Прочая образовательная литература
Различные книги в жанре Прочая образовательная литератураIntegrated Strategies for Drug Discovery Using Mass Spectrometry
New strategies and techniques for today's fast-paced discovery process Today, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new analytical strategies and techniques are necessary to meet sample throughput requirements and manpower constraints. Among them, mass spectrometry has grown to be a front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometry provides a thorough review of current analytical approaches, industry practices, and strategies in drug discovery. The topics represent current industry benchmarks in specific drug discovery activities that deal with proteomics, biomarker discovery, metabonomic approaches for toxicity screening, lead identification, compound libraries, quantitative bioanalytical support, biotransformation, reactive metabolite characterization, lead optimization, pharmaceutical property profiling, sample preparation strategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry are interconnected * Discusses the uses and limitations of various types of mass spectrometry in various aspects of drug discovery * Prominently features analytical applications that require trace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques to aid in the understanding of how and why new methods are now being employed to analyze samples
Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors
Many researchers believe that GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book provides a thorough introduction to GSK-3, presents up-to-date information, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity. It’s a great reference for researchers in drug design and development.
Crystal-Liquid-Gas Phase Transitions and Thermodynamic Similarity
Professor Skripov obtained worldwide recognition with his monograph «Metastable liquids», published in English by Wiley & Sons. Based upon this work and another monograph published only in Russia, this book investigates the behavior of melting line and the properties of the coexisting crystal and liquid phase of simple substances across a wide range of pressures, including metastable states of the coexisting phases. The authors derive new relations for the thermodynamic similarity for liquid-vapour phase transition, as well as describing solid-liquid, liquid-vapor and liquid-liquid phase transitions for binary systems employing the novel methodology of thermodynamic similarity.
Noise and Signal Interference in Optical Fiber Transmission Systems
A comprehensive reference to noise and signal interference in optical fiber communications Noise and Signal Interference in Optical Fiber Transmission Systems is a compendium on specific topics within optical fiber transmission and the optimization process of the system design. It offers comprehensive treatment of noise and intersymbol interference (ISI) components affecting optical fiber communications systems, containing coverage on noise from the light source, the fiber and the receiver. The ISI is modeled with a statistical approach, leading to new useful computational methods. The author discusses the subject with the help of numerous applications and simulations of noise and signal interference theory. Key features: Complete all-in-one reference on the subject for engineers and designers of optical fiber transmission systems Discusses the physical principles behind several noise contributions encountered in the optical communications systems design, including contributions from the light source, the fiber and the receiver Covers the theory of the ISI for the binary signal, as well as noise statistics Discusses the theory and the mathematical models of the numerous noise components (such as optical noise, photodetection noise and reflection noise) Introduces the frequency description of the ISI and provides new calculation methods based on the characteristic functions Provides useful tools and examples for optimum design of optical fiber transmission networks and systems This book will serve as a comprehensive reference for researchers, R & D engineers, developers and designers working on optical transmission systems and optical communications. Advanced students in optical communications and related fields will also find this book useful.
Broadband Optical Access Networks and Fiber-to-the-Home
Broadband Optical Access and Fiber-to-the-Home (FTTH) will provide the ultimate broadband service capabilities. Compared with the currently well-deployed broadband access technologies of ADSL (Asymmetric Digital Subscriber Line) and Cable Modems, optical broadband access with Fiber-to-the-User’s home will cater for much higher speed access for new services. Broadband Optical Access Networks and Fiber-to-the-Home presents a comprehensive technical overview of key technologies and deployment strategies for optical broadband access networks and emerging new broadband services. The authors discuss network design considerations, new services, deployment trends and operational experiences, while explaining the current situation and providing insights into future broadband access technologies and services. Broadband Optical Access Networks and Fiber-to-the-Home: Offers a comprehensive, up-to-date introduction to new developments in broadband access network technologies and services. Examines the impact of research and development in photonics technologies on broadband access and FTTH. Covers ADSL, VDSL with FTTC (Fiber-to-the-Curb), Cable Modem over HFC (Hybrid-Fiber Coax) and Gigabit Ethernet. Discusses the roles of Broadband Wireless LAN and integrated FTTH/Wireless Broadband Access as well as Broadband Home Networks. Provides a global view of broadband network development, presenting different technical and system deployment approaches and strategic considerations for comparison. Gives insight into the worldwide broadband competition and the future of this technology. Broadband Optical Access Networks and Fiber-to-the-Home will be an invaluable resource for engineers in research and development, network planners, business managers, consultants as well as analysts and educators for a better understanding of the future of broadband in the field of telecommunications, data communications, and broadband multimedia service industries.
Technology of Semiactive Devices and Applications in Vibration Mitigation
Researchers have studied many methods of using active and passive control devices for absorbing vibratory energy. Active devices, while providing significant reductions in structural motion, typically require large (and often multiply-redundant) power sources, and thereby raise concerns about stability. Passive devices are fixed and cannot be modified based on information of excitation or structural response. Semiactive devices on the other hand can provide significant vibration reductions comparable to those of active devices but with substantially reduced power requirements and in a stable manner. Technology of Semiactive Devices and Applications in Vibration Mitigation presents the most up-to-date research into semiactive control systems and illustrates case studies showing their implementation and effectiveness in mitigating vibration. The material is presented in a way that people not familiar with control or structural dynamics can easily understand. Connecting structural dynamics with control, this book: Provides a history of semiactive control and a bibliographic review of the most common semiactive control strategies. Presents state-of-the-art semiactive control systems and illustrates several case studies showing their implementation and effectiveness to mitigate vibration. Illustrates applications related to noise attenuation, wind vibration damping and earthquake effects mitigation amongst others. Offers a detailed comparison between collocated and non-collocated systems. Formulates the design concepts and control algorithms in simple and readable language. Includes an appendix that contains critical considerations about semiactive devices and methods of evaluation of the original damping of a structure. Technology of Semiactive Devices and Applications in Vibration Mitigation is a must-have resource for researchers, practitioners and design engineers working in civil, automotive and mechanical engineering. In addition it is undoubtedly the key reference for all postgraduate students studying in the field.
Water and Electrolyte Metabolism in Relation to Age and Sex, Volumr 4
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Geometric Structures of Phase Space in Multi-Dimensional Chaos
This series provides the chemical physics field with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 130 in the series continues to report recent advances with significant, up-to-date chapters by internationally recognized researchers.
Preparation of Compounds Labeled with Tritium and Carbon-14
Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.
Dynamical Processes in Condensed Matter
Featuring the work of an international group of scholars, this volume covers the transport properties and Soliton models of Polyacetylene, development and application of the theory of Brownian Motion, the fading of memory during the regression of structural fluctuations, the breakdown of the Kramers Theory as a problem of correct modeling, and more.