Computation in BioInformatics. Группа авторов

9.4 Conclusion and Closing Remarks References

      14  10 DNA-RNA Barcoding and Gene Sequencing 10.1 Introduction 10.2 RNA 10.3 DNA Barcoding 10.4 Main Reasons of DNA Barcoding 10.5 Limitations/Restrictions of DNA Barcoding 10.6 RNA Barcoding 10.7 Methodology 10.8 Conclusion Abbreviations Acknowledgement References

      15  11 Bioinformatics in Cancer Detection 11.1 Introduction 11.2 The Era of Bioinformatics in Cancer 11.3 Aid in Cancer Research via NCI 11.4 Application of Big Data in Developing Precision Medicine 11.5 Historical Perspective and Development 11.6 Bioinformatics-Based Approaches in the Study of Cancer 11.7 Conclusion and Future Challenges References

      16  12 Genomic Association of Polycystic Ovarian Syndrome: Single-Nucleotide Polymorphisms and Their Role in Disease Progression 12.1 Introduction 12.2 FSHR Gene 12.3 IL-10 Gene 12.4 IRS-1 Gene 12.5 PCR Primers Used 12.6 Statistical Analysis 12.7 Conclusion References

      17  13 An Insight of Protein Structure Predictions Using Homology Modeling 13.1 Introduction 13.2 Homology Modeling Approach 13.3 Steps Involved in Homology Modeling 13.4 Tools Used for Homology Modeling Acknowledgement References

      18  14 Basic Concepts in Proteomics and Applications 14.1 Introduction 14.2 Challenges on Proteomics 14.3 Proteomics Based on Gel 14.4 Non-Gel–Based Electrophoresis Method 14.5 Chromatography 14.6 Proteomics Based on Peptides 14.7 Stable Isotopic Labeling 14.8 Data Mining and Informatics 14.9 Applications of Proteomics 14.10 Future Scope 14.11 Conclusion References

      19  15 Prospects of Covalent Approaches in Drug Discovery: An Overview 15.1 Introduction 15.2 Covalent Inhibitors Against the Biological Target 15.3 Application of Physical Chemistry Concepts in Drug Designing 15.4 Docking Methodologies—An Overview 15.5 Importance of Covalent Targets 15.6 Recent Framework on the Existing Docking Protocols 15.7 S_N2 Reactions in the Computational Approaches 15.8 Other Crucial Factors to Consider in the Covalent Docking 15.9 QM/MM Approaches 15.10 Conclusion and Remarks Acknowledgements References

      20  Index

      21  Also of Interest

      22  End User License Agreement

      Guide

      1  Cover

      2  Table of Contents

      3  Title Page

      4  Copyright