Прочая образовательная литература
Различные книги в жанре Прочая образовательная литератураTautomerism. Concepts and Applications in Science and Technology
Reflecting the substantially increased interest in tautomerism, this book demonstrates the transformation of fundamental knowledge into novel concepts and the latest applications. Each chapter introduces the theoretical background, before reviewing and critically discussing the experimental techniques and corresponding applications. Special emphasis is placed on tautomerism under unusual conditions, such as in supramolecular solids and at surfaces, displaying the wide scope between basic research and timely applications.
Molecular Basis of Oxidative Stress. Chemistry, Mechanisms, and Disease Pathogenesis
Sets the stage for the development of better diagnostic techniques and therapeutics Featuring contributions from an international team of leading clinicians and biomedical researchers, Molecular Basis of Oxidative Stress reviews the molecular and chemical bases of oxidative stress, describing how oxidative stress can lead to the development of cancer and cardiovascular and neurodegenerative diseases. Moreover, it explains the potential role of free radicals in both the diagnosis and the development of therapeutics to treat disease. Molecular Basis of Oxidative Stress is logically organized, beginning with a comprehensive discussion of the fundamental chemistry of reactive species. Next, the book: Presents new mechanistic insights into how oxidative damage of biomolecules occurs Examines how these oxidative events effect cellular metabolism Investigates the role of oxidative stress in the pathogenesis of cancer, neurodegenerative disease, cardiovascular disease, and cystic fibrosis Explores opportunities to improve the diagnosis of disease and the design of new therapeutic agents Readers will find much novel information, including new radical chemistries and the latest discoveries of how free radicals react with biomolecules. The contributors also present recent findings that help us better understand the initiation of oxidative stress and the mechanisms leading to the pathogenesis of various diseases. Throughout the book, the use of molecular structures helps readers better understand redox chemistry. In addition, plenty of detailed figures illustrate the mechanisms of oxidative stress and disease pathogenesis. Examining everything from the basic chemistry of oxidative stress to the pathogenesis of disease, Molecular Basis of Oxidative Stress will help readers continue to explore the nature of oxidative stress and then use that knowledge to develop new approaches to prevent, detect, and treat a broad range of disease conditions.
Bioactive Natural Products. Chemistry and Biology
Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.
Additives for High Performance Applications. Chemistry and Applications
This book focuses on the chemistry of additives for high performance applications and a large number of chemical formulas are displayed in the text. The additives applications include: Analysis and separation techniques, such as high performance liquid chromatography, for example ionic liquids. Additives for electrical applications, such as capacitors, electrokinetic micropumps, lithium-ion batteries, and other battery types. Additives for solar cells for control of the active layer nanomorphology are documented as are additives for electrolyte membranes, fuel cells, such as membrane exchange humidifiers and coolant additives. Medical applications include high performance additives for the manufacture of scaffolds, controlled drug release, and nanofibers. Additives for lubricants including the deposit control, anti-wear additives, fluid loss control additives in drilling applications. Additives for concrete uses such as set retarders, curing accelerators, defoamers, permeability control additives, and corrosion protection additives.
Chirality in Supramolecular Assemblies. Causes and Consequences
Supramolecular chemistry deals with the organisation of molecules into defined assemblies using non-covalent interactions, including weaker and reversible interactions such as hydrogen bonds, and metal-ligand interactions. The aspect of stereochemistry within such chemical architectures, and in particular chirality, is of special interest as it impacts on considerations of molecular recognition, the development of functional materials, the vexed question of homochirality, nanoscale effects of interactions at interfaces, biocatalysis and enzymatic catalysis, and applications in organic synthesis. Chirality in Supramolecular Assemblies addresses many of these aspects, presenting a broad overview of this important and rapidly developing interdisciplinary field. Topics covered include: Origins of molecular and topological chirality Homochirogenesis Chirality in crystallinity Host-guest behavior Chiral influences in functional materials Chirality in network solids and coordination solids Aspects of chirality at interfaces Chirality in organic assemblies Chirality related to biocatalysis and enzymes in organic synthesis. This book is a valuable reference for researchers in the molecular sciences, materials science and biological science working with chiral supramolecular systems. It provides summaries and special insights by acknowledged international experts in the various fields.
