Principles of Virology. Jane Flint

OF

      Virology

       FIFTH EDITION

       Jane Flint

      Department of Molecular Biology

      Princeton University

      Princeton, New Jersey

       Vincent R. Racaniello

      Department of Microbiology & Immunology

      Vagelos College of Physicians and Surgeons

      Columbia University

      New York, New York

       Glenn F. Rall

      Fox Chase Cancer Center

      Philadelphia, Pennsylvania

       Theodora Hatziioannou

      The Rockefeller University

      New York, New York

       Anna Marie Skalka

      Fox Chase Cancer Center

      Philadelphia, Pennsylvania

Copyright © 2020 American Society for Microbiology. All rights reserved.

      Copublication by the American Society for Microbiology and John Wiley & Sons, Inc.

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      The right of Jane Flint, Vincent R. Racaniello, Glenn F. Rall, Theodora Hatziioannou, and Anna Marie Skalka to be identified as the author(s) of this work/the editorial material in this work has been asserted in accordance with law.

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       Library of Congress Cataloging-in-Publication Data

      Names: Flint, S. Jane, author. | Racaniello, V. R. (Vincent R.), author. | Rall, Glenn F., author. | Hatziioannou, Theodora, author. | Skalka, Anna Marie, author.

      Title: Principles of virology / Jane Flint, Department of Molecular Biology, Princeton University, Princeton, New Jersey, Vincent R. Racaniello, Department of Microbiology & Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, Glenn F. Rall, Fox Chase Cancer Center, Philadelphia, Pennsylvania, Theodora Hatziioannou, The Rockefeller University, New York, New York, Anna Marie Skalka, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

      Description: Fifth edition. | Washington, DC : American Society for Microbiology [2020] ; Hoboken, NJ : Wiley, [2020] | Includes bibliographical references and index. | Contents: volume 1. Molecular biology—volume 2. Pathogenesis and control.

      Identifiers: LCCN 2020013722 (print) | LCCN 2020013723 (ebook) | ISBN 9781683670322 (set) | ISBN 9781683672845 (v. 1 ; paperback) | ISBN 9781683672852 (v. 2 ; paperback) | ISBN 9781683672821 (v. 1 ; adobe pdf) | ISBN 9781683673606 (v. 1 ; epub) | ISBN 9781683672838 (v. 2 ; adobe pdf) | ISBN 9781683673590 (v. 2 ; epub) | ISBN 9781683670339 (adobe pdf) | ISBN 9781683673583 (epub)

      Subjects: LCSH: Virology.

      Classification: LCC QR360 .P697 2020 (print) | LCC QR360 (ebook) | DDC 616.9/101—dc23

      LC record available at https://lccn.loc.gov/2020013722

      LC ebook record available at https://lccn.loc.gov/2020013723

      Illustrations and illustration concepting: Patrick Lane, ScEYEnce Studios

      Cover image: Visual Science

      Cover and interior design: Susan Brown Schmidler

We dedicate this book to the students, current and future scientists, physicians, and all those with an interest in the field of virology, for whom it was written.We kept them ever in mind.

       We also dedicate it to our families:Jonn, Gethyn, and Amy LeedhamDoris, Aidan, Devin, and NadiaEileen, Kelsey, and AbigailPaul, Stefan, and EveRudy, Jeannie, and Chris

       Oh, be wiser thou!Instructed that true knowledge leads to love.WILLIAM WORDSWORTHLines left upon a Seat in a Yew-tree1888

About the Instructor Companion Website

      This book is accompanied by a companion website:

      www.wiley.com/go/flint/pov5

      The website includes:

       PowerPoints of figures

       Author podcasts

       Study Questions and Answers

Preface

       The enduring goal of scientific endeavor, as of all human enterprise, I imagine, is to achieve an intelligible view of the universe. One of the great discoveries of modern science is that its goal cannot be achieved piecemeal, certainly not by the accumulation of facts. To understand a phenomenon is to understand a category of phenomena or it is nothing. Understanding is reached through creative acts.

      A. D. HERSHEY

       Carnegie Institution Yearbook 65

      All five editions of this textbook have been written according to the authors’ philosophy that the best approach to teaching introductory virology is by emphasizing shared principles. Studying the common steps of the viral reproductive cycle, illustrated with a set of representative viruses, and considering mechanisms by which these viruses can cause disease provides an integrated overview of the biology of these infectious agents. Such knowledge cannot be acquired by learning a collection of facts about individual