Genome Transcriptome and Proteome Analysis is a concise introduction to the subject, successfully bringing together these three key areas of research. Starting with a revision of molecular genetics the book offers clear explanations of the tools and techniques widely used in genome, transcriptome and proteome analysis. Subsequent chapters offer a broad overview of linkage maps, physical maps and genome sequencing, with a final discussion on the identification of genes responsible for disease. An invaluable introduction to the basic concepts of the subject, this text offers the student an excellent overview of current research methods and applications and is a good starting point for those new to the area. A clear, concise introduction to the subject of modern genomic analysis A technology-oriented approach including the latest developments in the field Invaluable to those students taking courses in Bioinformatics, Human Genetics, Biochemistry and Molecular Biology
An Introduction to Forensic Genetics is a comprehensive introduction to this fast moving area from the collection of evidence at the scene of a crime to the presentation of that evidence in a legal context. The last few years have seen significant advances in the subject and the development and application of genetics has revolutionised forensic science. This book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field, illustrated throughout with references to relevant casework. In addition to the technology involved in generating a DNA profile, the underlying population biology and statistical interpretation are also covered. The evaluation and presentation of DNA evidence in court is discussed as well with guidance on the evaluation process and how court reports and statements should be presented. An accessible introduction to Forensic Genetics from the collection of evidence to the presentation of that evidence in a legal context Includes case studies to enhance student understanding Includes the latest developments in the field focusing on the technology used today and that which is likely to be used in the future Accessible treatment of population biology and statistics associated with forensic evidence This book offers undergraduate students of Forensic Science an accessible approach to the subject that will have direct relevance to their courses. An Introduction to Forensic Genetics is also an invaluable resource for postgraduates and practising forensic scientists looking for a good introduction to the field.
A indispensable guide to understanding and designing modern experiments The tools and techniques of Design of Experiments (DOE) allow researchers to successfully collect, analyze, and interpret data across a wide array of disciplines. Statistical Analysis of Designed Experiments provides a modern and balanced treatment of DOE methodology with thorough coverage of the underlying theory and standard designs of experiments, guiding the reader through applications to research in various fields such as engineering, medicine, business, and the social sciences. The book supplies a foundation for the subject, beginning with basic concepts of DOE and a review of elementary normal theory statistical methods. Subsequent chapters present a uniform, model-based approach to DOE. Each design is presented in a comprehensive format and is accompanied by a motivating example, discussion of the applicability of the design, and a model for its analysis using statistical methods such as graphical plots, analysis of variance (ANOVA), confidence intervals, and hypothesis tests. Numerous theoretical and applied exercises are provided in each chapter, and answers to selected exercises are included at the end of the book. An appendix features three case studies that illustrate the challenges often encountered in real-world experiments, such as randomization, unbalanced data, and outliers. Minitab® software is used to perform analyses throughout the book, and an accompanying FTP site houses additional exercises and data sets. With its breadth of real-world examples and accessible treatment of both theory and applications, Statistical Analysis of Designed Experiments is a valuable book for experimental design courses at the upper-undergraduate and graduate levels. It is also an indispensable reference for practicing statisticians, engineers, and scientists who would like to further their knowledge of DOE.
The mapping of human genes is proceeding rapidly. Genes associated with specific inherited diseases are being identified, often providing insight into the molecular cause of the disease. At the moment, however, little consideration is being given to the variation present in different human populations. Variation in the Human Genome discusses methods of analysing population genetic data and how contemporary genetic heterogeneity arises during the evolution and migration of human populations. Specific disorders such as cystic fibrosis, beta-thalassaemia, fragile X, phenylketonuria and tumour development susceptibility are used to illustrate this genetic variability and mechanisms of gene mutation and evolution.
The growth of the environmental sciences has greatly expanded the scope of biological disciplines today's engineers have to deal with. Yet, despite its fundamental importance, the full breadth of biology has been given short shrift in most environmental engineering and science courses. Filling this gap in the professional literature, Environmental Biology for Engineers and Scientists introduces students of chemistry, physics, geology, and environmental engineering to a broad range of biological concepts they may not otherwise be exposed to in their training. Based on a graduate-level course designed to teach engineers to be literate in biological concepts and terminology, the text covers a wide range of biology without making it tedious for non-biology majors. Teaching aids include: * Notes, problems, and solutions * Problem sets at the end of each chapter * PowerPoints(r) of many figures A valuable addition to any civil engineering and environmental studies curriculum, this book also serves as an important professional reference for practicing environmental professionals who need to understand the biological impacts of pollution.
