Прочая образовательная литература
Различные книги в жанре Прочая образовательная литератураThe Science and Engineering of Thermal Spray Coatings
This extensively updated and revised version builds on the success of the first edition featuring new discoveries in powder technology, spraying techniques, new coatings applications and testing techniques for coatings – Many new spray techniques are considered that did not exist when the first edition was published! The book begins with coverage of materials used, pre-spray treatment, and the techniques used. It then leads into the physics and chemistry of spraying and discusses coatings build-up. Characterization methods and the properties of the applied coatings are presented, and the book concludes with a lengthy chapters on thermal spray applications covers such areas as the aeronautics and space, automobiles, ceramics, chemicals, civil engineering, decorative coatings, electronics, energy generation and transport, iron and steel, medicine, mining and the nuclear industries.
Introduction to Chemicals from Biomass
Nature provides us with an abundance of chemical potential. Presenting an overview of the use of bioresources in the 21st century, Introduction to Chemicals from Biomass covers resources, chemical composition of biomass, key factors affecting composition, utilization of wastes, extraction technologies, controlled pyrolysis, fermentation, platform molecules, and green chemical technologies for their conversion to valuable chemicals. The text shows how smaller volume chemicals could become bulk chemicals as a result of a greater exploitation of biomass products, making it an important resource for academic and industrial scientists and researchers.
Protein Targeting with Small Molecules
Discover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides. Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications: Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules
Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels
This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
Nuclear Receptors in Drug Metabolism
This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.
Pathway Analysis for Drug Discovery
This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.
Medical Toxicology of Natural Substances
Interest and information in the field of medical toxicology has grown rapidly, but there has never been a concise, authoritative reference focused on the subjects of natural substances, chemical and physical toxins, drugs of abuse, and pharmaceutical overdoses. Medical Toxicology of Natural Substances finally gives you an easily accessible resource for vital toxicological information on foods, plants, and animals in key areas in the natural environment.
Drug Metabolism in Drug Design and Development
The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
Vaccine Adjuvants and Delivery Systems
The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.
New Drug Discovery and Development
A case history approach to drug synthesis and discovery Discover the origins of some of today’s most popular drug therapies. Explore case histories and gain insight into major classes of antibiotics, antiviral drugs, analgesics, steroids, compounds designed to lower cholesterol, and more. Review the steps required for FDA approval. This is a great reference for students in medicinal chemistry, researchers in pharmaceuticals, and medical practitioners.