Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis. Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include: the principles of solid phase organic synthesis electrophile and nucleophile cleavable linker units cyclative cleavage as a solid phase strategy photocleavable linker units safety-catch linker units enzyme cleavable linker units T1 and T2 –versatile triazene linker groups hydrazone linker units benzotriazole linker units phosphorus linker units sulfur linker units selenium and tellurium linker units sulfur, oxygen and selenium linker units cleaved by radical processes silicon and germanium linker units boron and stannane linker units bismuth linker units transition metal carbonyl linker units linkers releasing olefins or cycloolefins by ring-closing metathesis fluorous linker units solid-phase radiochemistry The book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis. Linker Strategies in Solid-Phase Organic Synthesis is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.
Presenting the wide range of synthetic possibilities opened by sol-gel processes in the field of organic-inorganic materials, Molecular Chemistry of Sol-Gel Derived Nanomaterials discusses the state of the art in the synthesis of the various nanomaterials. The text includes examples of applications, including photoluminescent nanocomposites, grafted nanomaterials for selective separations of ions or isotopes, for cascade syntheses, chelation of transition metals and lanthanides by lamellar structured nanomaterials, and immobilized enzymes on mesoporous nanomaterials. This indispensable text for graduate students, engineers, and scientists concludes with a look toward future developments.
Climbers, such as lianas and vines, are important constituents of tropical forests and perhaps the single most important physiognomic characteristic differentiating tropical from temperate forests, occurring on nearly 50% of forest trees in Central and South America. Despite their widespread nutritional and medicinal use, lianas remain poorly understood ecologically. Tendrillate Climbers offers comprehensive coverage of all of the tendrillate lianas of Costa Rica and most of the tendrillate lianas of Central America. This unique reference provides Excellent keys to families and separate keys to genera and species State-of-the-art nomenclature and lists of synonymy when other scientific names have been published or used informally Each species illustrated by the author’s hand-drawn line art An invaluable addition to our understanding of tropical forests, the book offers new information as well as information brought together from dispersed publications and unpublished lists and reports. In these times of habitat fragmentation and species loss, this data is a significant contribution to the biological research that is thriving in Central America, especially Costa Rica. Tendrillate Climbers fills a major gap in the botanical literature. Its high level of scholarship and comprehensive coverage will astonish the tropical botanists, forestry scientists, ecologists, biologists, and horticulturalists who will want it as a reference for their continued work on this neglected group of plants.
The TMS320C6x is Texas Instrument's next generation DSP found in over 60 percent of wireless devices from leading manufacturers such as Ericsson, Nokia, Sony, and Handspring Author has many years experience working with the TI line of TMS DSPs and his books are based on courses and seminars given at TI sponsored meetings All programs listed in the text will be available on the Wiley FTP site In addition to its wireless applications, the TMS DSP is tailored to enable a new generation of Internet media entertainment appliances
Ultra Wideband (UWB) is the hot new topic in wireless communication engineering today. High-speed communication over short distances using sub-nanosecond pulses, rather than conventional sinusoidal waves, has paved the way for cheap wireless transceivers, capturing the imagination of both academics and engineers in industry alike. Ultra Wideband Signals and Systems in Communication Engineering focuses on the basic signal processing that underlies current and future ultra wideband systems ensuring this text will be essential reading even as UWB applications mature and change or regulations regarding ultra wideband systems are modified. Provides everything you need to know about Ultra Wideband Communications in one compact volume Explains, in an easy to understand manner, the basics of UWB and its applications Covers, in detail, the generation of UWB waveforms through to the position and location of UWB signals Discusses the issues that must be solved for UWB devices to explode onto the consumer communication market Includes examples and problems in each chapter to aid understanding Features a companion website including Solutions manual, Matlab programs, Electronic versions of the figures and a sample chapter This enlightening text is a must for senior undergraduates and postgraduate students interested in studying UWB, and the emphasis on UWB development for commercial consumer communications products means that any communication engineer or manager cannot afford to be without it!
Advances in optical fibre based communications systems have played a crucial role in the development of the information highway. By offering a single mode oscillation and narrow spectral output, distributed feedback (DFB) semiconductor laser diodes offer excellent optical light sources as well as optical filters for fibre based communications and dense wavelength division multiplexing (DWDM) systems. This comprehensive text focuses on the basic working principles of DFB laser diodes and optical filters and details the development of a new technique for enhanced system performance. Considers the optical waveguiding characteristics and properties of semiconductor materials and the physics of DFB semiconductor lasers. Presents a powerful modelling technique based on the transfer matrix method which can be used to improve the design of laser diodes, optical fibres and amplifiers. Examines the effect of the various corrugation shapes on the coupling coefficients and lasing characteristics of DFB laser diodes. Technical advice to improve immunity against the spatial hole burning effect. Extensive referencing throughout and a comprehensive glossary of symbols and abbreviations. Suitable for both introductory and advanced levels This is an indispensable textbook for undergraduate and postgraduate students of electrical and electronic engineering and physics as it consolidates their knowledge in this rapidly growing field. As a technical guide for the structural design of DFB laser diodes and optical filters, the book will serve as an invaluable reference for researchers in opto-electronics, and semi conductor device physics.
As the industry environment transforms from a completely regulated setting to a broader, deregulated marketplace, new market participants must understand planning and operations of power systems to effectively participate in markets. This industry overview provides a description of utility operations and traditional planning, and then explains asset management, investment analysis, and risk management within the context of a market environment. Written to provide a broad, working knowledge of the industry, Electric Power Planning for Regulated and Deregulated Markets: Includes descriptions of generation and transmission network equipment Provides an overview of the regulatory framework, system design and systems operations for ensuring reliable delivery of power Presents system planning across different time horizons with the objective of minimizing power production costs Explains the principles and architecture of a market environment coupling operational imperatives with financial transactions Addresses approaches of various participants, including power producers, retailers, and integrated energy companies toward bidding in day ahead markets, managing risks in forward markets, portfolio development and investment analysis Provides numerous examples addressing cost minimization, price forecasting, contract valuation, portfolio risk measurement and others Examines past news events and explains what went wrong at Three Mile Island, the Northeast blackout of 2003, and the California energy crisis This is an ideal reference for professionals in the public and private power service sectors such as engineers, lawyers, systems specialists, economists, financial analysts, policy analysts, and applied mathematicians.
The thoroughly revised and updated second edition of Ultra Wideband Signals and Systems in Communication Engineering features new standards, developments and applications. It addresses not only recent developments in UWB communication systems, but also related IEEE standards such as IEEE 802.15 wireless personal area network (WPAN). Examples and problems are included in each chapter to aid understanding. Enhanced with new chapters and several sections including Standardization, advanced topics in UWB Communications and more applications, this book is essential reading for senior undergraduates and postgraduate students interested in studying UWB. The emphasis on UWB development for commercial consumer communications products means that any communication engineer or manager cannot afford to be without it! New material included in the second edition: Two new chapters covering new regulatory issues for UWB systems and new systems such as ad-hoc and sensor networks, MAC protocols and space-time coding for UWB systems IEEE proposals for channel models and their specifications Interference and coexistence of UWB with other systems UWB antennas and arrays, and new types of antennas for UWB systems such as printed bow-tie antennas Coverage of new companies working on UWB such as Artimi and UBISense UWB potential for use in medicine, including cardiology, respiratory medicine, obstetrics and gynaecology, emergency room and acute care, assistance for disabled people, and throat and vocals Companion website features a solutions manual, Matlab programs and electronic versions of all figures.
T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents up-to-the-minute data on the role of T cells in autoimmune diseases.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.