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This book is geared to every student in biology, pharmacy and medicine who needs to become familiar with receptor mediated signaling. The text starts with explaining some basics in membrane biochemistry, hormone biology and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment. It goes on covering each receptor superfamily in detail including their structure and evolutionary context. The last part focusses exclusively on examples where thorough knowledge of receptors is critical: pharmaceutical research, developmental biology, neurobiology and evolutionary biology. Richly illustrated, the book is perfectly suited for all courses covering receptor based signaling, regardless whether they are part of the biology, medicine or pharmacology program.
Inorganic Syntheses
This volume of Inorganic Syntheses spans the preparations of wide range of important inorganic, organometallic and solid-state compounds. The volume is divided into 6 chapters. The first chapter contains the syntheses of some key early transition metal halide clusters and the very useful mononuclear molybdenum(III) synthon, MoCl3(THF)3. Chapter 2 covers the synthesis of a number of cyclopentadienyl compounds, including a novel route to sodium and potassium cyclopentadienide, MC5H5. Chapter 3 details synthetic procedures for a range of metal-metal bonded compounds, including several with metal-metal multiple bonds. Chapter 4 contains procedures for a range of early and late transition metal compounds, each a useful synthon for further synthetic elaboration. Chapter 5 deals with the synthesis of a number of main group compounds and ligands, while Chapter 6 covers teaching laboratory experiments.
Hydraulic Modeling
Water. Except for air, it is the most important ingredient to all life on Earth. It surrounds us every day. We are literally bathed in it, we cook our food with it, and we need a steady stream of it in our bodies every single day just to survive. But water, and the study of it, is one of the most important and unheralded branches of engineering, affecting every other aspect of engineering in almost every industry. We harness its power for energy, we inject massive blasts of it into the earth to extract oil, gas, and minerals, and we use it in nearly every single industrial application, including food processing, refining, manufacturing, and waste disposal, just to name a few. Hyraulic modeling is, essentially, the understanding and prediction of fluid flow and its applications in industrial, municipal, and environmental settings, whether in a creekbed, locked in the pores of rocks deep in the earth, or in the ocean. Mathematical models, which started out with mechanical pencils and drafting tables originally, have been increasingly relied upon over the last few decades, due to the invention, growth, and refinement of computers. Physical modeling, however, is still practiced in laboratories, and it is the intersection of physical and mathematical modeling of fluid flow that is most successful in creating models that are safer, less costly, and are better for the environment. Hydraulic Modeling introduces and explores this incredibly important science, from the most basic tenets to valuable real-world applications that are used in industry today. It is the only volume on the market to offer a thorough coverage of the subject without adding lots of useless fluff or inapplicable appendices. It is a must-have for any engineer, scientist, or student working with hydraulic modeling, as a daily reference or a textbook.
Building Procurement
As an industrial process, construction is unique in that the method of procurement of any built asset (building, infrastructure or process plant) defines many of the subsequent management processes that take place during the building phase – a very different situation to the purchase of goods and services in most other industries. The procurement process is therefore central to the success of any construction project and many of the problems which impact construction projects can be traced back to the procurement phase, so a good understanding of the methods of procurement and the influence it has on project success is essential for all those working in the industry. Much has changed in the global construction industry since publication of the first edition of Building Procurement, for example the global liquidity & banking crisis and the debt burden of many major economies. This new edition has been rewritten to take account of these significant developments, but at its core it continues to provide a critical examination and review of current procurement practices in the UK, continental Europe (including EU procurement procedures), China and the USA. It retains its original strong emphasis on the need for clients to establish achievable objectives which reflect the project business case and focuses on development of suitable strategies and management structures to meet those objectives in the current construction climate. Building Procurement will be essential reading for senior undergraduate and postgraduate students of construction management and practitioners working in all areas of construction management. Review of the first edition «…a thorough and comprehensive investigation of building procurement…» Construction Management and Economics
Clinical Arrhythmology
