Fundamentals of Analytical Toxicology. Robin Whelpton

9 Gas Chromatography 9.1 Introduction 9.2 Instrumentation 9.3 Columns and column packings 9.4 Headspace and ‘purge and trap’ analysis 9.5 Formation of artefacts in gas chromatography 9.6 Derivatization for gas chromatography 9.7 Chiral separations 9.8 Summary References 10 Liquid Chromatography 10.1 Introduction 10.2 General considerations 10.3 Detection in liquid chromatography 10.4 Columns and column packings 10.5 Modes of liquid chromatography 10.6 Chiral separations 10.7 Derivatives for liquid chromatography 10.8 Use of liquid chromatography in analytical toxicology 10.9 Summary References 11 Supercritical Fluid Chromatography 11.1 Introduction 11.2 General considerations 11.3 Detection in supercritical fluid chromatography 11.4 Columns and column packings 11.5 Chiral separations 11.6 Toxicological and forensic applications 11.7 Summary References 12 Capillary Electrophoretic Techniques 12.1 Introduction 12.2 Theoretical aspects 12.3 Sample injection in capillary electrophoresis 12.4 Detection in capillary electrophoresis 12.5 Other capillary electrokinetic modes 12.6 Capillary electrophoretic techniques in analytical toxicology 12.7 Summary References 13 Mass Spectrometry 13.1 Introduction 13.2 Instrumentation 13.3 Gas chromatography-mass spectrometry 13.4 Liquid chromatography-mass spectrometry 13.5 Supercritical fluid chromatography-mass spectrometry 13.6 Capillary electrophoresis-mass spectrometry 13.7 Direct introduction mass spectrometry 13.8 Presentation of mass spectral data 13.9 Interpretation of mass spectra 13.10 Quantitative mass spectrometry 13.11 Mass spectrometry imaging 13.12 Summary References 14 Ion Mobility Spectrometry 14.1 Introduction 14.2 Theoretical aspects 14.3 Types of ion mobility spectrometry 14.4 Resolving power 14.5 Interfacing ion mobility spectrometry 14.6 Applications of ion mobility spectrometry in analytical toxicology 14.7 Summary References

      11  Section C: Essential Pharmacokinetics 15 Absorption, Distribution, Metabolism, and Excretion of Xenobiotics 15.1 Introduction 15.2 Movement of drugs and other xenobiotics around the body 15.3 Routes of administration 15.4 Distribution 15.5 Metabolism 15.6 Excretion 15.7 Pharmacogenetics and pharmacogenomics 15.8 Summary References 16 Pharmacokinetics 16.1 Introduction 16.2 Fundamental concepts 16.3 Absorption and elimination 16.4 Drug accumulation 16.5 Sustained-release preparations 16.6 Non-linear pharmacokinetics 16.7 Multi-compartment models 16.8 Non-compartmental methods 16.9 Factors affecting