Economics, Ethics, and Environmental Policy: Contested Choices offers a comprehensive analysis of the ethical problems associated with basing environmental policy on economic analysis, and ways to overcome these problems.
Based on a fifty-year study conducted by the Leibniz Institute for Baltic Sea Research, this book brings together a comprehensive summary of their observations and findings. Written by well-known experts, this revealing book concentrates on long-term changes in the Baltic Sea?which can be extrapolated to shed light on the environmental problems of other shelf seas, brackish seas, and large estuaries?thereby contributing to our understanding of water exchange processes, eutrophication, and climatic impacts at the forefront of international concern.
This is the first comprehensive monograph that features state-of-the-art multigrid methods for enhancing the modeling versatility, numerical robustness, and computational efficiency of one of the most popular classes of numerical electromagnetic field modeling methods: the method of finite elements. The focus of the publication is the development of robust preconditioners for the iterative solution of electromagnetic field boundary value problems (BVPs) discretized by means of finite methods. Specifically, the authors set forth their own successful attempts to utilize concepts from multigrid and multilevel methods for the effective preconditioning of matrices resulting from the approximation of electromagnetic BVPs using finite methods. Following the authors' careful explanations and step-by-step instruction, readers can duplicate the authors' results and take advantage of today's state-of-the-art multigrid/multilevel preconditioners for finite element-based iterative electromagnetic field solvers. Among the highlights of coverage are: * Application of multigrid, multilevel, and hybrid multigrid/multilevel preconditioners to electromagnetic scattering and radiation problems * Broadband, robust numerical modeling of passive microwave components and circuits * Robust, finite element-based modal analysis of electromagnetic waveguides and cavities * Application of Krylov subspace-based methodologies for reduced-order macromodeling of electromagnetic devices and systems * Finite element modeling of electromagnetic waves in periodic structures The authors provide more than thirty detailed algorithms alongside pseudo-codes to assist readers with practical computer implementation. In addition, each chapter includes an applications section with helpful numerical examples that validate the authors' methodologies and demonstrate their computational efficiency and robustness. This groundbreaking book, with its coverage of an exciting new enabling computer-aided design technology, is an essential reference for computer programmers, designers, and engineers, as well as graduate students in engineering and applied physics.
Applied Electromagnetics and Electromagnetic Compatibility deals with Radio Frequency Interference (RFI), which is the reception of undesired radio signals originating from digital electronics and electronic equipment. With today's rapid development of radio communication, these undesired signals as well as signals due to natural phenomena such as lightning, sparking, and others are becoming increasingly important in the general area of Electro Magnetic Compatibility (EMC). EMC can be defined as the capability of some electronic equipment or system to be operated at desired levels of performance in a given electromagnetic environment without generating EM emissions unacceptable to other systems operating in the vicinity.
The applications of electromagnetic phenomena within electrical engineering have been evolving and progressing at a fast pace. In contrast, the underlying principles have been stable for a long time and are not expected to undergo any changes. It is these electromagnetic field fundamentals that are the subject of discussion in this book with an emphasis on basic principles, concepts and governing laws that apply across the electrical engineering discipline. Electromagnetic Foundations of Electrical Engineering begins with an explanation of Maxwell’s equations, from which the fundamental laws and principles governing the static and time-varying electric and magnetic fields are derived. Results for both slowly- and rapidly-varying electromagnetic field problems are discussed in detail. Key aspects: Offers a project portfolio, with detailed solutions included on the companion website, which draws together aspects from various chapters so as to ensure comprehensive understanding of the fundamentals. Provides end-of-chapter homework problems with a focus on engineering applications. Progresses chapter by chapter to increasingly more challenging topics, allowing the reader to grasp the more simple phenomena and build upon these foundations. Enables the reader to attain a level of competence to subsequently progress to more advanced topics such as electrical machines, power system analysis, electromagnetic compatibility, microwaves and radiation. This book is aimed at electrical engineering students and faculty staff in sub-disciplines as diverse as power and energy systems, circuit theory and telecommunications. It will also appeal to existing electrical engineering professionals with a need for a refresher course in electromagnetic foundations.