The second edition of Clinical Arrhythmology provides a fresh, clear, and authoritative overview that will guide readers from a solid understanding of the mechanisms behind cardiac arrhythmias – which is fundamental to their identification – to diagnosis via electrocardiograms and other tools, to specific management options for each of the arrhythmias that cardiologists and other clinicians will encounter in clinical practice. Organized in a clear, intuitive manner; introducing the reader to an understanding of the anatomical and electrophysiological bases of arrhythmias, then to a comprehensive review of how to diagnose the full range of rhythmic abnormalities, and then to a discussion of specific clinical syndromes in which arrhythmias play a part Highly illustrated chapters ensure key concepts are simpler to understand Detailed appendices provide quick reference values for diagnostic and therapeutic techniques, and pharmacotherapeutic agents, and Recommendations
Klassische Mechanik
Das Buch behandelt die klassische Punktmechanik und die Mechanik starrer Korper in den Newtonschen, Lagrangeschen und Hamiltonschen Formulierungen sowie die Schwingungs- und Wellenlehre und die relativistische Mechanik. Die wichtigsten Prinzipien der Mechanik werden nicht nur vorgestellt, sondern mit zahlreichen, uber Standardaufgaben hinausgehenden Beispielen praktisch angewendet. Damit konnen die Leserinnen und Leser die Vielfalt der Mechanik kennenlernen und die mathematischen Methoden einuben, die in fortgeschrittenen Kursen vorausgesetzt werden. Interaktive MATLAB-Applikationen und fotorealistische Animationen mechanischer Probleme veranschaulichen auch kompliziertere Sachverhalte. Aus Rezensionen zu fruheren Auflagen: 'Auch die Durchmischung des Stoffes mit anschaulichen Beispielen und der gut lesbare Text werden diese Ausgabe der Klassischen Mechanik in den Bestsellerlisten halten.' (Internationale Mathematische Nachrichten) 'Die Ausgewogenheit in Theorie und Anwendungen hilft, die klassische Mechanik als das zu erkennen, was sie wirklich ist.' (Optik) Stimmen von Hochschullehrern zu fruheren Auflagen: '… ist das Buch von einer bestechenden Didaktik. Das au?ert sich im Sprachstil, der dem Leser die Begeisterung des Autors unmittelbar mitteilt …' '… mit allergro?ter – wissenschaflicher wie padagogischer – Sorgfalt …' '… ausgewogen in Theorie und Anwendungsbeispielen …'
Semiconductor Electrochemistry
Providing both an introduction and an up-to-date survey of the entire field, this text captivates the reader with its clear style and inspiring, yet solid presentation. The significantly expanded second edition of this milestone work is supplemented by a completely new chapter on the hot topic of nanoparticles and includes the latest insights into the deposition of dye layers on semiconductor electrodes. In his monograph, the acknowledged expert Professor Memming primarily addresses physical and electrochemists, but materials scientists, physicists, and engineers dealing with semiconductor technology and its applications will also benefit greatly from the contents.
Acetylsalicylic Acid
Written by a leading expert on Aspirin-related research, this is the most comprehensive treatise on the pharmacological effects and clinical applications of one of the most successful drugs ever. The text is written with a wide audience in mind, and to be readily understandable for clinicians, pharmacists, biomedical researchers and pharmacologists alike. This second, completely revised edition contains the latest results of clinical and pharmacological research on Acetylsalicylic acid, addressing the multiple pharmacological properties of this famous drug with a balanced view on their translation into clinical practice, including prevention from cardiovascular diseases and colorectal cancer.
Space Strategy
Strategy is the art of thinking about war before it occurs. Noting that space already plays a role in all of today’s wars, Space Strategy studies how conflicts are extending into this new domain. The book defines extra-atmospheric space and focuses on its varying features and constraints. By exploring the opportunities for action provided by different strategic positions, the book analyzes the most plausible combat scenarios from, against and within space. It explains the concepts of militarization, weaponization and martialization of space and shows how space systems constitute an essential component of information literacy – the key to power in the 21st Century. Space Strategy then demonstrates why our society, having become space-dependent, must take appropriate measures to develop its spatioresilience. Finally, the author summarizes his reflections in the form of a mnemonic listing twelve principles of space strategy. Completed by educational appendices and a glossary containing one thousand entries, Space Strategy meets the needs of students, researchers or any other reader curious about expanding their knowledge of strategy.
Information Warfare
Cyberspace is one of the major bases of the economic development of industrialized societies and developing. The dependence of modern society in this technological area is also one of its vulnerabilities. Cyberspace allows new power policy and strategy, broadens the scope of the actors of the conflict by offering to both state and non-state new weapons, new ways of offensive and defensive operations. This book deals with the concept of «information war», covering its development over the last two decades and seeks to answer the following questions: is the control of the information space really possible remains or she a utopia? What power would confer such control, what are the benefits?