Fundamentals of Analytical Toxicology. Robin Whelpton

      

      Table of Contents

      1  Cover

      2  Preface Notes

      3  Health and Safety

      4  Nomenclature, Symbols, and Conventions

      5  Uniform Resource Locators

      6  Amount Concentration and Mass Concentration

      7  Acknowledgements

      8  List of Abbreviations

      9  Section A: The Basics 1 Analytical Toxicology: Overview 1.1 Introduction 1.2 Modern analytical toxicology 1.3 Provision of analytical toxicology services 1.4 Applications of analytical toxicology 1.5 Summary References 2 Sample Collection, Transport, and Storage 2.1 Introduction 2.2 Clinical samples and sampling 2.3 Guidelines for sample collection for analytical toxicology 2.4 Sample transport, storage, and disposal 2.5 Common interferences 2.6 Summary References 3 Basic Laboratory Operations 3.1 Introduction 3.2 Aspects of quantitative analysis 3.3 Use of internal standards 3.4 Method comparison 3.5 Non-parametric statistics 3.6 Quality control and quality assessment 3.7 Operational considerations 3.8 Summary References 4 Aspects of Sample Preparation 4.1 Introduction 4.2 Modes of sample preparation 4.3 Plasma protein binding 4.4 Hydrolysis of conjugated metabolites 4.5 Extraction of drugs from tissues 4.6 Summary References 5 Colour Tests, and Spectrophotometric and Luminescence Techniques 5.1 Introduction 5.2 Colour tests in toxicology 5.3 Colour tests for pharmaceuticals and illicit drugs 5.4 UV/Visible spectrophotometry 5.5 Fluorescence and phosphorescence 5.6 Chemiluminescence 5.7 Infrared and Raman spectroscopy 5.8 Summary References 6 Immunoassays and Related Assays 6.1 Introduction 6.2 Basic principles of competitive binding assays 6.3 Heterogeneous immunoassays 6.4 Homogenous immunoassays 6.5 Microparticulate and turbidimetric immunoassays 6.6 Assay calibration, quality control, and quality assessment 6.7 Interferences and assay failures 6.8 Aptamer-based assays 6.9 Enzyme-based assays 6.10 Summary References

      10  Section B: Separation Science 7 Separation Science: Theoretical Aspects 7.1 General introduction 7.2 Theoretical aspects of chromatography 7.3 Measurement of analyte retention 7.4 Summary References 8 Planar Chromatography 8.1 Introduction 8.2 Qualitative thin-layer chromatography 8.3 Quantitative thin-layer chromatography 8.4 Summary References