Pathology of Genetically Engineered and Other Mutant Mice. Группа авторов

19Figure 19.1 Mouse reproductive tract. (a) Mouse reproductive tract in situ. ...Figure 19.2 Protocol for longitudinal and cross sections of uterine tissue. ...Figure 19.3 Cystic and hemorrhagic ovaries from Esr1^−/−‐Rosa26...Figure 19.4 Hypoplastic uterus from an Esr1^tm3.1Ksk/Esr1^tm3.1Ksk mouse. (a) ...Figure 19.5 Mouse high‐grade serous carcinoma arising from the ovarian surfa...Figure 19.6 Mouse high‐grade serous carcinoma arising from the tubal epithel...Figure 19.7 Mouse serous endometrial carcinoma. (a) Early atypical lesions 6...Figure 19.8 Spontaneous granulosa cell tumor in an aged FVB/NJ mouse (a and ...Figure 19.9 Spontaneous ovarian cysts in an aged C57L/J mouse (a and b). Cys...Figure 19.10 Spontaneous luteoma in the ovary of an aged 129S1/SvlmJ mouse (...

      20 Chapter 20Figure 20.1 Mouse male reproductive system. Seminal vesicles (SV), preputial...Figure 20.2 Mouse prostate and associated accessory sex glands en bloc. Semi...Figure 20.3 The mouse preputial glands are composed of acini (A) and large, ...Figure 20.4 The Bulbourethral glands (Cowper’s glands) are multilobular glan...Figure 20.5 Ampullary glands are lined by a cuboidal epithelium with charact...Figure 20.6 The Seminal vesicles are composed of tall columnar epithelium (E...Figure 20.7 Benign polyp of the seminal vesicles in the TRAMP (Tg(TRAMP)8247...Figure 20.8 Gross prostate lobes and Seminal vesicles. (a) Ventral view, (b)...Figure 20.9 The four mouse prostate lobes are histologically distinct. (a) C...Figure 20.10 Classification of lesions of the prostate in genetically engine...Figure 20.11 TRAMP (Tg(TRAMP)8247Ng) mouse model with neuroendocrine carcino...Figure 20.12 Prostatic adenocarcinoma from a mouse with conditional prostate...Figure 20.13 Adenocarcinoma from an overexpressing MYC (FVB‐Tg(ARR2/Pbsn‐MYC...Figure 20.14 Neuroendocrine carcinoma metastasis to the liver from TRAMP mod...Figure 20.15 Testis. (a) Normal seminiferous tubules (arrowheads) separated ...Figure 20.16 Testis. Multinucleate germ cells (symplasts). Symplasts (arrows...Figure 20.17 Testis. Straight seminiferous tubules (tubuli recti) are lined ...Figure 20.18 Epididymis. (A) The head of the epididymis has small lumen line...Figure 20.19 Epididymis, Epithelium with focal karyomegaly. An atypical enla...Figure 20.20 Testis. (a) Tubular necrosis. (b) A higher magnification of ins...Figure 20.21 Epididymis, tail. Dilation, sperm stasis, and granuloma. (a) Se...Figure 20.22 (a) Epididymis‐segmental dilation (arrows) with luminal aggrega...Figure 20.23 Epididymis, body. Epithelial vacuolation. This finding was not ...Figure 20.24 Testis. Diffuse tubular atrophy/hypoplasia. (a) Complete germ c...Figure 20.25 Testis. Multifocal tubular atrophy/hypoplasia, multifocal. (a) ...Figure 20.26 Testis. Failure of meiosis. Seminiferous tubules show spermatoc...Figure 20.27 Testis, Defects in spermiogenesis and spermiation. (a) Defect i...Figure 20.28 Testis. Degeneration of elongated spermatids. Large structures ...Figure 20.29 Testis. Tubular degeneration/atrophy with multinucleate germ ce...Figure 20.30 Testis. Germ cell dissociation. (a) Germ cells are dissociated ...Figure 20.31 Mouse testis. Teratoma. (a) Differentiation into epithelial, me...

