Pathology of Genetically Engineered and Other Mutant Mice. Группа авторов

11.9 Mammary Intraepithelial Neoplasia (MIN). This figure illustrates...Figure 11.10 Case study. (a) A histological image of an HE stained Stat1 KO ...

      12 Chapter 12Figure 12.1 Nasal hyalinosis. Eosinophilic protein inclusions and a few intr...Figure 12.2 Massive nasal poxvirus infection of the nasal cavity. [10]. Intr...Figure 12.3 Whole lung infused with formalin. Left, right, and accessory lob...Figure 12.4 iBALT in mouse lung. Perivascular and bronchiolar lymphoid nodul...Figure 12.5 Perfused lung embedded with heart. Note lobes shown are uniforml...Figure 12.6 Individual lung lobes for embedding. The fixed lung lobes were i...Figure 12.7 SCGB1A1 in bronchiolar club cells. The club cell antigen is pres...Figure 12.8 Gross necropsy findings of pulmonary hyalinosis (crystalline pne...Figure 12.9 Whole lung section with crystalline pneumonia. The lesions are d...Figure 12.10 Early lung lesions of an Ncf1 ^m1J homozygous mutant mouse. Th...Figure 12.11 CHIL3 in alveolar macrophages. Early lesions of hyalinosis in a...Figure 12.12 Alveolar macrophages in a Lat ^tm1Les homozygous mutant mouse....Figure 12.13 Alveolar macrophages in an Ncf1 ^m1J homozygous mutant mouse. ...Figure 12.14 Alveolar macrophages in an Ncf1 ^m1J homozygous mutant mouse. ...Figure 12.15 Electron micrograph of the CHIL3 crystals. Note the thin needle...Figure 12.16 Foreign material in bronchiole. After intranasal administration...Figure 12.17 Centrilobular distribution of induced inflammatory lesions. Nin...Figure 12.18 Lobular distribution of induced lesions. Fifteen days postnasal...Figure 12.19 Diffuse distribution of induced lesions. Five days postnasal in...Figure 12.20 Viral antigen in bronchiolar epithelium. SARS CoV in bronchiola...Figure 12.21 Viral antigen in bronchiolar club cells and alveolar cells. Day...Figure 12.22 H5N1 influenza viral antigen in lung. Day 2 after infection in ...Figure 12.23 Acute viral lesions in a bronchiole. There is necrosis of bronc...Figure 12.24 Bronchiolar hyperplasia. Hyperplastic club cells after naturall...Figure 12.25 Viral antigen in alveolar cells. Mice infected with pneumonia v...Figure 12.26 Interstitial pneumonia. Alveolar walls are thickened, and infla...Figure 12.27 Alveolar bronchiolization. Naturally‐occurring chronic Sendai v...Figure 12.28 Migration of leukocytes from arteriole into lung. Leukocytes ar...Figure 12.29 Vasculitis. Migration (arrows) of CD3⁺ lymphocytes through wall...Figure 12.30 Pyogranuloma in the lung. A large lesion with central necrosis ...Figure 12.31 SARS CoV antigen in macrophages in a pyogranuloma as in Figure ...Figure 12.32 Ectopic mineralization. Foci of mineralization can be found sca...Figure 12.33 Club cell mucous metaplasia. Note the variable mucus in each cl...Figure 12.34 PAS stain of club cell mucous metaplasia. OVA model with peribr...Figure 12.35 Fibrosis, alveolar. Masson's trichrome stain shows abundant col...Figure 12.36 Hyperplasia, alveolar. Alveolar Type II cell (AT2) hyperplasia ...Figure 12.37 Hyperplasia, alveolar Type II cells (AT2). TTF1 antigen (NKX2‐1...Figure 12.38 Adenoma, alveolar Type II cell (AT2). The tumor cells are unifo...Figure 12.39 Adenocarcinoma (right side) in an adenoma. Note the papillary l...Figure 12.40 Cell proliferation in the adenocarcinoma developing in an adeno...Figure 12.41 Alveolar Type II cell (AT2) antigen (SFTPD). The antigen can be...Figure 12.42 Papillary bronchiolar hyperplasia. Multiple lesions in the bron...Figure 12.43 SCGB1A1 antigen in papillary hyperplasia. Note the adenoma and ...Figure 12.44 SCGB1A1 antigen in bronchioles. Note lack of labeling in adenom...Figure 12.45 Adenocarcinoma. Solid and papillary patterns can be seen.Figure 12.46 Squamous metaplasia. Squamous lesions in bronchiole and alveoli...Figure 12.47 Neuroendocrine carcinoma. Small cell carcinoma in a mutant mous...Figure 12.48 Metastatic liver tumors in lung. Note many tumor nodules of var...

