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As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Multivalency. Concepts, Research and Applications
Connects fundamental knowledge of multivalent interactions with current practice and state-of-the-art applications Multivalency is a widespread phenomenon, with applications spanning supramolecular chemistry, materials chemistry, pharmaceutical chemistry and biochemistry. This advanced textbook provides students and junior scientists with an excellent introduction to the fundamentals of multivalent interactions, whilst expanding the knowledge of experienced researchers in the field. Multivalency: Concepts, Research & Applications is divided into three parts. Part one provides background knowledge on various aspects of multivalency and cooperativity and presents practical methods for their study. Fundamental aspects such as thermodynamics, kinetics and the principle of effective molarity are described, and characterisation methods, experimental methodologies and data treatment methods are also discussed. Parts two and three provide an overview of current systems in which multivalency plays an important role in chemistry and biology, with a focus on the design rules, underlying chemistry and the fundamental principles of multivalency. The systems covered range from chemical/materials-based ones such as dendrimers and sensors, to biological systems including cell recognition and protein binding. Examples and case studies from biochemistry/bioorganic chemistry as well as synthetic systems feature throughout the book. Introduces students and young scientists to the field of multivalent interactions and assists experienced researchers utilising the methodologies in their work Features examples and case studies from biochemistry/bioorganic chemistry, as well as synthetic systems throughout the book Edited by leading experts in the field with contributions from established scientists Multivalency: Concepts, Research & Applications is recommended for graduate students and junior scientists in supramolecular chemistry and related fields, looking for an introduction to multivalent interactions. It is also highly useful to experienced academics and scientists in industry working on research relating to multivalent and cooperative systems in supramolecular chemistry, organic chemistry, pharmaceutical chemistry, chemical biology, biochemistry, materials science and nanotechnology.
Integrating Project Delivery
A revolutionary, collaborative approach to design and construction project delivery Integrating Project Delivery is the first book-length discussion of IPD, the emergent project delivery method that draws on each stakeholder's unique knowledge to address problems before they occur. Written by authors with over a decade of research and practical experience, this book provides a primer on IPD for architects, designers, and students interested in this revolutionary approach to design and construction. With a focus on IPD in everyday operation, coverage includes a detailed explanation and analysis of IPD guidelines, and case studies that show how real companies are applying these guidelines on real-world projects. End-of-chapter questions help readers quickly review what they've learned, and the online forum allows them to share their insights and ideas with others who either have or are in the process of implementing IPD themselves. Integrating Project Delivery brings together the owners, architect, engineers, and contractors early in the development stage to ensure that problems are caught early, and to address them in a collaborative way. This book describes the parameters of this new, more efficient approach, with expert insight on real-world implementation. Compare traditional procurement with IPD Understand IPD guidelines, and how they're implemented Examine case studies that illustrate everyday applications Communicate with other IPD adherents in the online forum The IPD approach revolutionizes not only the workflow, but the relationships between the stakeholders – the atmosphere turns collaborative, and the team works together toward a shared goal instead of viewing one another as obstructions to progress. Integrated Project Delivery provides a deep exploration of this approach, with practical guidance and expert insight.
Atomic Layer Deposition. Principles, Characteristics, and Nanotechnology Applications
Since the first edition was published in 2008, Atomic Layer Deposition (ALD) has emerged as a powerful, and sometimes preferred, deposition technology. The new edition of this groundbreaking monograph is the first text to review the subject of ALD comprehensively from a practical perspective. It covers ALD's application to microelectronics (MEMS) and nanotechnology; many important new and emerging applications; thermal processes for ALD growth of nanometer thick films of semiconductors, oxides, metals and nitrides; and the formation of organic and hybrid materials.
