Bioprospecting of Microorganism-Based Industrial Molecules. Группа авторов

synthetically derived gelling agents, or silicone‐derived ingredients. These compounds provide moisturizing and have antioxidant properties; hence they are used as gelling agents and stabilizers in emulsions [85, 86] (Table 4.2).

Table 4.2 Algal biomolecules, sources, origins, and applications in cosmetics.

      Source: Wang et al. [85] and Wang et al. [86].

Group of compound	Active compound	Algal species	Cosmetic properties	References
Polysaccharides	Agar	Gelidium sp.Gracilaria sp.	Emulsion stabilizers, gelling agents, thickeners	[87–89]
	Alginates	Laminaria sp.Lessonia sp.Macrocystis sp.	Emulsion stabilizers, chelating agents, gelling, moisturizing, photo‐protective	[8490–92]
	Fucoidan	Saccharina sculpera Fucus vesiculosus, Turbinariaconoides, Undaria pinnatifida	Antiaging, anti‐wrinkle, antioxidative properties, UV protectant, skin lightening, spot reduction, elastase, tyrosinase inhibitors, skin fibroblast stimulation	[93–97]
	Laminarans	Laminaria japonica, Ecklonia kurome, Eiseniabicyclis, Saccharina, Ascophyllum, Fucus, Sargassum, and Undaria	Antioxidant, anti‐cellulite agent	[81, 98, 99]
	Porphyran	Porphyra sp.	Antioxidant and antiaging	[78, 88, 93, 100]
	Carrageenan	Acanthophora muscoidesChondrus crispus	Gelling agents, protective colloids, thickeners	[101–103]
	Ulvan	Ulva armoricana, Ulva lactuca, Ulva rotundata, and Ulva rigida	Antioxidative, chelating, gelling, moisturizing, and protective agents	[88, 104, 105]
Pigments	Astaxanthin	Haematococcus pluvialis	Antiaging	[106]
	β‐carotene	Chlorella, Spirulina, Dunaliella salina	Antiaging, antioxidant, radical scavengers, anti‐photoaging agents, and colorants	[88107–111]
	Chlorophylls(a, b, c, d)	Chlorella, Nannochloropsis	Coloring agents, UV‐protectant, reduce inflammation, Reducing wrinkles, inhibiting matrix metalloproteinases (MMPs)	[88, 92,112–114]
	Fucoxanthin	Fucus, Dictyota, Saragassum, and Laminaria	Anti‐tyrosinase activity in guinea pig UVB irradiated, and melanogenesis in mice UVB irradiated	[88115–117]
	Phycobiliproteins(APC, PE, PC)	Cyanobacteria	Antioxidant, anti‐inflammatory, colorants, radical scavenging agents	[88, 97,118–121]
Secondary metabolites	Phlorotannins	Ecklonia cava, Eiseniabicyclis	Tyrosinase and hyaluronidase inhibitors, antioxidants, antiaging, UV‐photoprotectant, chelating agents	[79, 88, 122]
Mycosporine‐like amino acids (MAAs)	Scytonemin, Asterina‐330, Shinorine, PalythinePorphyra‐334	Scytonema, Lyngbya, Porphyra umbilicalis	Photo‐protectant, sunscreen against UV‐A	[79, 111,122–124]

      4.4.4.2 Fucoidan

      Fucoidans are heteropolysaccharides containing L‐fucose sugar and sulfate ester groups [10]. They are mostly derived from the brown seaweed. In some seaweeds, along with fucose sugar, other sugars such as glucose, galactose, mannose, xylose, and glucuronic acid (GlcA) have also been reported [125]. The application of fucoidans in the cosmetic industry has been widely investigated. Numerous study has been carried on the inhibitory aspects of topical application of fucoidans on the skin against aging and photo‐damaged effects [93, 94, 115]. Fucoidans are known to enhance multiplication skin fibroblast and augment the retention of native collagen [95, 126]. Fucoidans are known to protect the elastic fiber network in human dermal cells, and hence they are used as a natural whitening agent in lotion and skin creams to reduce age spot and increased radiance, increase smooth texture skin [96, 127]. In human skin, melanocytes cells are known to impart the skin complexion. The pigment melanin is produced and stored inside the melanocytes and is primarily obtained from amino acid L‐tyrosine, which is converted to dopaquinone by the action of the enzyme tyrosinase. Hence, suppression of tyrosinase‐related proteins plays an important role in anti‐melanogenesis and skin whitening [128]. In this regard, several studies have demonstrated the inhibition of enzyme tyrosinase, antioxidant activity, and anti‐melanogenesis of fucoidan fraction from various macroalgae [96, 128, 129]. Furthermore, the property of fucoidans to readily solubilize in water makes it attractive to combine into several ranges of cosmetic formulations such as lotions, creams, ointments, and other beauty products.

      4.4.4.3 Laminaran

      Laminaran is also widely known as laminarin or leucosin. Laminarin is a glucan polysaccharide made up of β(1→3)‐glucan with β(1→6)‐branches with a β(1→3):β(1→6) in the ratio of 3:1. They are obtained from brown seaweeds Laminaria japonica, E. kurome, Eiseniabicyclis, Saccharina, Ascophyllum, Fucus, Sargassum, and Undaria species. Several reports have confirmed to have anticancerous, anti‐inflammatory, anticoagulant, and antioxidant properties in laminarin extracts of seaweeds [87]. Laminarin is widely used as filler composition in cosmetic products for the treatment of wrinkles, folds, and as anti‐cellulite agents [98, 99].

      4.4.4.4 Ulvans

      Ulvans are cell wall polysaccharide derived from the genus Ulva (Ulvaarmoricana, Ulvalactuca, Ulvarotundata, and Ulvarigida) of green macroalgae belonging to the Chlorophyta group. Ulvan roughly contributes from 9 to 36% dry