Data Analytics in Bioinformatics. Группа авторов

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      A Critical Review on the Application of Artificial Neural Network in Bioinformatics

Vrs Jhalia ¹ * and Tripti Swarnkar ²

¹ Department of Computer Science and Engineering, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, India

² Department of Computer Application, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar, India

       Abstract

      Proper diagnosis of disease requires deep analysis and classification of disease. In the last two decades the exponential increase in the biological data emerged as an opportunity for many researchers. “Bioinformatics” is the integration of biology and computer science to develop methods and software tools for understanding this large biological dataset. Analyzing the hunks of data by manual means is difficult. Here computer science plays a pivotal role for extracting the hidden patterns. Among all Artificial Intelligence (AI) techniques, Artificial Neural Network (ANN) is considered as the most efficient model in pattern recognition by an automated process. ANN is a type of data structure inspired by networks of biological neurons organized in layers, in which data set is fed to the model, model learns the features from the input and predicts the output. The performance is compared based on classification accuracy. In this chapter we will make a review by comparing the classification accuracy of the ANN model with other existing classification model to get more insights to draw hypothesis.

      Keywords: Machine learning (ML), artificial neural network (ANN), prediction model, disease classification

3.1 Introduction

      We wear smart watch to measure heart beat rate, hold smart phones that scan fingerprint and retina. All these are possible because of study and research on bioinformatics. Bioinformatics brings biological themes into computers. It is basically the integration of biology with computer science, mathematics and statistics. It analyzes the biological data such as genes, proteins, genomes, cells and deals with the computational management of ecological system, genetic engineering, medical information, drug development. This can be used for prediction, modeling, visualizing and designing.

      Bioinformatics is a technique that uses computers to build mathematical model using different bioinformatics tools to acquire, manage and visualize biological data [1]. To infer relationship between components of complex biological system it develops software tools and methods to understand and analyze clinical data and biological data. This requires collecting and interpreting large chunks of biological data so as to gain information about some biological processes. In such situation computational biology is the actual program used to manipulate the data and bioinformatics puts those data to use.

      Bioinformatics has a great significance in many areas of biology. In the sphere of genetics, it allows gene prediction, understanding the gene flow, gene sequencing, interpreting genomes and their observed mutations. For image and signal processing, bioinformatics techniques are applied in experimental molecular biology for mining useful information from large amount of raw data. In the text mining bioinformatics tools help to study and organize biological data of many biological literatures, which lead to the expansion of many biological and gene ontologies. It has a significant impact in the study of protein and gene expression and regulation. In system biology bioinformatics tools are used to analyse and catalogue the biological process and networks. It also assists to gain knowledge about the evolutionary characteristics of molecular biology for analysing, comparing and interpreting genetic and genomic data [2]. Bioinformatics helps to predict the 3D structure of different macromolecules such as RNA, DNA and proteins. It also assists in the analysis and simulation of different biomolecular interactions that are an important part of structural biology [3].

       3.1.1 Different Areas of Application of Bioinformatics

      Figure 3.1 represents different fields in which bioinformatics has a great range of application. It also describes various functions of bioinformatics in each of the field.

      Figure 3.1 Areas of research of bioinformatics [4].

       3.1.2 Bioinformatics in Real World

      Health Sector

       Rapid progression of various diseases creating more scope for gene analysis to detect and classify the disease and to improve medical diagnosis.

       Bioinformatics tools are used to study genes or proteins that are associated in the pathogen and pathogenesis of the disease.

       Today by combining the clinical data with genetic data survival risk of patients are predicted.

      Drug Development

       Bioinformatics has a visible impact in drug discovery and drug development. Acquiring deep knowledge on association of gene with disease using computational tools, new disease specific drugs are discovered and validated rapidly [4].

       Bioinformatics tools are also very powerful and effective in analysis, prediction and interpretation of clinical and preclinical findings.

       Procuring more understanding by conducting research in this field will assist to develop drugs that attack the cause not merely the symptoms.

      Molecular Medicine

       With the study of genetic mechanisms we can hunt for genes that are directly related with different diseases and resulting

       knowledge will enable better treatment, speed up development of drugs and diagnostic tools to measure a person’s vulnerability to harmful diseases.

       With the application of bioinformatics tools we can identify the molecular and genetic error associated with different disease. We can also understand the molecular structures and develop molecular interventions to correct them.

      Preventative Medicine

       Study of human genes with use of bioinformatics tools allow us to find the cause of a disease.

       Development of preventive medicine will help avert and avoid the disease before it causes a disease.

      Gene Therapy

       Gene therapy is the approach to deal with gene expression of a person. This method is used to alter the gene expression of an individual to treat, cure and prevent disease.

      Waste Clean-Up

       With the use of bioinformatics tools Bacterium like Deinococcus radiodurans is identified which help cleaning the waste [4, 5].

       These organisms are efficient in cleaning up toxic chemicals and harmful radiations of waste sites.

      Study of Climate Change

       Excessive use of fossil fuels for