      21 Chapter 21Figure 21.1 Dorsal view of brain.Figure 21.2 Ventral view of brain.Figure 21.3 Coronal (cross) section of brain at the level of the thalamus, w...Figure 21.4 Coronal (cross) section of brain at the level of the midbrain, w...Figure 21.5 Artifactual vacuolation of the white matter of the cerebellum fo...Figure 21.6 Artifactual spaces surrounding the vessels following intravascul...Figure 21.7 Parasagittal (lateral of midline) section of brain. Nissl stain....Figure 21.8 Sagittal section of spine, showing the orientation of the spinal...Figure 21.9 Cross section of the spinal cord in situ with nerves and ganglia...Figure 21.10 Cross section of spinal cord in situ in an aged C57BL/6 mouse w...Figure 21.11 Dark neuron artifact in mouse cerebrum. HE.Figure 21.12 Touch artifact at the surface of the mouse cerebrum due to hand...Figure 21.13 Hypereosinophilic, dead neurons in the cerebrum of an FVB mouse...Figure 21.14 Artifactual clear space (halos) surrounding oligodendrocytes in...Figure 21.15 Artifactual clear space (perivascular clefts) surrounding blood...Figure 21.16 Artifactual clear space and separation of the dentate gyrus of ...Figure 21.17 Histologic appearance of the normal corpus callosum in a BALB/c...Figure 21.19 Dermoid cyst in the spinal cord of a B6SJL‐Tg(SOD1*G93A)1Gur/J ...Figure 21.20 Encephalitis and abscesses in an immunosuppressed Myd88tm1Aki m...Figure 21.21 Eosinophilic intracytoplasmic neuronal inclusions in the thalam...Figure 21.22 Neuroaxonal dystrophy in the medulla oblongata (gracilis nucleu...Figure 21.23 Neoplastic lymphocytes (lymphoma) expanding the meninges of an ...Figure 21.24 Neuronal loss with astrogliosis in a mouse with a conditional n...Figure 21.25 Ubiquitin positive plaques in the cortex of a seven‐month‐old f...Figure 21.26 Amyloid beta positive plaques in the cortex of a seven‐month‐ol...Figure 21.27 Amyloid plaques and microgliosis in the cortex of a six‐month‐o...Figure 21.28 Tauopathy and neurofibrillary tangles in the medulla oblongata ...Figure 21.29 Constitutive tyrosine hydroxylase expression in the substantia ...Figure 21.30 Neurodegenerative changes with Lewy body‐like inclusions in the...Figure 21.31 Inflammation and demyelination in the spinal cord of a mouse mo...Figure 21.32 Neurons with accumulated intracytoplasmic vacuolated material i...Figure 21.33 Medulloblastoma at the level of the medulla and cerebellum. Ins...

      22 Chapter 22Figure 22.1 Age‐matched E13.5 littermates, in which the mouse on the right h...Figure 22.2 Histologic section of affected E13.5 embryo in Figure 22.1, whic...Figure 22.3 Phthisis bulbi resulting from a chronic, severe uveitis in a C57...Figure 22.4 Phthisis bulbi resulting from the compression of the globe by an...Figure 22.5 Corneal opacity in a C57BL/6 mouse arising from keratoconjunctiv...Figure 22.6 Healing corneal ulceration in a C57BL/6 mouse. Superficially the...Figure 22.7 Ocular melanosis in the eye of a C57BL/6 mouse with no notable f...Figure 22.8 Pigment‐associated glaucoma in an aged C57BL/6 mouse. There is a...Figure 22.9 Retinal degeneration in a Swiss Webster outbred model from the R...Figure 22.10 Retinal dysplasia. There is disorderly differentiation, blendin...Figure 22.11 Coronal sections of mouse head. (a) Low magnification view show...Figure 22.12 Failure of mesenchymal condensation and development of superior...Figure 22.13 Otitis media in mouse with a lysosomal storage disease. (a) Mid...Figure 22.14 Lesions of the organ of Corti. Arrows indicate outer hair cells...Figure 22.15 Deafness phenotype in mouse lacking vesicular glutamate transpo...Figure 22.16 Decreased to absent otoconia over the macula (M). (a) Normal ap...

      23 Chapter 23Figure 23.1 Mouse bone. (a) Enzyme histochemistry showing TRAP‐positive oste...Figure 23.2 Mouse sternebrae. (a) Wild‐type C57BL/6 mouse showing typical tr...Figure 23.3 Mouse bone – renal osteodystrophy. Increased numbers of os...Figure 23.4 Mouse turbinate. (a) Proliferating cells in bones of ascorbate‐d...Figure 23.5 Mouse femur. Healing fracture in ascorbate‐deficient mouse.Figure 23.6 Mouse kidney (a) and lung (b). Ectopic mineralization.Figure 23.7 Mouse sternum. (a) Cortical and trabecular bone are disorganized...Figure 23.8 Mouse femorotibial joint. (a) Wild‐type bone stained with Alcian...Figure 23.9 Mouse incisor tooth – Amelogenesis imperfecta. (a) Disorga...Figure 23.10 Mouse molar teeth – Dentinogenesis imperfecta. (a) Parall...Figure 23.11 Aged mouse incisor. Deep clefting of enamel layer, intrapulpal ...

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