Медицина
Различные книги в жанре МедицинаMetabolic Syndrome. Underlying Mechanisms and Drug Therapies
This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in-depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and clinical implications.
Genotoxic Impurities. Strategies for Identification and Control
This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and data interpretation. The second section addresses the risk posed by genotoxic impurities from outside sources and from mutagens within DNA. In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.
Versorgungsforschung in Deutschland. Stand – Perspektiven – Förderung – Standpunkte
Deutsche Forschungsgemeinschaft (DFG)
Leitfaden der DFG wie vor allem Nachwuchsforscher in diesem interdisziplinaren Gebiet in den Genuss von Fordermittel kommen.
Microbiology of Drinking Water. Production and Distribution
Microbiology of Drinking Water Production and Distribution addresses the public health aspects of drinking water treatment and distribution. It explains the different water treatment processes, such as pretreatment, coagulation, flocculation, sedimentation, filtration, disinfection, and their impacts on waterborne microbial pathogens and parasites. Drinking water quality may be degraded in water distribution systems—microorganisms form biofilms within distribution systems that allow them to flourish. Various methodologies have been proposed to assess the bacterial growth potential in water distribution systems. Microbiology of Drinking Water Production and Distribution also places drinking water quality and public health issues in context; it addresses the effect of bioterrorism on drinking water safety, particularly safeguards that are in place to protect consumers against the microbial agents involved. In addition, the text delves into research on drinking water quality in developing countries and the low-cost treatment technologies that could save lives. The text also examines the microbiological water quality of bottled water, often misunderstood by the public at large.
Drugs of Abuse. Pharmacology and Molecular Mechanisms
Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience of drug abuse. Understanding the chemistry of commonly abused drugs and their impact on brain function will provide students and researchers with a more profound understanding of the molecular basis of drug abuse and addiction. Drugs of Abuse: Pharmacology and Molecular Mechanisms opens with a brief history of drug use and abuse. Subsequent sections look at specific families of drugs, including stimulants, depressants, and hallucinogens among others, and explore how their chemical make-up interacts with brain function. The final chapter provides a brief overview of clinical substance abuse treatment. Providing a concise, accessible introductory overview of the topic, Drugs of Abuse: Pharmacology and Molecular Mechanisms will be a valuable resource for students, researchers, and others interested in how drugs interact with the brain. Introduces readers to the basic principles of neuroscience and pharmacology as related to drug use and abuse. Explores how the chemical make-up of drugs interact with the brain and can lead to addiction Includes coverage of a wide array of commonly abused families of drugs, including stimulants, depressants, hallucinogens, and others. Provides an essential introduction to the chemical and molecular underpinnings of drug use and abuse
Understanding Medical Research. The Studies That Shaped Medicine
Medical students and junior and senior doctors are frequently called upon to give research presentations, write reports, and answer exam questions on specific areas of medical research. Understanding Medical Research: The Studies That Shaped Medicine is an exciting new title that offers a unique and valuable approach to understanding historically influential studies in important areas of medicine. Featuring chapters from Sir Liam Donaldson and Sir David Weatherall, amongst others, world leading researchers identify ten primary research papers that have shaped the direction of research in their given topic, examining why they were carried out, key findings, and how they changed the field. Each chapter also contains short sections on ‘Key Questions Remaining’ which outline outstanding areas where further research is needed, and a link to ‘Key Laboratories/Clinics’ which point the reader to major research groups of international standing. Covering the seminal research in core areas of medicine, Understanding Medical Research provides an authoritative framework on each topic for medical students and healthcare professionals.
Absorption and Drug Development. Solubility, Permeability, and Charge State
Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.
Metabolic Syndrome Pathophysiology. The Role of Essential Fatty Acids
Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease. Specific interactions of essential fatty acids and polyunsaturated fatty acids in brain development and several disease groups are described. The role of inflammation in disease and how fatty acids regulate low-systemic inflammation are examined and explained. Metabolic and neurologic dynamics are presented to provide a linkage between the presence of omega-3 and omega-6 and protection against diseases and conditions such as diabetes mellitus, obesity, autoimmune diseases and hypertension.
Revisiting Cardiac Anatomy. A Computed-Tomography-Based Atlas and Reference
This new atlas represents a fresh fresh approach to cardiac anatomy, providing images of unparalleled quality, along with explanatory text, to show in vivo heart anatomy and explain the clinically relevant underlying anatomic concepts. In spite of amazing proliferation of information on the Internet and multiple websites filled with up-to-date information, there is no similarly detailed and systematic compilation of morphological imaging with CT. Organized for both systematic learning and to serve as a quick, yet detailed reference for specific clinical questions, this book is an invaluable resource for medical students and residents, cardiologists, and especially surgeons, interventionalists and electrophysiologists, who depend on ever more detailed imaging support in order to successfully perform increasingly complex coronary and noncoronary structural interventions and other procedures.