Animal Behavior for Shelter Veterinarians and Staff. Группа авторов

neuropathy

       Orthopedic disease or arthropathy

       Osteosarcoma or other neoplasia

       Foreign body (retained pin, grass awns)

       Infection: bacterial, fungal, or parasitic

       Trauma (laceration)

       Endocrinopathies

      Pica

       Pyruvate kinase deficiency and other blood abnormalities

       Feline infectious peritonitis

       Lead poisoning

       Portosystemic shunts and other forms of liver disease

       Gastrointestinal infections (Campylobacter, Clostridium)

       Ehrlichia

       Iron‐deficiency anemia

      Psychogenic alopecia in cats

       Allergies including atopy, food‐based and hypersensitivity reactions

       Bacterial, fungal, or parasitic skin infections

       Hyperthyroidism

       Pain (from multiple causes and multiple sources)

Table 4.3 Endocrinological disorders that may lead to behavioral changes.

Conditions	Possible behavioral changes
Dogs
Hyperadrenocorticism	Polyuria, polydipsia, polyphagia, increased panting, lethargy; the signs can be easily confused with signs of anxiety
Diabetes mellitus	Polyuria, polydipsia, polyphagia; if ketoacidotic may be lethargic, depressed, and anorexic
Hypoadrenocorticism	Lethargy, anorexia
Hypothyroidism	Weight gain, lethargy, weakness and exercise intolerance
Hyperthyroidism	Polyuria, polydipsia, polyphagia, weight loss, panting, irritability, and restlessness (uncommon in dogs)
Cats
Hyperadrenocorticism	Polyuria, polydipsia, polyphagia, lethargy (dullness); excess sex hormones can also result in sexual behavior, including urine marking and intraspecific aggression; females may exhibit signs similar to those seen in estrous queens
Diabetes mellitus	Polyuria, polydipsia, polyphagia, lethargy, depression, and anorexia; diabetic neuropathy has the potential to result in discomfort when being touched or petted; may be irritable or aloof
Hypoadrenocorticism	Lethargy, anorexia
Hypothyroidism	Lethargy, mental dullness (rare in cats)
Hyperthyroidism	Polyuria, polydipsia, polyphagia, increased vocalization, irritability, and restlessness

      Hyperthyroidism is the most common endocrine disease of cats, and clinical signs reflect the overall increase in metabolism. These cats are often restless and have been described as hyperactive, polyphagic, irritable, and even aggressive. They may be more vocal, appear anxious, and urine mark.

4.7 Medical Conditions That Have Breed Tendencies and Their Associated Behavior Changes

      Diseases that have a breed tendency can be due to morphologic extremes or to an inherited condition (Rooney 2009). Examples of morphologic extremes include characteristics like dome‐shaped heads in Cavalier King Charles spaniels and corkscrew tails in bulldogs. Inherited conditions are numerous, and, at last count, 312 non‐conformation‐linked inherited disorders had been identified in the top 50 breeds of registered dogs (Summers et al. 2010).

      Selecting for breed standards and specific characteristics leads to inbreeding, reducing variation and causing an increased likelihood of concentrating genes that may have undesired effects. In addition, the incidence of these diseases in mixed‐breed and shelter dog populations has never been studied and is, therefore, unknown.

Recent research has attempted to divide diseases with breed tendencies into (i) disorders related to breed standards and (ii) inherited defects (Asher et al. 2009; Summers et al. 2010). In addition, a Genetic Illness Severity Index for Dogs (GISID) was developed to rank these conditions in terms of their impact on the welfare of the dog (Asher et al. 2009). In general, these diseases affect welfare by compromising a particular body system, often causing pain and discomfort (Yeates 2012). In addition, some of these conditions may further impact welfare by preventing normal expressions of behavior, either due to pain or associated with anatomical alterations such as ear, tail, and body conformation (Rooney 2009).

      Although the cat genome has been mapped, not as much progress has been made in identifying genetic diseases in cats. Purebred cats make up only a small portion of the overall cat population (estimates show that about 8% of cats are purebred) (American Pet Products Association 2013). Compared to the multitude of genetic tests available for dogs, there are only 20 that have been developed for cats (Slutsky et al. 2013).

      A database developed by the University of Pennsylvania allows users to search for available genetic tests in both cats and dogs (Slutsky et al. 2013):

      https://www.vet.upenn.edu/research/ academic‐departments/clinical‐sciences‐advanced‐medicine/research‐labs‐centers/ penngen/tests‐worldwide.

4.8 Behavior and/or Medical Conditions Seen in Intact versus Neutered Dogs

      4.8.1 Female Canine

      The normal reproductive cycle of the bitch consists of four phases that include proestrus, estrus, diestrus, and anestrus. Most breeds reach puberty and begin to cycle between 4 and 15 months of age. Generally, smaller breeds will come into heat sooner than larger breeds, although there is variation both within and among breeds. The domestic dog is a non‐seasonal breeder and typically has two estrus cycles per year.

      The female undergoes several changes during the estrus cycle. During the proestrus stage, the bitch’s vulva becomes swollen and firm. There may be a slight discharge that ranges in color from clear to bloody. At this stage, males will be interested in her, although she will not be interested in them. The behavior at this time mimics play, including play bows, running together, and playful chasing. The female may briefly stand for the male and then move away. The bitch may also quickly turn and growl, snap, or bite an unwelcome suitor. Generally, her ears are held back, and her tail is tucked between her legs. While tail tucking is typically associated with fear, in this instance, it is an evasive behavior preventing intromission should a male become too insistent.

      Behaviorally, estrus is the stage in which the female is receptive (allows copulatory mounting) to the male. During this time, her vulva is still enlarged, although it may be somewhat softer. The discharge may still be present and ranges from a clear to slightly serosanguinous fluid. The initial courtship behavior may still mimic play. The behavior may progress