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    Bioinformatics for Vaccinology

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    “… this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once…” Human Vaccines, 2010 «… This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies… This book may well serve as a first line of reference for all biologists and computer scientists…» –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

    Human Blood Groups

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    Human Blood Groups is a comprehensive and fully referenced text covering scientific and clinical aspects of red cell surface antigens, including: serology inheritance biochemistry molecular genetics biological functions clinical significance in transfusion medicine Over a century has passed since Landsteiner discovered the human blood groups, making the practice of blood transfusion possible. Yet, in the six years since the first edition of Human Blood Groups was published, new blood groups have been discovered, several blood group genes have been cloned, and the molecular backgrounds of numerous blood group variants have been worked out. All this new information has made the production of a second edition of Human Blood Groups timely. This book is an essential reference source for all those working in the field of blood transfusion and blood banking.

    Stable Isotope Forensics

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    This book provides the first comprehensive, overview and guide to forensic isotope analysis, an exciting new application of stable isotope analytical techniques. Topics are introduced using examples and real-life case studies such as food quality control where isotope analysis has already had a major impact, in terms of consumer protection, These examples illustrate the underlying principles of isotope profiling or fingerprinting. A section comprising actual criminal case work is used to build a bridge between the introduction and the technical section to encourage students to engage with this novel departure for analytical sciences while at the same time providing hands-on examples for the experienced researcher and forensic practitioner to match problems and success stories encountered with the topics discussed in the technical section. What little information is available on the subject in book form so far, has been published as individual chapters in books dealing either with mass spectrometry, forensic geoscience or environmental forensics, this is the first book to focus on the entire spectrum of forensic isotope analysis and will be an invaluable reference to both researchers in the field and forensic practitioners.

    Practical Diabetes Care

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    Concise, affordable and extremely practical, Practical Diabetes Care, 4th edition offers a wholly clinical approach to diabetes and its treatment. Covering all the practical aspects of all major aspects of Type 1 and Type 2 diabetes, it also includes the very latest in clinical research and trial results. Structured in a problem-orientated way, the book focuses on the areas of maximum anxiety for health-professionals treating patients with diabetes, e.g. hyperglycaemic emergencies, and multiple complications. Easy to navigate, clear and convenient for when on the wards and in clinic, this is the perfect guide to the practical aspects of caring for patients with diabetes.

    Emergencies in Diabetes

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    While diabetes can usually be well-controlled using modern therapies, metabolic emergencies inevitably occur. This book provides an easy-to-read yet comprehensive account of emergencies in diabetes conveniently collected into one volume. For each topic, a brief review of the pathophysiology is followed by a description of cardinal clinical features, clinical and biochemical assessment and clinical management. Clear, informative text for rapid and easy assimilation Emphasis on evidence-based medicine Effective use of illustrations to highlight and summarize key points Designed to fit conveniently into the pocket of a white coat, this book should be readily to hand in all hospital medical wards, particularly A&E. It will be useful to junior hospital doctors across a wide range of specialties, senior house officers in general medical training, and nurses involved in the care of patients with diabetes.

    Handbook of Psoriasis

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    The new second edition of the Handbook of Psoriasis remains an easy-to-read but detailed text on a common skin disease which affects 2% of the world's population. The text is designed as a reference for both the specialist and the primary care physician and can be read cover-to-cover in a week. Each chapter stands alone as a reference to a specific topic but is clearly cross-referenced to offer a more detailed perspective. This new edition runs the full gamut from pathogenesis to clinical variants of psoriasis to individual treatments with emphasis on standard protocols. Each chapter has been carefully updated to reflect developments in the last five years and new chapters cover such topics as childhood psoriasis, psoriatic arthritis and biologic immunotherapy.

    Practical ECG Interpretation

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    Practical ECG Interpretation draws on Dr. Stouffer's clinical experience to identify specific tracings and findings that will aid diagnosis of a wide variety of disorders, incluidng atrial spetal defect, mitral stenosis, pericarditis, and more.

    Handbook of Hypertension

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    When treating hypertension, physicians now have a huge range of drugs from which to choose in formulating a management strategy. This accessible guide helps the busy clinician access specific information on available drugs as components of an integrated care plan. The Handbook of Hypertension is a comprehensive review of the evidence base for hypertension and associated disease, providing tables, figures, charts, and summaries of principal findings from clinical studies on hypertension – putting vital information within reach of the busy practitioner. Containing the most recent guidelines for global cardiovascular risk analysis and evidence-based reviews on important new advances and recent trials, consulting the Handbook of Hypertension will save precious time and improve patient care.

    Pulmonary Arterial Hypertension

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    First book dedicated to this disease, previously thought to be incurable, but with the advent of new drugs, now amenable to management and a much improved prognosis for patients From the PAH Association, the leading experts in field Incorporates the latest AACP management guidelines Includes evidence-based treatment algorithms based on the recently updated ACCP Guidelines for Medical Treatment Aimed at specialists in pulmonology and cardiovascular disease, this volume provides the clinician with the most up to date information on the effective management of PAH

    150 Practice ECGs

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    The third edition of 150 Practice ECGs: Interpretation and Review combines practice tracings with clinical cardiology, providing students with the practical knowledge necessary to read, interpret, and understand ECGs. This essential review book is organized into three sections: introductory text reviewing ECG diagnostic criteria, pathophysiology, and clinical correlation; 150 ECG tracings with a brief clinical history; and interpretation and teaching points for each of the 150 ECGs. 150 Practice ECGs: Interpretation and Review, 3rd Edition is ideal as an introductory text for medical and nursing students at any stage of training, for residents and fellows as a refresher before board exams, and for the sophisticated student/teacher as a comprehensive teaching file.