Middlesex. Jeffrey Eugenides

sent Marie to the doctor. The physician checked for a hernia and found undescended testicles instead. From then on, Marie donned men’s clothes, took the name of Gottlieb, and made a fortune traveling around Europe, exhibiting himself to medical men.

      As far as the doctors are concerned, I’m even better than Gottlieb. To the extent that fetal hormones affect brain chemistry and histology, I’ve got a male brain. But I was raised as a girl. If you were going to devise an experiment to measure the relative influences of nature versus nurture, you couldn’t come up with anything better than my life. During my time at the Clinic nearly three decades ago, Dr. Luce ran me through a barrage of tests. I was given the Benton Visual Retention Test and the Bender Visual-Motor Gestalt Test. My verbal IQ was measured, and lots of other things, too. Luce even analyzed my prose style to see if I wrote in a linear, masculine way, or in a circular, feminine one.

      All I know is this: despite my androgenized brain, there’s an innate feminine circularity in the story I have to tell. In any genetic history. I’m the final clause in a periodic sentence, and that sentence begins a long time ago, in another language, and you have to read it from the beginning to get to the end, which is my arrival.

      And so now, having been born, I’m going to rewind the film, so that my pink blanket flies off, my crib scoots across the floor as my umbilical cord reattaches, and I cry out as I’m sucked back between my mother’s legs. She gets really fat again. Then back some more as a spoon stops swinging and a thermometer goes back into its velvet case. Sputnik chases its rocket trail back to the launching pad and polio stalks the land. There’s a quick shot of my father as a twenty-year-old clarinetist, playing an Artie Shaw number into the phone, and then he’s in church, age eight, being scandalized by the price of candles; and next my grandfather is untaping his first U.S. dollar bill over a cash register in 1931. Then we’re out of America completely; we’re in the middle of the ocean, the sound track sounding funny in reverse. A steamship appears, and up on deck a lifeboat is curiously rocking; but then the boat docks, stern first, and we’re up on dry land again, where the film unspools, back at the beginning …

      In the late summer of 1922, my grandmother Desdemona Stephanides wasn’t predicting births but deaths, specifically, her own. She was in her silkworm cocoonery, high on the slope of Mount Olympus in Asia Minor, when her heart, without warning, missed a beat. It was a distinct sensation: she felt her heart stop and squeeze into a ball. Then, as she stiffened, it began to race, thumping against her ribs. She let out a small, astonished cry. Her twenty thousand silkworms, sensitive to human emotion, stopped spinning cocoons. Squinting in the dim light, my grandmother looked down to see the front of her tunic visibly fluttering; and in that instant, as she recognized the insurrection inside her, Desdemona became what she’d remain for the rest of her life: a sick person imprisoned in a healthy body. Nevertheless, unable to believe in her own endurance, despite her already quieting heart, she stepped out of the cocoonery to take a last look at the world she wouldn’t be leaving for another fifty-eight years.

      The view was impressive. A thousand feet below lay the old Ottoman capital of Bursa, like a backgammon board spread out across the valley’s green felt. Red diamonds of roof tile fit into diamonds of whitewash. Here and there, the sultans’ tombs were stacked up like bright chips. Back in 1922, automobile traffic didn’t clog the streets. Ski lifts didn’t cut swaths into the mountain’s pine forests. Metallurgic and textile plants didn’t ring the city, filling the air with smog. Bursa looked—at least from a thousand feet up—pretty much as it had for the past six centuries, a holy city, necropolis of the Ottomans and center of the silk trade, its quiet, declining streets abloom with minarets and cypress trees. The tiles of the Green Mosque had turned blue with age, but that was about it. Desdemona Stephanides, however, kibitzing from afar, gazed down on the board and saw what the players had missed.