Handbook of Reagents for Organic Synthesis. Catalytic Oxidation Reagents
The Handbook is part of the Handbook of Reagents for Organic Chemistry series, aiming at collecting articles on a particular theme that individual researchers in academia or industry can use on a daily basis. The Handbook starts with a section discussing the most important aspects of heteroarene functionalization. The introduction is followed by the alphabetical listing of the most relevant reagents drawn from the EROS database. The Editor, Andre Charette from the University of Montreal, has selected 120 reagent descriptions, many of them updated with heteroarene-specific reactions for this Handbook. Following the standard format for EROS, each article contains an overview of the synthesis and physical properties of the reagents or catalyst, conditions for its storage, and purification methods. Given the importance of heteroarenes in biology and especially in medicinal chemistry, a Handbook that focuses exclusively on heteroarene functionalization has been long overdue. This Handbook will have a broad appeal to many individuals engaged in the area of medicinal chemistry, fine chemical synthesis and industrial-scale chemistry. Key features: Builds on the success of the previously published Handbooks of Reagents for Organic Synthesis Compares the numerous new C-H functionalization reactions that have been developed in the past decade Heteroarene functionalization is widely used in the development of pharmaceuticals and other bioactive compounds Contains listings of secondary reagents for which more information is available in the online edition
Comprehensive Enantioselective Organocatalysis. Catalysts, Reactions, and Applications, 3 Volume Set
Structured in three parts this manual recollects efficient organocatalytic transformations around clear principles that meet actual standard in asymmetric synthesis. Chapters were written by acknowledged leaders of the organocatalysis field, and are presented in a concise way. Volume 1: Privileged Catalysts gives insight to readers to the continuously increasing variety of catalysts, and the relatively complex interactions that make organocatalytic reactions selective. An appendix recollects catalyst structures with the adequate cross-references. Volume 2: Activations covers the fundamental activation types (non-covalent and covalent activations) and helps understanding the importance of physical parameters, and in particular, the role of water, that influences reactivity and selectivity. Volume 3: Reactions and Applications highlights transformations by reaction types. The final part of this volume is dedicated to application in multistep synthesis and industrial applications. Considering the ever increasing interest in the organocatalysis field, the book aims addressing to a large audience: to academic, and, industrial researchers, students and teachers who are interested in synthetic organic chemistry at advanced level. This book provides non-specialists with an introduction to the topic as well as serving as a valuable source for newcomers and researchers searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry.
Energy and Global Climate Change. Bridging the Sustainable Development Divide
Energy and Global Climate Change: Bridging the Sustainable Development Divide focuses attention on two urgent global development challenges faced by the UN and its member states: access to sustainable energy for all, and global climate change. This book presents compelling evidence about an often neglected aspect of the energy-climate change-development nexus faced by millions of poor: problems caused by the use of inefficient and polluting energy sources, and the lack of access to sustainable energy services. Based on a detailed examination of major UN global climate change and sustainable development negotiated outcomes over the course of several decades, this book argues in a powerful and insightful manner that intergovernmental negotiated outcomes aimed at solving the climate change and energy access challenges have been restricted by being placed in different negotiating silos. This “siloization” or compartmentalization has resulted in separate tracks of negotiated outcomes on two inextricably linked global development challenges; and, has thereby hindered prospects for integrated action. This book points out that the existence of these two silos is especially hard to ignore in light of the urgent UN-led quest for an integrated and universal post-2015 development agenda anticipated to be anchored by new sustainable development goals on energy access and climate change. By addressing the heavy reliance on inefficient and polluting energy services which result in indoor air pollution and short lived climate pollutants that tragically impact millions of poor people, this book highlights the unique importance of integrated action on the energy-poverty-climate change nexus in the UN’s post-2015 development era.
NMR Spectroscopy. Basic Principles, Concepts and Applications in Chemistry
Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful and widely used techniques in chemical research for investigating structures and dynamics of molecules. Advanced methods can even be utilized for structure determinations of biopolymers, for example proteins or nucleic acids. NMR is also used in medicine for magnetic resonance imaging (MRI). The method is based on spectral lines of different atomic nuclei that are excited when a strong magnetic field and a radiofrequency transmitter are applied. The method is very sensitive to the features of molecular structure because also the neighboring atoms influence the signals from individual nuclei and this is important for determining the 3D-structure of molecules. This new edition of the popular classic has a clear style and a highly practical, mostly non-mathematical approach. Many examples are taken from organic and organometallic chemistry, making this book an invaluable guide to undergraduate and graduate students of organic chemistry, biochemistry, spectroscopy or physical chemistry, and to researchers using this well-established and extremely important technique. Problems and solutions are included.
Community-University Engagement: A Process for Building Democratic Communities. ASHE Higher Education Report, 40:2
As the emphasis on economic development through community-university engagement intensifies, educators and policy makers must learn to think differently about the engagement process. This is particularly true when a narrowly defined group of leaders sets the engagement agenda, and those who are traditionally underrepresented continue to be marginalized in the conversations about their own futures. Emphasizing the importance of community as a context for engagement and building strong relationships over time, Moore calls on institutional leaders to intentionally facilitate broad participation by all members of a community in discussions about how and in what direction the community will develop. This is the second issue of the 40th volume of the Josse-Bass series ASHE Higher Education Report. Each monograph is the definitive analysis of a tough higher education issue, based on thorough research of pertinent literature and institutional experiences. Topics are identified by a national survey. Noted practitioners and scholars are then commissioned to write the reports, with experts providing criical reviews of each manuscript before publication.