John Wiley & Sons Limited
Все книги издательства John Wiley & Sons LimitedChemical Biology. Approaches to Drug Discovery and Development to Targeting Disease
An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.
Performance Consulting. Applying Performance Improvement in Human Resource Development
Praise for Performance Consulting «You hold in your hands an outstanding portrayal of the half-century evolution of performance improvement. Rothwell and his colleagues have written the most comprehensive performance consulting book on the market. From data collection and analysis to implementing solutions, Performance Consulting provides a roadmap to guide you on the path to becoming a successful performance consultant. The roadmap includes countless signposts in the form of exercises, processes, examples, tools, and advice to ensure you reach your final destination successfully.» —Elaine Biech, president, ebb associates and author of The Business of Consulting «This book provides a wealth of resources performance consultants can use for performance analysis and solution selection. The many case studies, references, and discussion questions throughout the text make this book both practical and substantive.» —Dana and Jim Robinson, co-authors of Performance Consulting: A Practical Guide for HR and Learning Professionals «In today's economic realities, performance consulting and performance improvement are critical to organizational success. The challenge for human resource development professionals is to shift the focus to performance improvement, not just applying classic training and learning solutions. Rothwell and his team have assembled perhaps the most comprehensive reference on this important field, complete with examples, illustrations, and a description of all of the pertinent models. This will be a 'must have' reference for any person involved in human resource development and human capital development.» —Jack Phillips Ph.D., chairman, ROI Institute, author of The Value of Learning
Equilibrium and Transfer in Porous Media 3. Applications, Isothermal Transport and Coupled Transfers
A porous medium is composed of a solid matrix and its geometrical complement: the pore space. This pore space can be occupied by one or more fluids. The understanding of transport phenomena in porous media is a challenging intellectual task. This book provides a detailed analysis of the aspects required for the understanding of many experimental techniques in the field of porous media transport phenomena. It is aimed at students or engineers who may not be looking specifically to become theoreticians in porous media, but wish to integrate knowledge of porous media with their previous scientific culture, or who may have encountered them when dealing with a technological problem. While avoiding the details of the more mathematical and abstract developments of the theories of acroscopization, the author gives as accurate and rigorous an idea as possible of the methods used to establish the major laws of macroscopic behavior in porous media. He also illustrates the constitutive laws and equations by demonstrating some of their classical applications. Priority is to put forward the constitutive laws in concrete circumstances without going into technical detail. This third volume in the three-volume series focuses on the applications of isothermal transport and coupled transfers in porous media.
Tools for Signal Compression. Applications to Speech and Audio Coding
This book presents tools and algorithms required to compress/uncompress signals such as speech and music. These algorithms are largely used in mobile phones, DVD players, HDTV sets, etc. In a first rather theoretical part, this book presents the standard tools used in compression systems: scalar and vector quantization, predictive quantization, transform quantization, entropy coding. In particular we show the consistency between these different tools. The second part explains how these tools are used in the latest speech and audio coders. The third part gives Matlab programs simulating these coders.
Optical Communication with Chaotic Lasers. Applications of Nonlinear Dynamics and Synchronization
Starting with an introduction to the fundamental physics in chaotic instabilities in laser systems, this comprehensive and unified reference goes on to present the techniques and technology of synchronization of chaos in coupled lasers, as well as the many applications to lasers and optics, communications, security and information technology. Throughout, it presents the current state of knowledge, including encoding/decoding techniques, performance of chaotic communication systems, random number generation, and novel communication technologies.
Isocyanide Chemistry. Applications in Synthesis and Material Science
The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.