      To psychoanalyze my grandmother’s heart palpitations: they were the manifestations of grief. Her parents were dead—killed in the recent war with the Turks. The Greek Army, encouraged by the Allied Nations, had invaded western Turkey in 1919, reclaiming the ancient Greek territory in Asia Minor. After years of living apart up on the mountain, the people of Bithynios, my grandmother’s village, had emerged into the safety of the Megale Idea—the Big Idea, the dream of Greater Greece. It was now Greek troops who occupied Bursa. A Greek flag flew over the former Ottoman palace. The Turks and their leader, Mustafa Kemal, had retreated to Angora in the east. For the first time in their lives the Greeks of Asia Minor were out from under Turkish rule. No longer were the giaours (“infidel dogs”) forbidden to wear bright clothing or ride horses or use saddles. Never again, as in the last centuries, would Ottoman officials arrive in the village every year, carting off the strongest boys to serve in the Janissaries. Now, when the village men took silk to market in Bursa, they were free Greeks, in a free Greek city.

      Desdemona, however, mourning her parents, was still imprisoned by the past. And so she stood on the mountain, looking down at the emancipated city, and felt cheated by her inability to feel happy like everybody else. Years later, in her widowhood, when she’d spend a decade in bed trying with great vitality to die, she would finally agree that those two years between wars a half century earlier had been the only decent time in her life; but by then everyone she’d known would be dead and she could only tell it to the television.

      For the greater part of an hour Desdemona had been trying to ignore her foreboding by working in the cocoonery. She’d come out the back door of the house, through the sweet-smelling grape arbor, and across the terraced yard into the low, thatch-roofed hut. The acrid, larval smell inside didn’t bother her. The silkworm cocoonery was my grandmother’s own personal, reeking oasis. All around her, in a firmament, soft white silkworms clung to bundled mulberry twigs. Desdemona watched them spinning cocoons, moving their heads as though to music. As she watched, she forgot about the world outside, its changes and convulsions, its terrible new music (which is about to be sung in a moment). Instead she heard her mother, Euphrosyne Stephanides, speaking in this very cocoonery years ago, elucidating the mysteries of silkworms—“To have good silk, you have to be pure,” she used to tell her daughter. “The silkworms know everything. You can always tell what somebody is up to by the way their silk looks”—and so on, Euphrosyne giving examples—“Maria Poulos, who’s always lifting her skirt for everyone? Have you seen her cocoons? A stain for every man. You should look next time”—Desdemona only eleven or twelve and believing every word, so that now, as a young woman of twenty-one, she still couldn’t entirely disbelieve her mother’s morality tales, and examined the cocoon constellations for a sign of her own impurity (the dreams she’d been having!). She looked for other things, too, because her mother also maintained that silkworms reacted to historical atrocities. After every massacre, even in a village fifty miles away, the silkworms’ filaments turned the color of blood—“I’ve seen them bleed like the feet of Christos Himself,” Euphrosyne again, and her daughter, years later, remembering, squinting in the weak light to see if any cocoons had turned red. She pulled out a tray and shook it; she pulled out another; and it was right then that she felt her heart stop, squeeze into a ball, and begin punching her from inside. She dropped the tray, saw her tunic flutter from interior force, and understood that her heart operated on its own instructions, that she had no control over it or, indeed, over anything else.

      So my yia yia, suffering the first of her imaginary diseases, stood looking down at Bursa, as though she might spot a visible confirmation of her invisible dread. And then it came from inside the house, by means of sound: her brother, Eleutherios (“Lefty”) Stephanides, had begun to sing. In badly pronounced, meaningless English:

      “Ev’ry morning, ev’ry evening, ain’t we got fun,” Lefty sang, standing before their bedroom mirror as he did every afternoon about this time, fastening the new celluloid collar to the new white shirt, squeezing a dollop of hair pomade (smelling of limes) into his palm and rubbing it into his new Valentino haircut. And continuing: “In the meantime, in-between time, ain’t we got fun.” The lyrics meant nothing to him, either, but the melody was enough. It spoke to Lefty of jazz-age frivolity, gin cocktails, cigarette girls; it made him slick his hair back with panache … while, out in the yard, Desdemona heard the singing and reacted differently. For her,