Genetic Disorders and the Fetus. Группа авторов

377.1 503.2 694.7 17 132.3 322.0 389.6 552.2 937.2 18 130.9 311.1 401.9 602.0 1233.7 19 129.9 301.7 414.0 652.1 1584.8 20 129.2 293.7 425.8 701.8 1986.6 21 128.9 286.9 437.2 750.4 2430.0 22 128.9 281.4 448.3 797.2 2900.5 23 129.2 277.0 459.0 841.5 3378.4 24 129.8 273.7 469.2 882.5 3839.9 25 130.8 271.4 478.9 919.5 4258.8 26 132.1 270.2 488.1 951.9 4609.3 27 133.8 270.0 496.7 979.1 4868.0 28 135.8 270.8 504.7 1000.5 5016.9 29 138.3 272.6 512.1 1015.9 5045.3 30 141.1 275.4 518.8 1024.8 4951.1 31 144.4 279.3 524.8 1027.1 4741.3 32 148.1 284.4 530.0 1022.8 4430.5 33 152.3 290.6 534.5 1012.0 4040.0 34 157.0 298.0 538.2 994.8 3594.8 35 162.3 306.8 541.1 971.6 3121.4 36 168.2 317.0 543.2 942.8 2644.7 37 174.7 328.8 544.5 909.0 2186.7 38 182.0 342.3 545.0 870.7 1764.2 39 190.0 357.7 544.7 828.7 1389.0 40 198.2 375.2 543.5 783.6 1067.1 41 207.9 395.0 541.5 736.2 800.0

      Amniotic fluid volumes are in mL.

      Source: Sandlin et al. 2014.³⁷ Reproduced with permission of Springer Business + Science Media.

Polyhydramnios occurs in 1–2 percent of all pregnancies³⁵ and is associated with fetal malformations in about 40 percent of cases.⁴⁰ Moise defined polyhydramnios in singleton or twin pregnancies as MVP >8 cm in the late second and the third trimesters, and oligohydramnios as MVP <2 cm.⁴¹ Most common are neural tube defects (NTDs) and disorders that impair deglutition or absorption of AF (esophageal and other intestinal atresias or obstructions).^{26, 40, 42, 43} Myotonic dystrophy was identified in 4 of 41 patients with “idiopathic” polyhydramnios.⁴⁴ The development of polyhydramnios in anencephaly is believed to result from impaired swallowing by the fetus⁴³ or deficient antidiuretic hormone production by the fetus.⁴⁵ Polyhydramnios also occurs in maternal diabetes mellitus and may appear, especially early in pregnancy, in monozygotic twins.⁴³ Irrespective of the cause, there seems to be a risk of recurrence for polyhydramnios of between 0.06 and 8 percent.^{42, 43}

Oligohydramnios, in contrast, is most often associated with disorders of the urinary tract that interfere with micturition, such as renal agenesis.⁴⁶ Placental insufficiency and extrauterine pregnancy also may cause oligohydramnios, as can exposure to maternal hypertension treatment