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Список книг автора Группа авторовStrategies for Organic Drug Synthesis and Design
This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.
Annual Plant Reviews, Flowering and its Manipulation
The flowering plants now dominate the terrestrial ecosystems of the planet, and there are good reasons for supposing that the flower itself has been a major contributing factor to the spread of the Angiosperms. The flowers of higher plants not only contain the organs of plant reproduction but are of fundamental importance in giving rise to fruits and seeds which constitute a major component of the human diet. This volume opens with a chapter describing a model for the evolution of the Angiosperm flower. Chapters 2 to 5 describe the core development of the flower and include floral induction, floral pattering and organ initiation, floral shape and size, and inflorescence architecture. Chapters 6 to 8 focus on more specialised aspects of floral development: monoecy, cytoplasmic male sterility and flowering in perennials. Chapters 9 and 10 address more functional aspects: flower colour and scent. The book concludes, appropriately, with a chapter on flower senescence. Applied aspects are stressed wherever appropriate, and the book is directed at researchers and professionals in plant genetics, developmental and molecular biology. The volume has been designed to complement an earlier volume in our Annual Plant Reviews series, O’Neill, S. D. and Roberts, J. A. (2002) Plant Reproduction.
Antioxidants and Reactive Oxygen Species in Plants
Reactive oxygen species (ROS) are produced during the interaction of metabolism with oxygen. As ROS have the potential to cause oxidative damage by reacting with biomolecules, research on ROS has concentrated on the oxidative damage that results from exposure to environmental stresses and on the role of ROS in defence against pathogens. However, more recently, it has become apparent that ROS also have important roles as signalling molecules. A complex network of enzymatic and small molecule antioxidants controls the concentration of ROS and repairs oxidative damage, and research is revealing the complex and subtle interplay between ROS and antioxidants in controlling plant growth, development and response to the environment. This book covers these new developments, generally focussing on molecular and biochemical details and providing a point of entry to the detailed literature. It is directed at researchers and professionals in plant molecular biology, biochemistry and cell biology, in both the academic and industrial sectors.
Probes and Tags to Study Biomolecular Function
The only resource to systematically review current experimental methods, this handy reference enables researchers to select the best solution for their experimental problems. For each method covered, the book provides step-by-step protocols, illustrated by typical research applications. After an initial section on probing the lipid bilayer, the text moves on to discuss probing proteins – including membrane proteins – and nucleic acids. The first single publication to incorporate chemical markers, fluorescent probes and genetic tags allows a well-informed comparison of different solutions for the same problem in molecular analytics.
Prediction of Protein Structures, Functions, and Interactions
The growing flood of new experimental data generated by genome sequencing has provided an impetus for the development of automated methods for predicting the functions of proteins that have been deduced by sequence analysis and lack experimental characterization. Prediction of Protein Structures, Functions and Interactions presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use. Methods of modeling of individual proteins, prediction of their interactions, and docking of complexes are put in the context of predicting gene ontology (biological process, molecular function, and cellular component) and discussed in the light of their contribution to the emerging field of systems biology. Topics covered include: first steps of protein sequence analysis and structure prediction automated prediction of protein function from sequence template-based prediction of three-dimensional protein structures: fold-recognition and comparative modelling template-free prediction of three-dimensional protein structures quality assessment of protein models prediction of molecular interactions: from small ligands to large protein complexes macromolecular docking integrating prediction of structure, function, and interactions Prediction of Protein Structures, Functions and Interactions focuses on the methods that have performed well in CASPs, and which are constantly developed and maintained, and are freely available to academic researchers either as web servers or programs for local installation. It is an essential guide to the newest, best methods for prediction of protein structure and functions, for researchers and advanced students working in structural bioinformatics, protein chemistry, structural biology and drug discovery.
From Cosmological Structures to the Milky Way
Volume 18 continues the Reviews in Modern Astronomy with twelve invited reviews and highlight contributions which were presented during the International Scientific Conference of the Astronomical Society on the topic «From Cosmological Structures to the Milky Way», held in Prague, Czech Republic, September 20 to 25, 2004. The contributions to the meeting published in this volume discuss, among other subjects, X-ray astronomy, cosmology, star formation and the Galactic Centre.
