Handbook of Clinical Gender Medicine. Группа авторов

support specifically because it is a comprehensive tool effective at detecting and predicting numerous health outcomes. In this chapter, we have explored the diverse antecedents and consequences of increased AL that are influenced by sex and gender throughout the life cycle. Such interactions force us to reconsider how dichotomous and dimensional variables coexist to affect a wide spectrum of behaviors, cognitions, and lifelong propensities of health and well-being. In an effort to promote person-centered approaches, we have outlined a simple formula to calculate a clinical AL index that could be effectively combined with other interdisciplinary methods. While treatment options are needed, an AL index can guide medical professionals towards preventive strategies that respect vast inter-and intraindividual differences.

      References

1 McEwen BS, Seeman T: Protective and damaging effects of mediators of stress: elaborating and testing the concepts of allostasis and allostatic load. Ann NY Acad Sci 1999;896:30–47.

2 McEwen BS, Stellar E: Stress and the individual: mechanisms leading to disease. Arch Intern Med 1993;153:2093–2101.

3 Dickerson SS, Kemeny ME: Acute stressors and cortisol reactivity: a meta-analytic review. Psychosom Med 2002;54:105–123.

4 Lupien SJ, Ouelle-Morin I, Hupback A, Walker D, Tu MT, Buss C, Pruessner JC, McEwen BS: Beyond the stress concept: allostatic load - a developmental biological and cognitive perspective; in Cicchetti D (ed): Handbook Series on Developmental Psychopathology. New Jersey, Wiley, 2004, pp 784–809.

5 Sterling P, Eyer J: Allostatis: a new paragidm to explain arousal pathology; in Fisher S, Reason J (eds): Handbook of Life Stress, Cognition and Health. New York, Wiley, 1998, pp 629–649.

6 Lupien SJ, McEwen BS, Gunnar MR, Heim C: Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 2009;10:434–445.

7 McEwen BS: Protective and damaging effects of stress mediators. N Engl J Med 1998;338:171–179.

8 Juster RP, McEwen BS, Lupien SJ: Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev 2010;35:2–16.

9 Seeman TE, Singer BH, Rowe JW, Horwitz RI, McEwen BS: Price of adaptation: allostatic load and its health consequences - MacArthur studies of successful aging. Arch Intern Med 1997;157:2259–2268.

10 Juster RP, Bizik G, Picard M, Arsenault-Lapierre G, Sindi S, Trepanier L, Marin MF, Wan N, Sekorovic Z, Lord C, Fiocco AJ, Plusquellec P, McEwen BS, Lupien SJ: A transdisciplinary perspective of chronic stress in relation to psychopathology throughout lifespan development. Dev Psychopathol 2011;725–776.

11 Juster RP, Sindi S, Marin MF, Perna A, Hashemi A, Pruessner JC, Lupien SJ: A clinical allostatic load index is associated with burnout symptoms and hypocortisolemic profiles in healthy workers. Psychoneuroendocrinology 2010;36:797–805.

12 Gruenewald TL, Seeman TE, Ryff CD, Karlamangla AS, Singer BH: Combinations of biomarkers predictive of later life mortality. Proc Natl Acad Sci USA 2006;103:14158–14163.

13 Seeman TE, Singer BH, Ryff CD, Dienberg Love G, Levy-Storms L: Social relationships, gender, and allostatic load across two age cohorts. Psychosom Med 2002;64:395–406.

14 Seeman TE, Gruenewald T, Karlamangla A, Sidney S, Liu K, McEwen BS, Schwartz J: Modeling multisystem biological risk in young adults: The Coronary Artery Risk Development in Young Adults Study. Am J Hum Biol 2010;22:463–472.

15 Stroud LR, Salovey P, Epel ES: Sex differences in stress responses: social rejection versus achievement stress. Biol Psychiatry 2002;52:318–327.

16 Taylor SE, Klein LC, Lewis BP, Gruenewald TL, Gurung RA, Updegraff JA: Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight. Psychol Rev 2000;107:411–429.

17 Karlamangla AS, Singer BH, Seeman TE: Reduction in allostatic load in older adults is associated with lower all-cause mortality risk: MacArthur studies of successful aging. Psychosom Med 2006;68:500–507.

18 Crimmins EM, Johnston M, Hayward M, Seeman TS: Age differences in allostatic load: an index of physiological dysregulation. Exp Gerontol 2003;38:731–734.

19 Crimmins EM, Kim JK, Seeman TE: Poverty and biological risk: the earlier ‘aging’ of the poor. J Gerontol A Biol Sci Med Sci 2009;64:286–292.

20 McEwen BS: Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 2007;87:873–904.

      Sonia J. Lupien, PhD

      Center for Studies on Human Stress, Fernand-Seguin Research Center

      Louis-H. Lafontaine Hospital

      7401 Hochelaga Street

      Montreal, QC, H1N 3M5 (Canada)

       Tel. [phone], E-Mail [email protected]

      Central Nervous System and Clinical Applications

      Schenck-Gustafsson K, DeCola PR, Pfaff DW, Pisetsky DS (eds): Handbook of Clinical Gender Medicine.

       Basel, Karger, 2012, pp 82–91

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Autism

Rebecca Knickmeyer^a · Simon Baron-Cohen^b

^aDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA; ^bAutism Research Center, Department of Psychiatry, University of Cambridge, Cambridge, UK

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      Abstract

      One of the most striking features of autism spectrum conditions (ASC) is that they occur significantly more often in males than in females. Despite this dramatic