Медицина
Различные книги в жанре МедицинаMissing Data in Clinical Studies
Missing Data in Clinical Studies provides a comprehensive account of the problems arising when data from clinical and related studies are incomplete, and presents the reader with approaches to effectively address them. The text provides a critique of conventional and simple methods before moving on to discuss more advanced approaches. The authors focus on practical and modeling concepts, providing an extensive set of case studies to illustrate the problems described. Provides a practical guide to the analysis of clinical trials and related studies with missing data. Examines the problems caused by missing data, enabling a complete understanding of how to overcome them. Presents conventional, simple methods to tackle these problems, before addressing more advanced approaches, including sensitivity analysis, and the MAR missingness mechanism. Illustrated throughout with real-life case studies and worked examples from clinical trials. Details the use and implementation of the necessary statistical software, primarily SAS. Missing Data in Clinical Studies has been developed through a series of courses and lectures. Its practical approach will appeal to applied statisticians and biomedical researchers, in particular those in the biopharmaceutical industry, medical and public health organisations. Graduate students of biostatistics will also find much of benefit.
Statistical Meta-Analysis with Applications
An accessible introduction to performing meta-analysis across various areas of research The practice of meta-analysis allows researchers to obtain findings from various studies and compile them to verify and form one overall conclusion. Statistical Meta-Analysis with Applications presents the necessary statistical methodologies that allow readers to tackle the four main stages of meta-analysis: problem formulation, data collection, data evaluation, and data analysis and interpretation. Combining the authors' expertise on the topic with a wealth of up-to-date information, this book successfully introduces the essential statistical practices for making thorough and accurate discoveries across a wide array of diverse fields, such as business, public health, biostatistics, and environmental studies. Two main types of statistical analysis serve as the foundation of the methods and techniques: combining tests of effect size and combining estimates of effect size. Additional topics covered include: Meta-analysis regression procedures Multiple-endpoint and multiple-treatment studies The Bayesian approach to meta-analysis Publication bias Vote counting procedures Methods for combining individual tests and combining individual estimates Using meta-analysis to analyze binary and ordinal categorical data Numerous worked-out examples in each chapter provide the reader with a step-by-step understanding of the presented methods. All exercises can be computed using the R and SAS software packages, which are both available via the book's related Web site. Extensive references are also included, outlining additional sources for further study. Requiring only a working knowledge of statistics, Statistical Meta-Analysis with Applications is a valuable supplement for courses in biostatistics, business, public health, and social research at the upper-undergraduate and graduate levels. It is also an excellent reference for applied statisticians working in industry, academia, and government.
Bioequivalence Studies in Drug Development
Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities. Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects required by regulatory authorities. This text presents the required statistical methods, and with an outstanding practical emphasis, demonstrates their applications through numerous examples using real data from drug development. Includes all the necessary pharmacokinetic background information. Presents parametric and nonparametric statistical techniques. Describes adequate methods for power and sample size determination. Includes appropriate presentation of results from bioequivalence studies. Provides a practical overview of the design and analysis of bioequivalence studies. Presents the recent developments in methodology, including population and individual bioequivalence. Reviews the regulatory guidelines for such studies, and the existing global discrepancies. Discusses the designs and analyses of drug-drug and food-drug interaction studies. Bioequivalence Studies in Drug Development is written in an accessible style that makes it ideal for pharmaceutical scientists, clinical pharmacologists, and medical practitioners, as well as biometricians working in the pharmaceutical industry. It will also be of great value for professionals from regulatory bodies assessing bioequivalence studies.
Statistical Methods in Spatial Epidemiology
Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bio-terrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is updated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying this knowledge to the fundamental problems within spatial epidemiology, such as disease mapping, ecological analysis, disease clustering, bio-terrorism, space-time analysis, surveillance and infectious disease modelling. Provides a comprehensive overview of the main statistical methods used in spatial epidemiology. Updated to include a new emphasis on bio-terrorism and disease surveillance. Emphasizes the importance of space-time modelling and outlines the practical application of the method. Discusses the wide range of software available for analyzing spatial data, including WinBUGS, SaTScan and R, and features an accompanying website hosting related software. Contains numerous data sets, each representing a different approach to the analysis, and provides an insight into various modelling techniques. This text is primarily aimed at medical statisticians, researchers and practitioners from public health and epidemiology. It is also suitable for postgraduate students of statistics and epidemiology, as well professionals working in government agencies.