The Blackwell Guide to Theology and Popular Culture
The Blackwell Guide to Theology of Popular Culture outlines various general theories of popular culture, identifies theologians and theological concepts that are conducive to analyzing popular culture, and explores religious themes that are asserting themselves through popular movies, novels, music, television shows and advertising. A timely examination and contribution to the rapidly expanding field of theology and popular culture Locates the theological analysis of culture alongside political, sociological, economic, aesthetic and psychological analyses Surveys the work of religious and theological scholars who have turned their attention to popular culture Considers classic Christian thinkers who have wrestled with culture, such as St. Paul, Tertullian, Augustine, Schleiermacher, Tillich, and Ricoeur Proposes a method for analysing culture to discern its religious content Identifies religious themes in popular culture Uses illustrations, ranging from the fiction of Nick Hornby to Six Feet Under An appendix provides lists of films, novels, television series, consumer products, architectural works, cultural events, and corporate icons that lend themselves to theological analysis.
Essentials of Myers-Briggs Type Indicator Assessment
Quickly acquire the knowledge and skills you need to confidently administer, score, and interpret the MBTI In order to use the Myers-Briggs Type Indicator (MBTI) appropriately and effectively, professionals need an authoritative source of advice and guidance on how to administer, score, and interpret this test. Written by Naomi Quenk—who coauthored the 1998 revision of the MBTI Manual and the MBTI Step II Manual—Essentials of Myers-Briggs Type Indicator Assessment, Second Edition is that source. Like all the volumes in the Essentials of Psychological Assessment series, this book is designed to help busy practitioners, and those in training, to quickly acquire the knowledge and skills they need to make optimal use of major psychological assessment instruments. Each concise chapter features numerous callout boxes highlighting key concepts, bulleted points, and extensive illustrative material, as well as test questions that help you gauge and reinforce your grasp of the information covered. Completely revised and up to date with discussion of new versions of the MBTI, such as MBTI Step II and MBTIComplete, Essentials of Myers-Briggs Type Indicator Assessment, Second Edition provides expert assessment of the instrument's relative strengths and weaknesses, valuable advice on its clinical applications, and several illuminating case reports.
Integrating the 12 Steps into Addiction Therapy
All the resources needed to fully integrate a 12-step approach as part of your overall treatment program Millions of Americans have at some time in their lives participated in a 12-step program for treatment of a chemical or non-chemical addiction. Clinicians recognize that these grass-roots efforts have a very high cure rate. However, little has been written on how to integrate these programs into a traditional therapy setting. Integrating the 12 Steps into Addiction Therapy serves as an indispensable resource for clinicians treating addiction patients who are simultaneously enrolled in 12-step programs. This valuable text: * Contains eight lesson plans and twenty-seven assignments * Integrates in-depth discussion of 12-step programs with hands-on resources like homework assignments, treatment plan examples, and patient handouts * Will also benefit 12-step program peer counselors * Includes companion CD-ROM with fully customizable homework assignments, lesson plans, and presentations Treating addictions-whether chemical or non-chemical-can be one of the most difficult challenges faced by mental health professionals. For many people, 12-step programs have played a critical role in helping them to manage their addictive behaviors. Integrating the 12 Steps into Addiction Therapy gives psychologists, therapists, counselors, social workers, and clinicians the tools and resources they need to fully utilize these peer therapy program techniques in treating a wide variety of addictions.
Hypnosis, Dissociation and Survivors of Child Abuse
Hypnosis has not been fully appreciated in the treatment of trauma, largely due to it being implicated in the creation of false memories, which have previously led to false allegations of child abuse. This has led to a lot of misunderstandings about hypnosis. There is now a strong argument that the educated and professional use of hypnosis may be beneficial to the field of trauma, particularly in facilitating the resolution of trauma and processing of traumatic memories. This book re-introduces the importance of hypnosis in the field of trauma, with particular reference to survivors of child abuse. It covers theories of traumatic stress, theories of hypnosis and theories related to the long term effects of child abuse. As well as providing recent research in these areas, it offers practical therapy guidelines and case illustrations to assist qualified practitioners in treating their clients. The treatment described is predominately cognitive-behavioural, and uses hypnosis as an effective and powerful adjunct to this approach.