Pathology of Genetically Engineered and Other Mutant Mice. Группа авторов

a mouse with arteriolosclerosis with a narrowed l...Figure 14.22 Florid pulmonary hypertension lesions in a transgenic mouse wit...Figure 14.23 In this HE stain, the aortic root has a mononuclear infiltrate ...Figure 14.24 HE staining of the aortic root from an B6.129P2‐Apoe^tm1Unc/J mo...

      15 Chapter 15Figure 15.1 Role of hepatoblasts in liver. Differentiation of hepatoblasts i...Figure 15.2 Trimming the liver. How to obtain mouse liver sections for histo...Figure 15.3 HCC in mouse liver. Gross liver tumors in a two‐year‐old mouse. ...Figure 15.4 HCC in mouse liver. Liver masses in a Liver‐Onc3/HBsAg mouse. Mu...Figure 15.5 Liver microenvironment. The liver microenvironment is composed o...Figure 15.6 Connexin 32 (GJB1) immunostaining. Connexin 32 (GJB1) in the liv...Figure 15.7 Fibrosis/cirrhosis in mouse livers. Photomicrograph of the liver...Figure 15.8 Fatty change in mouse liver. Fatty change, centrilobular, mouse ...Figure 15.12 Fibrosis in mouse liver. Hepatic periportal fibrosis in a mouse...Figure 15.13 On the origin of liver cancer. Hepatocyte and Hepatic Progenito...Figure 15.14 Hepatocellular adenoma, basophilic with clear cells.Figure 15.15 Large hepatocellular adenoma with clear cell and lipid areas.Figure 15.16 Mouse liver parenchymal compression by adenoma. Edge of hepatoc...Figure 15.17 Mouse liver – trabecular hepatocellular carcinoma developing in...Figure 15.18 Mouse lung with metastases of hepatocellular carcinoma.Figure 15.19 Metastases of hepatocellular carcinoma in lung. Basophilic area...Figure 15.20 Hyaline droplets in pancreatic duct. Hyalinosis in an interlobu...Figure 15.21 Human PDAC. Human PDAC showing ductal morphological and extensi...Figure 15.22 Human PDAC – adenosquamous variant. Adenosquamous variant...Figure 15.23 Human and mouse PanIN. From left to right: PanIN1, 2 (both now ...Figure 15.24 Pancreatic remodeling. Remodeling of the acinar compartment of ...Figure 15.26 Acinar‐to‐ductal and mucinous metaplasia. Acinar‐to...Figure 15.27 Atypical flat lesion. Atypical flat lesion (AFL) (center) adjac...Figure 15.28 Ductular‐insular complex. Ductular‐insular complex (right...Figure 15.29 Mouse PDAC G2. Moderately differentiated PDAC in a Tg(Pdx1‐...Figure 15.30 Mouse PDAC G3. Poorly differentiated PDAC in a Tg(Pdx1‐cr...Figure 15.31 Sarcomatoid mouse PDAC. Sarcomatoid PDAC in a Tg(Pdx1‐cre...Figure 15.32 E‐cadherin expression in sarcomatoid mouse PDAC. Retained...Figure 15.33 Intravascular tumor cells. Tumor cell invasion into an intrapan...Figure 15.34 Pulmonary metastasis. Pulmonary metastasis of a PDAC in a Tg(Pd...Figure 15.35 Primary lung adenoma. Primary lung adenoma in a Tg(Pdx1‐c...

      16 Chapter 16Figure 16.1 Mouse skeletal muscle. (a) Transverse section of spinal column s...Figure 16.2 Mouse spinal cord. (a) Artifactual vacuolization of neurons and ...Figure 16.3 Mouse quadriceps muscle. (a) Transverse section of wild‐type qua...Figure 16.4 Mouse skeletal muscle – neurogenic myopathy. (a) Showing contras...Figure 16.5 Mouse spinal cord – lower motor neurons. (a) “Ghost” motor neuro...Figure 16.6 Mouse spinal cord. (a) Luxol fast blue stain highlight reduced m...Figure 16.7 Mouse sciatic nerve. (a–c) Transverse sections show normal sciat...Figure 16.8 Mouse femoral nerve. (a, b) Longitudinal sections show normal ap...Figure 16.9 Mouse skeletal muscle – neuromuscular junction (NMJ). (a) ...Figure 16.10 Mouse skeletal muscle – muscle spindle. (a) Normal muscle...Figure 16.11 Mouse skeletal muscle – interosseous membrane and Pacinian corp...Figure 16.12 Mouse skeletal muscle – myogenic myopathy. (a) Internaliz...Figure 16.13 Mouse skeletal muscle – regeneration. (a) Regenerating fi...Figure 16.14 Mouse skeletal muscle – old male mice. (a) Prominent cont...Figure 16.15 Mouse skeletal muscle. (a) Centralized nuclei and ring fibers. ...Figure 16.16 Mouse skeletal muscle – autophagy myopathies. (a) Interna...

