The Almería Province of SE Spain, a semi-arid, tectonically active region, is the focus of a wide range of scientific teaching and research in the earth sciences by universities and associated bodies from around the world. This field guide provides an up-to-date and integrated approach to the geology and geomorphology of Almería Province, compiled by active scientific researchers in the region. The guide assumes a basic knowledge of geology and geomorphology and will be of interest to earth scientists at all levels from the keen amateur through to undergraduate/postgraduate students and academics visiting the region. The guide provides general background on the area, followed by a selection of specialized trips that progressively explore the structure and development of the basins, the shallow marine sedimentation, the continental sedimentation and finally the uplift, dissection and geomorphic evolution of the sedimentary basins. This is the first widely published field guide on the Almería Province and it is unique in both its coverage and integrated earth science approach, providing valuable support for both teaching and research in the region. If you are a member of the International Association of Sedimentologists, for purchasing details, please see: http://www.iasnet.org/publications/details.asp?code=FG1
Nowadays cell culture is part of the tools used in all bio-professions, whether in research, industry or clinics. The author, the manager of a cell culture company, explains the main aspects in a clear and readily comprehensible manner. An overview of the most important instruments, materials and nutrients, the basic rules of sterile working, as well as a description of the most common problems and how to solve them quickly equip trainees, students and specialists (again) for the cell laboratory. Includes a glossary of all important technical terms.
Meeting the need for a book on developing and using new methods to investigate membrane proteins, this is the first of its kind to present the full range of novel techniques in one resource. Top researchers from around the world focus on the physical principles exploited in the different techniques, and provide examples of how these can bring about important new insights. Following an introduction, further sections discuss structural approaches, molecular interaction and large assemblies, dynamics and spectroscopies, finishing off with an exploration of structure-function relationships in whole cells.
This book supplies an application-oriented introduction to molecular simulation techniques used to study a wide range of problems in molecular biology. Each chapter focuses in detail on one kind of application, including the scientific background, the appropriate methodology and the relationship to experimental results. The book contains many areas of interest to basic and industrial scientists, including: – flexibility of peptides – protein-peptide interactions – ion translocation across membranes – modelling protein and nucleic acid conformations – stability of mutant proteins – modelling conformational transitions Currently the only up-to-date compilation available, this book enables readers to get an overview of the methods and how they are used in various specialized applications without having to search for them in a large number of papers in different journals.
It is unlikely that the established genomes of present day organisms remain stable forever. It is conceivable that foreign DNA can gain entry into individual cells of an organism. Foreign DNA is defined as genetic material that derives from another organism of the same or a different species. The natural environment is heavily «contaminated» with such foreign DNA, and mammals, like other organisms, are frequently exposed to foreign DNA in their environment, notably by ingesting their daily food supply. By necessity, the gastrointestinal tract also of all mammalian organisms is constantly in contact with foreign DNA. So far, next to nothing is known about defense mechanisms in mammals against the intrusion of foreign DNA. At least in cells growing in culture, the uptake and genomic fixation by integration of foreign DNA can readily be demonstrated. For a number of reasons, the author has considered it important to investigate the phenomena and mechanisms involved in the interaction of foreign DNA with mammalian cells and organisms in detail.
Senatskommission für Grundsatzfragen der Genforschung
Wie die vorherigen Stellungnahmen und Empfehlungen der DFG zur Stammzellforschung von 1999 und 2001 wird sicherlich auch diese eine lebhafte Debatte in Politik, Wissenschaft und Öffentlichkeit auslösen.
This first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also covering emerging infectious diseases, such as tuberculosis. Edited by one of the authors of a groundbreaking paper on this topic.