Location-Based Services (LBS) are the delivery of data and information services where the content of those services is tailored to the current location and context of a mobile user. This is a new and fast-growing technology sector incorporating GIS, wireless technologies, positioning systems and mobile human-computer interaction. Geo-Information (GI) Engineering is the design of dependably engineered solutions to society’s use of geographical information and underpins applications such as LBS. These are brought together in this comprehensive text that takes the reader through from source data to product delivery. This book will appeal to professionals and researchers in the areas of GIS, mobile telecommunications services and LBS. It provides a comprehensive view and in-depth knowledge for academia and industry alike. It serves as essential reading and an excellent resource for final year undergraduate and postgraduate students in GIScience, Geography, Mobile Computing or Information Systems who wish to develop their understanding of LBS.
Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.
Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections – an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine and Gene Therapy: Covers new frontiers in gene therapy, animal models, vectors, gene targeting, and ethical/legal considerations Provides organ-based reviews of current studies in gene therapy for monogenetic, multifactoral or polygenic disorders, and infectious diseases Includes bold-faced terms, key concepts, summaries, and lists of helpful references by subject in each chapter Contains appendices on commercial implications and a review of the history of gene therapy This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.
Molecular and Genetic Analysis of Human Traits will address the science student human genetics market. Although incorporating two basic themes: how do we establish that a trait is hereditary, and how is the human genome organized, it will also address relevant clinical examples and key related ethical issues. New attractive features have been added, including a chapter project, and end of chapter exercises which rely on real data. Each chapter includes end of chapter exercises, and references. In-text examples and internet references are cited. Most figures will be 2 color, with some 4 color inserts.
Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss: How epidemiological cohort studies can better integrate physiological (mechanistic) measures; How best to characterise subjects’ vulnerability versus resilience by moving beyond single genetic polymorphisms; How gene hunters can benefit from recruiting samples selected for known exposures; How environmental pathogens can be used as tools for gene hunting; How to deal with potential spurious (statistical) interactions, and How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).
Data Analysis and Visualization in Genomics and Proteomics is the first book addressing integrative data analysis and visualization in this field. It addresses important techniques for the interpretation of data originating from multiple sources, encoded in different formats or protocols, and processed by multiple systems. One of the first systematic overviews of the problem of biological data integration using computational approaches This book provides scientists and students with the basis for the development and application of integrative computational methods to analyse biological data on a systemic scale Places emphasis on the processing of multiple data and knowledge resources, and the combination of different models and systems
Scattering-based numerical methods are increasingly applied to the numerical simulation of distributed time-dependent physical systems. These methods, which possess excellent stability and stability verification properties, have appeared in various guises as the transmission line matrix (TLM) method, multidimensional wave digital (MDWD) filtering and digital waveguide (DWN) methods. This text provides a unified framework for all of these techniques and addresses the question of how they are related to more standard numerical simulation techniques. Covering circuit/scattering models in electromagnetics, transmission line modelling, elastic dynamics, as well as time-varying and nonlinear systems, this book highlights the general applicability of this technique across a variety of disciplines, as well as the inter-relationships between simulation techniques and digital filter design. provides a comprehensive overview of scattering-based numerical integration methods. reviews the basics of classical electrical network theory, wave digital filters, and digital waveguide networks. discusses applications for time-varying and nonlinear systems. includes an extensive bibliography containing over 250 references. Mixing theory and application with numerical simulation results, this book will be suitable for both experts and readers with a limited background in signal processing and numerical techniques.
This IAS Special Publication #27 contains 17 of the papers presented at the IAS International Workshop on Reefs and Carbonate platforms in the Pacific and Indian oceans held in Sydney (July 1995). This is the first book to summarize the current state of knowledge about reefs and carbonate platforms in these oceans, where there is a great diversity of carbonate systems in various tectonic settings. Papers concern both processes operating in reefs and carbonate platforms and case histories (platform and oceanic reef case histories). Case histories range from the Lower Cretaceous to modern reefs and most fossil carbonate platforms concern outcomes from recent ODP legs in the Pacific. The book covers a broad spectrum of disciplines related to carbonate geology: sedimentology, geochemistry, geophysics, reef ecology and modeling. If you are a member of the International Association of Sedimentologists, for purchasing details, please see: http://www.iasnet.org/publications/details.asp?code=SP25
This book brings together a total of 48 contributions (including 5 keynote papers) which were presented at the 2nd International Workshop on the Application of X-ray CT for Geomaterials (GeoX 2006) held in Aussois, France, on 4-7 October, 2006. The contributions cover a wide range of topics, from fundamental characterization of material behavior to applications in geotechnical and geoenvironmental engineering. Recent advances of X-ray technology, hardware and software are also discussed. As such, this will be valuable reading for anyone interested in the application of X-ray CT to geomaterials from both fundamental and applied perspectives.
This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.