      17 Chapter 17Figure 17.1 Pituitary gland in situ observed within the sella turcica upon r...Figure 17.2 Photomicrograph of the pituitary gland in situ overlying the bas...Figure 17.3 The pituitary gland is enlarged and red due to the presence of a...Figure 17.4 A focal adenoma (left) within the pars distalis is associated wi...Figure 17.5 Centrally, an adenoma of the pars intermedia is compressing the ...Figure 17.6 Bilaterally, the lobes of the thyroid gland are attached to the ...Figure 17.7 Diffuse bilateral follicular hyperplasia (goiter) secondary to i...Figure 17.8 Thyroid follicular hyperplasia and dysplasia characterized by co...Figure 17.9 Marked lymphocytic infiltrates are disrupting normal thyroid fol...Figure 17.10 Bilateral follicular thyroid carcinomas.Figure 17.11 Follicular thyroid carcinoma.Figure 17.12 Intravascular rafts of follicular thyroid carcinoma cells.Figure 17.13 Pulmonary metastasis of follicular thyroid carcinoma.Figure 17.14 Thyroid C cell adenoma.Figure 17.15 Chief cells within the parathyroid gland are widely separated b...Figure 17.16 Parathyroid chief cell adenoma.Figure 17.17 Bilateral regression of the adrenocortical X‐zone as evidenced ...Figure 17.18 Large macrophages containing yellowish‐brown pigment are associ...Figure 17.19 Subcapsular proliferation of type A spindle cells (right) and a...Figure 17.20 Focal pheochromocytoma at the cortical‐medullary junction that ...Figure 17.21 Aldehyde fuchsin histochemical staining of insulin within ß cel...Figure 17.22 Mouse islets of variable sizes can be organized in close proxim...Figure 17.23 Numerous hyperplastic and neoplastic islets distributed through...Figure 17.25 Hyperplastic and neoplastic islets in the pancreas of a Men1 he...Figure 17.26 The pineal gland is located dorsally in a coronal section of th...

      18 Chapter 18Figure 18.1 Normal kidney. Longitudinal section shows cortex, medulla, papil...Figure 18.2 Normal kidney. Bowman capsule with flat or cuboidal epithelium i...Figure 18.3 Normal glomerulus. Vimentin (VIM) IHC. Note foot processes of po...Figure 18.4 Normal glomerulus. Kinase insert domain protein receptor (KDR, f...Figure 18.5 Focal segmental glomerular sclerosis (FSGS), SAND model, 36 expe...Figure 18.6 Focal segmental glomerular sclerosis (FSGS), SAND model, 36 week...Figure 18.7 Proliferative glomerulonephritis. Increased cellularity of glome...Figure 18.8 Membranous glomerulonephritis. Thickened glomerular capillary ba...Figure 18.9 Membranoproliferative glomerulonephritis. Increased cellularity ...Figure 18.10 Sclerotic glomerulus. PAS stain shows positive material in mesa...Figure 18.11 Amyloid. Hyaline material throughout the glomerulus, adhesions ...Figure 18.12 Amyloid. Congo Red stain reveals amyloid. Aged C57BL/6J mouse....Figure 18.13 Collagenopathy. Note abundant eosinophilic material in glomerul...Figure 18.14 Collagenopathy. Note abundant collagen (blue) in glomeruli. Mas...Figure 18.15 Immune‐mediated glomerulonephritis. Human kappa light cha...Figure 18.16 Fibronectin glomerulopathy. Increased focal and diffuse mesangi...Figure 18.17 Tumor lysis syndrome. Blue material is DNA from a necrotic T‐ce...Figure 18.18 Tumor metastases within glomerulus. Metastatic CD3⁺ (CD3E) lymp...Figure 18.19 Tumor metastases within glomerulus. Histiocytic sarcoma cells w...Figure 18.20 Lupus glomerulonephritis. IgG (green) and C3 (red) fluorescence...Figure 18.21 Polycystic kidney. Note numerous dilated and cystic tubules occ...Figure 18.22 Glycogen storage disease. There is abundant glycogen in tubular...Figure 18.23 Chapparvovirus (MKPV, mouse kidney parvovirus) infection. Many ...Figure 18.24 Streptozocin‐induced clear intranuclear tubule cell inclusions...Figure 18.25 Preneoplastic renal tubule cell atypical hyperplasia. A single ...Figure 18.27 Renal papillary tubular adenoma. There is compression of adjace...Figure 18.28 Solid renal tubular cell adenocarcinoma. Necrosis is seen. Chem...Figure 18.29 Renal clear cell carcinoma. Glycogen‐like clear cytoplasm. Chem...Figure 18.30 Bladder fixation and trimming protocol. Inflate bladder with 50...Figure 18.31 Bladder diffuse and nodular hyperplasia. Note diffuse and nodul...Figure 18.32 Large and small bladder papillomas. The adjacent epithelium is ...Figure 18.33 Bladder transitional