Introduction to Statistics for Forensic Scientists
Introduction to Statistics for Forensic Scientists is an essential introduction to the subject, gently guiding the reader through the key statistical techniques used to evaluate various types of forensic evidence. Assuming only a modest mathematical background, the book uses real-life examples from the forensic science literature and forensic case-work to illustrate relevant statistical concepts and methods. Opening with a brief overview of the history and use of statistics within forensic science, the text then goes on to introduce statistical techniques commonly used to examine data obtained during laboratory experiments. There is a strong emphasis on the evaluation of scientific observation as evidence and modern Bayesian approaches to interpreting forensic data for the courts. The analysis of key forms of evidence are discussed throughout with a particular focus on DNA, fibres and glass. An invaluable introduction to the statistical interpretation of forensic evidence; this book will be invaluable for all undergraduates taking courses in forensic science. Introduction to the key statistical techniques used in the evaluation of forensic evidence Includes end of chapter exercises to enhance student understanding Numerous examples taken from forensic science to put the subject into context
Skin Diseases of Exotic Pets
There is currently a lot of interest within veterinary medicine in both dermatology and exotics, yet, despite this interest, there is no single text available that focuses on both these key areas. This book, for the first time, provides a practical guide to dermatological problems in birds, reptiles, fish and mammals. Divided into the four groups, each section has a chapter introducing the structure and function of the skin of each group, a chapter on examination and diagnostic tests, and further chapters on species specific skin diseases and treatments. Written in a quick reference format and including almost 200 colour photographs, this book is a handy resource for veterinary practitioners, veterinary students and veterinary dermatologists alike.
Canine Sports Medicine and Rehabilitation
Canine Sports Medicine and Rehabilitation, Second Edition offers a thoroughly revised and updated new edition of this gold standard reference for all aspects of sports medicine and rehabilitation, encompassing basic science and integrated veterinary and physical therapy approaches. Presents current, state-of-the-art information on sports medicine and rehabilitation in dogs Offers perspectives from an international list of expert authors Covers all topics related to veterinary care of the canine athlete and all active dogs Includes illustrations and photographs throughout to demonstrate key concepts Provides clinical cases that set the information in context
Blackwell's Five-Minute Veterinary Consult: Laboratory Tests and Diagnostic Procedures
Blackwell’s Five-Minute Veterinary Consult: Laboratory Tests and Diagnostic Procedures: Canine and Feline is a comprehensive, one-stop reference text on diagnostic skills used daily in treating dogs and cats. Chapters cover more than 275 procedures and tests, including blood, urine, and fecal tests and radiographic, ultrasound, and endoscopic procedures. Each topic, written by an expert in the field, provides essential information on related physiology, indications, contraindications, potential complications, and client education. The uniform presentation of information, arranged alphabetically from abdominal radiographs to zinc tests, allows the reader to gain easy access to vital information, making this an ideal reference to be used in a clinical setting.
Diseases of Domestic Guinea Pigs
This book provides a comprehensive text covering all aspects of guinea pig medicine. This updated edition will be of value to veterinary surgeons and students, veterinary nurses, breeders and all those working in the animal care industry. Written in note form the book assists in the formulation of a diagnostic plan when the practitioner is faced with a sick animal. Sections on clinical signs, diagnoses and treatments, allow rapid reference in successive chapters on the reproductive, digestive, respiratory, musculoskeletal and urinary systems, the skin, head and neck, nervous system and husbandry. All the latest drug information has been included and full details of dose rates, contraindications and components of the proprietary preparations are listed in chapter 11. A new chapter has been written providing information on herbal and homeopathic remedies.
Diseases of Small Domestic Rodents
Not so long ago, hamsters, gerbils and mice were the only rodents kept as pets. Now the variety of rodents and the increasing popularity of these small creatures kept as pets has grown considerably. Since the last edition of Diseases of Small Domestic Rodents, two more rodents have been added to this book and become favourites among pet owners – the degu and the jird. As well as two new chapters on jirds and degus, this book has been fully revised and updated to reflect current developments in the treatment and knowledge of diseases in small rodents. With specific sections on anaesthesia and detailed information on drug treatments, Diseases of Small Domestic Rodents is the definitive reference book for students, breeders and practitioners alike.