An Introduction to Audio Content Analysis. Applications in Signal Processing and Music Informatics
With the proliferation of digital audio distribution over digital media, audio content analysis is fast becoming a requirement for designers of intelligent signal-adaptive audio processing systems. Written by a well-known expert in the field, this book provides quick access to different analysis algorithms and allows comparison between different approaches to the same task, making it useful for newcomers to audio signal processing and industry experts alike. A review of relevant fundamentals in audio signal processing, psychoacoustics, and music theory, as well as downloadable MATLAB files are also included. Please visit the companion website: www.AudioContentAnalysis.org
Fundamentals of Reliability Engineering. Applications in Multistage Interconnection Networks
This book presents fundamentals of reliability engineering with its applications in evaluating reliability of multistage interconnection networks. In the first part of the book, it introduces the concept of reliability engineering, elements of probability theory, probability distributions, availability and data analysis. The second part of the book provides an overview of parallel/distributed computing, network design considerations, and more. The book covers a comprehensive reliability engineering methods and its practical aspects in the interconnection network systems. Students, engineers, researchers, managers will find this book as a valuable reference source.
Handbook in Monte Carlo Simulation. Applications in Financial Engineering, Risk Management, and Economics
An accessible treatment of Monte Carlo methods, techniques, and applications in the field of finance and economics Providing readers with an in-depth and comprehensive guide, the Handbook in Monte Carlo Simulation: Applications in Financial Engineering, Risk Management, and Economics presents a timely account of the applicationsof Monte Carlo methods in financial engineering and economics. Written by an international leading expert in thefield, the handbook illustrates the challenges confronting present-day financial practitioners and provides various applicationsof Monte Carlo techniques to answer these issues. The book is organized into five parts: introduction andmotivation; input analysis, modeling, and estimation; random variate and sample path generation; output analysisand variance reduction; and applications ranging from option pricing and risk management to optimization. The Handbook in Monte Carlo Simulation features: An introductory section for basic material on stochastic modeling and estimation aimed at readers who may need a summary or review of the essentials Carefully crafted examples in order to spot potential pitfalls and drawbacks of each approach An accessible treatment of advanced topics such as low-discrepancy sequences, stochastic optimization, dynamic programming, risk measures, and Markov chain Monte Carlo methods Numerous pieces of R code used to illustrate fundamental ideas in concrete terms and encourage experimentation The Handbook in Monte Carlo Simulation: Applications in Financial Engineering, Risk Management, and Economics is a complete reference for practitioners in the fields of finance, business, applied statistics, econometrics, and engineering, as well as a supplement for MBA and graduate-level courses on Monte Carlo methods and simulation.
Optics in Instruments. Applications in Biology and Medicine
Optics is a science which covers a very large domain and is experiencing indisputable growth. It has enabled the development of a considerable number of instruments, the optical component or methodology of which is often the essential part of portent systems. This book sets out show how optical physical phenomena such as lasers – the basis of instruments of measurement – are involved in the fields of biology and medicine. Optics in Instruments: Applications in Biology and Medicine details instruments and measurement systems using optical methods in the visible and near-infrared, as well as their applications in biology and medicine, through looking at confocal laser scanning microscopy, the basis of instruments performing in biological and medical analysis today, and flow cytometry, an instrument which measures at high speed the parameters of a cell passing in front of one or more laser beams. The authors also discuss optical coherence tomography (OCT), which is an optical imaging technique using non-contact infrared light, the therapeutic applications of lasers, where they are used for analysis and care, and the major contributions of plasmon propagation in the field of life sciences through instrumental developments, focusing on propagating surface plasmons (PSP) and localized plasmons (LP). Contents: 1. Confocal Laser Scanning Microscopy, Thomas Olivier and Baptiste Moine. 2. Flow Cytometry (FCM) Measurement of Cells in Suspension, Odile Sabido. 3. Optical Coherence Tomography, Claude Boccara and Arnaud Dubois. 4. Therapeutic Applications of Lasers, Geneviève Bourg-Heckly and Serge Mordon. 5. Plasmonics, Emmanuel Fort. About the Authors Jean-Pierre Goure is Emeritus Professor of optics at Jean Monnet University in Saint-Etienne, France, and was previously director of the UMR 5516 laboratory linked with CNRS. He is the author of more than 100 publications in various fields, such as spectroscopy, instrumentation, sensors, optical fiber and optical communications. He was also previously deputy director in engineering science at CNRS and a member of several scientific associations such as the French Optical Society and the European Optical Society.