      13 Chapter 13Figure 13.1 Trimming and embedding protocol for mouse stomach. The stomach i...Figure 13.2 Example of 6 normal stomach sections from one mouse on one slideFigure 13.3 Stomach from mouse with diffuse and focal gastric proliferative ...Figure 13.4 Mouse stomachs with several glandular stomach hyperplastic plaqu...Figure 13.5 Hyalinosis in glandular stomach. There are intracellular and ext...Figure 13.6 Gastric crystals. The CHIL3‐containing gastric crystals of vario...Figure 13.7 Gastric yeast. Many yeast, Kazachstania pintolopesii, are seen o...Figure 13.8 Glandular stomach. Chronic gastritis with diffuse epithelial hyp...Figure 13.9 Glandular stomach. Mucus metaplasia, diffuse in hyperplastic gas...Figure 13.10 Glandular stomach. Focal gastric dysplasia in chronic gastritis...Figure 13.11 Glandular stomach antrum. Diffuse gastric hyperplasia and pylor...Figure 13.12 Glandular stomach. Single large gastric adenoma at the transiti...Figure 13.13 Gastric adenocarcinoma invading through the layers of the stoma...Figure 13.14 Forestomach. Squamous cell carcinoma.Figure 13.15 Pylorus. Atypical adenomatous hyperplasia with epithelial herni...Figure 13.16 Gastric herniation. Arising as hyperplastic glands grow through...Figure 13.17 Small intestinal gut roll. Multiple lesions (dysplasias, microa...Figure 13.18 Large intestinal gut roll. It is closed (a) and opened (b) with...Figure 13.19 Colitis trim protocol. The first two sections of descending col...Figure 13.20 Colon. Gross appearance of colon adenomas (polyps), azoxymethan...Figure 13.21 Colon. Focus of dysplasia. One crypt is involved.Figure 13.22 Small intestine. Focal dysplasia, multiple crypts. Hyperchromas...Figure 13.23 Colon. Multifocal hyperplasia with dysplasia in a regenerative ...Figure 13.24 Focus of colonic regenerative hyperplasia in induced colitis mo...Figure 13.25 Small intestine. Microadenoma, with high‐grade dysplasia.Figure 13.26 Small intestine. CTNNB1 in focal dysplasia. Nuclear staining in...Figure 13.27 Small intestine. CTNNB1 in dysplasia. Note the nuclear and cyto...Figure 13.28 Small intestine, adenoma, sessile. No invasion is seen.Figure 13.29 Comparative histogenesis of colon adenocarcinoma in humans (top...Figure 13.32 Adenocarcinoma, small intestine, mouse. Invasion to the serosa....Figure 13.33 Colon. Adenocarcinoma, mucinous, with cystic mucinous areas in ...Figure 13.34 Colon. High magnification of 13.33 showing the cystic areas dev...Figure 13.35 Colon. Diffuse invasive adenocarcinoma showing muscle and lymph...Figure 13.36 Cecum, gastrointestinal stromal tumor (GIST) in a mutant mouse....Figure 13.37 Colon hamartoma in a Cdx2 ^tm1Mmt mouse. The cystic proliferat...

      14 Chapter 14Figure 14.1 Longitudinal section of HE stained heart from a NZW/LacJ mouse d...Figure 14.2 Cross section of Masson's trichrome stained normal large elastic...Figure 14.3 Normal mouse medium pulmonary vein with abundant striated cardia...Figure 14.4 Cross section of Masson's trichrome stained normal medium muscul...Figure 14.5 Transverse sections of the heart can be performed at mid papilla...Figure 14.6 Longitudinal section of HE stained normal heart showing the LVFW...Figure 14.7 Atherosclerosis lesion stained with Oil Red O for image quantifi...Figure 14.8 Heart, aorta, and branches from a normal mouse. The mouse was pe...Figure 14.9 Cross section of a Movat's pentachrome stained medium muscular a...Figure 14.10 Wheat Germ Agglutinin (WGA) binds to glycoproteins of the cell ...Figure 14.11 Normal mice may have an os cordis within the annulus fibrosus s...Figure 14.12 Polyarteritis Nodosa is a common background lesion in a number ...Figure 14.13 Gross (a) and histologic (b) images of epicardial mineralizatio...Figure 14.14 Gross image of a large pale thrombus in the atrium (a) creating...Figure 14.15 Longitudinal section of Masson's trichrome stained heart. The a...Figure 14.16 Oblique cross section of HE stained aortic valve showing numero...Figure 14.17 Abundant fibrin with enmeshed degenerate neutrophils and large ...Figure 14.18 Spontaneous hemangiosarcoma characterized by poorly formed vasc...Figure 14.19 Masson's trichrome stain demonstrating abundant replacement fib...Figure 14.20 HE stain of