Get a good start in flavor and fragrance chemistry! This book presents a survey of those natural and synthetic fragrance and flavor materials which are isolated and produced commercially on a relatively large scale because of their organoleptic characteristics. It provides information on their properties, methods employed in their manufacture, and their areas of application. '…The excellent and concise introduction to this unique industry is followed by extensive information on nearly 500 of the most used fragrance and flavor compounds. Names, molecular formula, physical data, odor and flavor descriptions, uses, and a number of processes for the larger volume chemicals are all included. Successive chapters deal with essential oils, animal secretions, quality control, toxicology and literature. The formula, name and CAS registry number index is an invaluable and timely addition.' Parfumer and Flavorist '…This book provides a lot of useful information in one place, and it is an especially good resource for somebody just entering the flavor and fragrance industry.' Journal of Medicinal Chemistry 'You'll find much information in this book not found in other works.' Foster's Herb Business Bulletin 'Particularly useful for natural product chemists, those in the product development and the curious.' Herbalgram
This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands – all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.
Bei der Herstellung von Produkten und Verbrauchsgutern in verfahrenstechnischen Produktionsanlagen ist die Kristallisation ein wesentlicher Verfahrensschritt, um bei Stofftrennprozessen eine hohe Reinheit zu erzielen. Diese Stofftrennungsschritte verursachen haufig einen gro?en Teil der Anlagenbetriebs- und Investitionskosten. Das Buch vermittelt auf klare und verstandliche Weise die Planungsgrundlagen und Beurteilungskriterien fur Kristallisationsverfahren in der industriellen Chemie. Mit diesem Buch wird vor allem der Praktiker in der Industrie angesprochen, der sich schnell und zielgerichtet uber das Thema informieren mochte. Das Buch gibt eine generelle Einfuhrung in die theoretischen Grundlagen, behandelt aber vor allem Praxisbeispiele aus der Industrie. Aus dem Inhalt: Einfuhrung Gleichgewichtsdiagramme fur die Kristallisation aus Losungen und Schmelzen Keimbildung und Kristallwachstum Grundlagen der technischen Kristallisation Partikelgro?enverteilung und Modellierung von Kristallisatoren Agglomeration Druck-Kristallisation Diskontinuierliche Kristallisationsprozesse Fremdstoffbeeinflussung in der Kristallisation Verfahren und Kristallisatorbauarten fur die einfache Kristallisation aus Losungen Fallbeispiele ausgefuhrter Anlagen Verfahren und Apparate zur Kristallisation aus Schmelzen
A guide for younger R&D chemists as to how they can quickly evolve skills built around three factors – people, knowledge and time. It covers the management of scientific personnel, management within a variety of R & D organizational structures, creating a climate of innovation, the management of projects including the time management and communication aspects of the job. As such, it teaches the vital managerial aspects of scientific jobs in industry, which are not taught at university, providing a deep and detailed insight into the intricacies of managing research. The text is divided neatly into four sections: * Harnessing the Human Resource * Organising for an Innovative Environment * Creativity and Innovation * Project Management of Innovation The author, Peter Bamfield, is now working as a consultant. Due to his long experience in the chemical industry, he was elected President of the Royal Society of Chemistry's Industrial Affairs Division, and thus has a profound first-hand view of staff, companies and organizations in and around the industry. This third edition has been revised and updated to take into account global developments and recent changes in regulatory affairs.
This first comprehensive handbook on the subject describes the manufacturing processes of various types of papers, recovered paper treatment, as well as the quality and economical aspects. More than 20 authors contribute a variety of viewpoints, one of the many features of this book. They give a concise description of the fascinating art and technology of papermaking, providing lay readers, students, politicians and others with the latest information on current technologies. From the contents: * Introduction * Raw materials * Stock preparation * Water and reject handling * Paper and board manufacturing * Coating * Paper dyeing * Paper and board grades and their properties * Testing of paper and board * Paper and book preservation. Of great interest to all engineers and chemists in the paper industry and related areas.
Get a good start in flavor and fragrance chemistry! This book presents a survey of those natural and synthetic fragrance and flavor materials which are commercially available, produced and used on a relatively large scale and which are important ingredients for the creation of fragrance and flavor compositions because of their specific sensory characteristics, e.g., smell, taste. It provides information on their properties, methods employed in their manufacture, and their areas of application. This is the 5th edition of the classic «Bauer-Garbe». '…The excellent and concise introduction to this unique industry is followed by extensive information on nearly 500 of the most used fragrance and flavor compounds. Names, molecular formula, physical data, odor and flavor descriptions, uses, and a number of processes for the larger scale production of chemicals are all included. Successive chapters deal with essential oils, animal secretions, quality control, toxicology and literature. The formula, name and CAS registry number index are an invaluable and timely addition.' – Parfumer and Flavorist '…Data that would normally have to be selected from many different books are available in one source with this book…with over 800 citations throughout the text, this is a nearly inexhaustible source of information.' – Euromaterials
Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.
Mastering management skills is hard to achieve by newcomers starting their careers in the chemical industry. The message coming from there is that good chemists swiftly have to become good managers if they are to survive and progress in today's competitive climate. This book is designed to help guide younger R & D chemists to ways in which they can quickly evolve skills which are built around three factors – people, knowledge and time. It covers the management of scientific personnel, management within a variety of R & D organisational structures, creating a climate of innovation, the management of projects including the time management and communication aspects of the job. The author, Peter Bamfield, is now working as a consultant. Due to his long experience in the chemical industry, he was elected President of the Royal Society of Chemistry's Industrial Affairs Division. This second edition of the book has been revised and updated to take recent global developments and restructuring in the chemical industry into account, as well as the rising importance of information technology in management.
Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body. To overcome this problem, stable and at the same time biologically active pseudo-peptides have been developed. These novel compounds open up new perspectives in drug design by providing an entire range of highly specific and non-toxic pharmaceuticals. This is the first work devoted to the topic and draws together knowledge gained on different types of peptidomimetics and other pseudo-peptides with drug properties. As such, it includes peptoids, beta-peptides, polyamide DNA binders as well as peptide nucleic acids. The expert authors and editor discuss chemical properties and stability, biological activity and reactivity, as well as practical aspects of synthesis, making this a prime resource for drug developers and bioorganic chemists working with these compounds.