Principles of Virology. Jane Flint

viruses at virology.ws and is host of the popular science program This Week in Virology, which, together with six other science podcasts, can be found at microbe.tv.

      Glenn F. Rall is a Professor and the Chief Academic Officer at the Fox Chase Cancer Center in Philadelphia. He is an Adjunct Professor in the Microbiology and Immunology departments at the University of Pennsylvania and Thomas Jefferson, Drexel, and Temple Universities. Dr. Rall’s laboratory studies viral infections of the brain and the immune responses to those infections, with the goal of defining how viruses contribute to disease in humans. His service to the scientific community includes former membership on the Autism Speaks Scientific Advisory Board, Editor of PLoS Pathogens, Career Development Chair and Program Chair of the American Society for Virology, and membership on multiple NIH grant review panels.

Theodora Hatziioannou is a Research Associate Professor at Rockefeller University in New York. Throughout her career, Dr. Hatziioannou has worked on multiple viruses, with a particular focus on retroviruses and the molecular mechanisms that govern virus tropism and on the improvement of animal models for human disease. She is actively involved in teaching programs at the Rockefeller University and the Albert Einstein College of Medicine, is an editor of Journal of General Virology, and serves as a reviewer for multiple scientific journals and NIH grant review panels.

      Anna Marie Skalka is a Professor Emerita and former Senior Vice President for Basic Research at the Fox Chase Cancer Center in Philadelphia. Dr. Skalka’s major research interests are the molecular aspects of retrovirus biology. Dr. Skalka is internationally recognized for her contributions to the understanding of the biochemical mechanisms by which such viruses (including the AIDS virus) replicate and insert their genetic material into the host genome. Both an administrator and researcher, Dr. Skalka has been deeply involved in state, national, and international advisory groups concerned with the broader, societal implications of scientific research. She has also served on the editorial boards of peer-reviewed scientific journals and has been a member of scientific advisory boards including the National Cancer Institute Board of Scientific Counselors, the General Motors Cancer Research Foundation Awards Assembly, the Board of Governors of the American Academy of Microbiology, and the National Advisory Committee for the Pew Biomedical Scholars.

Key of Repetitive Elements

1 Foundations

        Luria’s Credo

        Viruses Defined

        Why We Study Viruses Viruses Are Everywhere Viruses Infect All Living Things Viruses Can Cause Human Disease Viruses Can Be Beneficial Viruses “R” Us Viruses Can Cross Species Boundaries Viruses Are Unique Tools To Study Biology

        Virus Prehistory Viral Infections in Antiquity The First Vaccines Microorganisms as Pathogenic Agents

        Discovery of Viruses

        The Defining Properties of Viruses The Structural Simplicity of Virus Particles The Intracellular Parasitism of Viruses

        Cataloging Animal Viruses The Classical System Classification by Genome Type: the Baltimore System

        A Common Strategy for Viral Propagation

        Perspectives

        References

        Study Questions

      LINKS FOR CHAPTER 1

       Video: Interview with Dr. Donald Henderson http://bit.ly/Virology_Henderson

       This Week in Virology (TWIV): A weekly podcast about viruses featuring informal yet informative discussions and interviews with guests about the latest topics in the field http://www.microbe.tv/twiv

       Marine viruses and insect defense http://bit.ly/Virology_Twiv301

       Giants among viruses http://bit.ly/Virology_Twiv261

       Whiter reefs, fresh breath http://www.microbe.tv/twiv/twiv-391/

       Latest update of virus classification from the ICTV https://talk.ictvonline.org/taxonomy/

       The abundant and diverse viruses of the seas http://bit.ly/Virology_3-20-09

       How many viruses on Earth? http://bit.ly/Virology_9-6-13

Thus, we cannot reject the assumption that the effect of the filtered lymph is not due to toxicity, but rather to the ability of the agent to replicate.

      F. LOEFFLER, 1898

Luria’s Credo

      “There is an intrinsic simplicity of nature and the ultimate contribution of science resides in the discovery of unifying and simplifying generalizations, rather than in the description of isolated situations—in the visualization of simple, overall patterns rather than in the analysis of patchworks.” More than half a century has passed since Salvador Luria wrote this credo in the introduction