Brings together the latest research in the cellular and molecular biology of bones and teeth, including applications to medical and dental practice. An interdisciplinary group of contributors addresses control of bone formation, resorption and remodelling, osteoblast differentiation and osteoclast activity, factors influencing dental extracellular matrix biomineralization, non-collagen proteins in bone and their function, hormonal regulation of bone growth, and more.
Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers. Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers Offers clinicians summary presentation of state-of-the-art science of DNA microarrays Each chapter includes bibliographic and further reading suggestions Easily accessible, assuming no special training in statistics or bioinformatics Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.
This advanced level textbook provides a comprehensive overview of recent developments in the area of molecular based diagnostics (including nucleic acids, biosensors and immunoessays) of disease markers. It also covers the impact of techniques such as in vitro nucleic acid amplifications (e.g. PCR) and other amplification methods, as well as gene and biochip production and automated techniques such as fluorescent sequencing. The book discusses key concepts where new and merging areas, including pharmacogenomics, proteomics and functional genomics, are being researched and developed. In addition, examples are given where this new area of bioscience has or may be successfully applied.
Computational fluid dynamics (CFD) is concerned with the efficient numerical solution of the partial differential equations that describe fluid dynamics. CFD techniques are commonly used in the many areas of engineering where fluid behavior is an important factor. Traditional fields of application include aerospace and automotive design, and more recently, bioengineering and consumer and medical electronics. With Applied Computational Fluid Dynamics Techniques, 2nd edition, Rainald Löhner introduces the reader to the techniques required to achieve efficient CFD solvers, forming a bridge between basic theoretical and algorithmic aspects of the finite element method and its use in an industrial context where methods have to be both as simple but also as robust as possible. This heavily revised second edition takes a practice-oriented approach with a strong emphasis on efficiency, and offers important new and updated material on; Overlapping and embedded grid methods Treatment of free surfaces Grid generation Optimal use of supercomputing hardware Optimal shape and process design Applied Computational Fluid Dynamics Techniques, 2nd edition is a vital resource for engineers, researchers and designers working on CFD, aero and hydrodynamics simulations and bioengineering. Its unique practical approach will also appeal to graduate students of fluid mechanics and aero and hydrodynamics as well as biofluidics.
Though many 'finite element' books exist, this book provides a unique focus on developing the method for three-dimensional, industrial problems. This is significant as many methods which work well for small applications fail for large scale problems, which generally: are not so well posed introduce stringent computer time conditions require robust solution techniques. Starting from sound continuum mechanics principles, derivation in this book focuses only on proven methods. Coverage of all different aspects of linear and nonlinear thermal mechanical problems in solids are described, thereby avoiding distracting the reader with extraneous solutions paths. Emphasis is put on consistent representation and includes the examination of topics which are not frequently found in other texts, such as cyclic symmetry, rigid body motion and nonlinear multiple point constraints. Advanced material formulations include anisotropic hyperelasticity, large strain multiplicative viscoplasticity and single crystal viscoplasticity. Finally, the methods described in the book are implemented in the finite element software CalculiX, which is freely available (www.calculix.de; the GNU General Public License applies). Suited to industry practitioners and academic researchers alike, The Finite Element Method for Three-Dimensional Thermomechanical Applications expertly bridges the gap between continuum mechanics and the finite element method.
Adopting a cross-disciplinary approach, the review character of this monograph sets it apart from specialized journals. The editor is advised by a first-class board of international scientists, such that the carefully selected and invited contributions represent the latest and most relevant findings.
Adopting a cross-disciplinary approach, the review character of this monograph sets it apart from specialized journals. The editor is advised by a first-class board of international scientists, such that the carefully selected and invited contributions represent the latest and most relevant findings. The resulting review enables both researchers and newcomers in life science, physics, and chemistry to access the most important results in this field, using a common language.
This work meets the need for an affordable textbook that helps in understanding numerical solutions of ODE. Carefully structured by an experienced textbook author, it provides a survey of ODE for various applications, both classical and modern, including such special applications as relativistic systems. The examples are carefully explained and compiled into an algorithm, each of which is presented independent of a specific programming language. Each chapter is rounded off with exercises.
* Explains the physical meaning of linear and nonlinear structural mechanics. * Shows how to perform nonlinear structural analysis. * Points out important nonlinear structural dynamics behaviors. * Provides ready-to-use governing equations.
This handbook provides an up-to-date survey of current research topics and applications of time series analysis methods written by leading experts in their fields. It covers recent developments in univariate as well as bivariate and multivariate time series analysis techniques ranging from physics' to life sciences' applications. Each chapter comprises both methodological aspects and applications to real world complex systems, such as the human brain or Earth's climate. Covering an exceptionally broad spectrum of topics, beginners, experts and practitioners who seek to understand the latest developments will profit from this handbook.