water discusses the major steps and goals in risk assessments and suggests ways to improve the methodologies and accuracy, while consolidating up-to-date information on the current principles and practices in one authoritative reference. After an enlightening overview of risk assessment practices and regulatory guidelines, it: Includes descriptions of the use of variability analysis, exposure analysis, physiologically based pharmacokinetics, and modeling for both cancer and non-cancer endpoints Describes the practices of major organizations, including the U.S. EPA, Health Canada, World Health Organization, and California Office of Environmental Health Hazard Assessment Includes complete chapters on risk assessment for essential nutrients, arsenic, chloroform, and perchlorate Explains how to address susceptible sub-populations, including the elderly and infants and children, in risk assessments Covers the potential of using genomic and proteomic screens Addresses recent advances, emerging issues, and future challenges With contributions and perspectives from leading scientists, this is the definitive resource for health and environmental scientists, toxicologists, risk assessors and managers, regulators, consultants, and other professionals responsible for the safety of drinking water.
Chromatographic Methods in Clinical Chemistry and Toxicology
This book aims to fill the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts, which focus almost exclusively on clinical relevance and applications. Chromatography has a vast array of clinical applications, and though the chromatographic methods were first introduced decades ago, new applications of this technology are being used to explore previously inaccessible frontiers in clinical diagnostics and toxicological testing. An up-to-date book devoted to clinical and toxicological applications of chromatographic methods will serve as an instructional and reference text, useful to students, laboratory technicians, and researchers.
Hazardous Waste Operations and Emergency Response Manual
Field technicians and emergency response personnel are often faced with the dangers of flammable, combustible, and chemically unstable materials. Although there are numerous procedures set forth by regulatory agencies like the Occupational Safety and Health Administration (OSHA), the Environmental Protection Agency (EPA), and the National Institute for Occupational Safety and Health (NIOSH) for effectively and safely dealing with such environmental hazards, up until now there has been no single resource for training in this area. Based on the author's twenty-plus years of field experience, Hazardous Waste Operations and Emergency Response Manual is a comprehensive text that covers the complete curriculum requirements set forth by OSHA and HazWOPER. Highly accessible and broad in focus, the book is equally useful as a technical resource for training, a hands-on reference for field operations, and a textbook for environmental courses in a variety of areas. Coverage includes:Methods recommended by professional societies and regulatory agencies including the National Fire Protection Association, OSHA, EPA, and NIOSHPractical examples and assignments in each chapter to supplement the text and enhance usefulness to students.
Computational Modeling for Homogeneous and Enzymatic Catalysis
Here, the world's most active and productive computational scientists from academia and industry present established, effective and powerful tools for understanding catalysts. With its broad scope – nitrogen fixation, polymerization, C-H bond activation, oxidations, biocatalysis and much more – this book represents an extensive knowledge base for designing efficient catalysts, allowing readers to improve the performance of their own catalysts.
Single-Molecule Optical Detection, Imaging and Spectroscopy
Single Molecule Spectroscopy is one of the hottest topics in today's chemistry. It brings us close to the the most exciting vision generations of chemists have been dreaming of: To observe and examine single molecules! While most of chemistry deals with myriads of molecules, this books presents the latest developments for the detection and investigation of single entities. Written by internationally renowned authors, it is a thorough and comprehensive survey of current methods and their applications.
Electron Spin Resonance Spectroscopy of Organic Radicals
Electron spin resonance spectroscopy is the method used to determine the structure and life expectancy of a number of radicals. Written by Fabian Gerson and Walter Huber, top experts in the field of electron spin resonance spectroscopy, this book offers a compact yet readily comprehensible introduction to the modern world of ESR. Thanks to its comprehensive coverage, ranging from fundamental theory right up to the treatment of all important classes of organic radicals and triplet-state molecules that can be analyzed using ESR spectroscopy, this unique book is suitable for users in both research and industry. Instead of using complex mathematical derivations, the authors present a readily understandable approach to the field by interpreting sample spectra and classifying experimental data. In short, the ideal book for newcomers to the subject and an absolute must-have for everyone confronted with ESR spectroscopy and wanting to become acquainted with this widely-used method of analysis.
Core Concepts in Supramolecular Chemistry and Nanochemistry
Supramolecular chemistry and nanochemistry are two strongly interrelated cutting edge frontiers in research in the chemical sciences. The results of recent work in the area are now an increasing part of modern degree courses and hugely important to researchers. Core Concepts in Supramolecular Chemistry and Nanochemistry clearly outlines the fundamentals that underlie supramolecular chemistry and nanochemistry and takes an umbrella view of the whole area. This concise textbook traces the fascinating modern practice of the chemistry of the non-covalent bond from its fundamental origins through to it expression in the emergence of nanochemistry. Fusing synthetic materials and supramolecular chemistry with crystal engineering and the emerging principles of nanotechnology, the book is an ideal introduction to current chemical thought for researchers and a superb resource for students entering these exciting areas for the first time. The book builds from first principles rather than adopting a review style and includes key references to guide the reader through influential work. supplementary website featuring powerpoint slides of the figures in the book further references in each chapter builds from first principles rather than adopting a review style includes chapter on nanochemistry clear diagrams to highlight basic principles