Handbook of Global Education Policy
This innovative new handbook offers a comprehensive overview of the ways in which domestic education policy is framed and influenced by global institutions and actors. Surveys current debates about the role of education in a global polity, highlights key transnational policy actors, accessibly introduces research methodologies, and outlines global agendas for education reform Includes contributions from an international cast of established and emerging scholars at the forefront of the field thoughtfully edited and organized by a team of world-renowned global education policy experts Each section features a thorough introduction designed to facilitate readers’ understanding of the subsequent material and highlight links to interdisciplinary global policy scholarship Written in an accessible and engaging style that will appeal to domestic and international policy practitioners, social scientists, and education scholars alike
Flavour. From Food to Perception
This book will cover all aspects of flavour perception, including aroma, taste and the role of the trigeminal nerve, from the general composition of food to the perception at the peri-receptor and central level. This book will answer to a growing need for multidisciplinary approaches to better understand the mechanisms involved in flavour perception. The book presents the bases of anatomy of sensory perception. It will provide the requisite basic knowledge on the molecules responsible for flavour perception, on their release from the food matrix during the eating process in order to reach the chemosensory receptors, and on their retention and release from and transformation by bodily fluids of the oral and nasal cavities. It will also bring current knowledge on the multimodal interactions. This book will also cover the recent evolution in flavour science: characterisation of molecules, interaction with food matrix and more recently, physic-chemical and physiological and events during oral processing increasingly considered.
The CSA Exam. Maximizing your Success
First Prize in Primary health care in the 2017 BMA Medical Book Awards Written by a team of practising GPs and CSA examiners, in collaboration with the recent CSA Role-Player Lead responsible for training and quality-assuring the work of the simulated patients in the exam, The CSA Exam: Maximizing your Success is a key resource for trainees and their trainers, in preparing for this component of the MRCGP assessment. Designed to help readers prepare and master the knowledge, skills, and attitudes needed to pass, it focuses on what is truly expected by examiners and demystifies all aspects of the exam. Giving insight into how candidates and trainers can maximize their potential, The CSA Exam: Maximizing your Success includes: • Essential Learning Points, and Hints and Tips on ‘Getting Started’, ‘The Consultation’ and ‘On the Day’ • Advice on applying an ethical approach to consultations and dealing with possible areas of concern • A variety of cases, to help practise exam technique and to aid candidates in the creation of their own cases • A companion website at www.wiley.com/go/Roberts/CSAExam featuring 18 video clips to accompany the written cases and marking schemes Taking an approach to preparation which looks at the candidate, simulated patients and the assessment itself, The CSA Exam: Maximizing your Success provides MRCGP candidates and GP trainers with an invaluable and unique resource for success in the exam.
Das Ende der Nacht. Lichtsmog: Gefahren - Perspektiven - Lösungen
Every city dweller is aware that we are seeing fewer stars at night due to the increasing amount of artificial lighting. But that is just the tip of the iceberg, as far as the loss of natural nocturnal darkness is concerned. Humans and animals worldwide are now suffering from the disrupted rhythm of day and night due to extreme lighting at night. In humans this can lead to illness and increased stress. Hitherto only known to experts, this book is the first to comprehensively treat the entire phenomenon of light pollution. Richly illustrated using unusual images taken from the TV documentation «The Dark Side of Light» by Anja Freyhoff and Thomas Uhlmann, this book is for anyone interested in a harmonious coexistence between humans and nature and a healthy work/life rhythm.
Culturally Responsive Counseling With Latinas/os
This book provides culture-centered assessment and intervention strategies for effective clinical practice with Latina/o individuals and families. Mental health professionals will gain new and expanded cultural competence as they learn to sensitively and ethically integrate Latino values into their work. Throughout the text, case scenarios illustrate ways to work successfully with clients of all ages. A sample culture-centered clinical interview is included, along with a listing of Latino-specific mental health resources. Topics discussed include roles, relationships, and expectations in Latino families; cultural and bicultural values; gender role socialization; generational differences; identity and acculturation issues; educational values and achievement; Latinas/os in the workforce; and religious beliefs and practices. *Requests for digital versions from the ACA can be found on wiley.com. *To request print copies, please visit the ACA website.