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This textbook provides an integral and integrated treatment of industrial-relevant problems for students of both chemistry and chemical engineering. As such, this work combines the four disciplines of chemical technology – chemistry, thermal and mechanical unit operations, chemical reaction engineering and general chemical technology – and is organized into two main parts. The first covers the fundamentals, as well as the analysis and design of industrial processes, while the second section presents 20 concrete processes, exemplifying the inherent applied nature of chemical technology. These are selected so that they all differ with respect to at least one important aspect, such as the type and design of the reactor, the chemistry involved or the separation process used. As a result, readers will recapitulate, deepen and exercise the chemical and engineering principles and their interplay, as well as being able to apply them to industrial practice. Instructive figures, rules of thumb for swift but reliable estimating of parameters, data of chemical media, and examples utilizing data from industrial processes facilitate and enhance the study process. A small general survey of selected modern trends, such as multifunctional and micro reactors, or new solvents for homogeneous catalysis, such as ionic liquids, point out to the reader that this is not a concluded discipline, but a developing field with many challenges waiting to be solved.
Asymmetric Synthesis of Non-Proteinogenic Amino Acids
Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.
Bioanorganische Chemie. Metalloproteine, Methoden und Modelle
Mit dieser Einfuhrung in die faszinierende Welt der Metalloproteine lernen Chemiker, Biochemiker und Biotechnologen Mechanismen, Methoden und Modellvorstellungen der bioanorganischen Chemie kennen. In einer Synthese aus aktuellen Arbeiten an Metalloenzymzentren und den Grundlagen der Koordinationschemie fuhren die Autoren in dieses spannende und im Wortsinne komplexe Thema ein. Der erste Teil des Buches stellt anhand ausgewahlter Metalloproteine dar, dass die Natur die koordinationschemischen Prinzipien «kennt» und in einer Weise nutzt, die vorbildhaft fur die Entwicklung synthetischer Katalysatoren sein kann. Einige der verwendeten Konzepte werden in Einschuben naher beleuchtet. Der zweite Teil vermittelt die Grundlagen der verschiedenen instrumentellen Methoden fur die Untersuchung von Metalloproteinen, von der Kristallographie uber die Vielfalt an spektroskopischen Methoden (UV, Raman, Fluoreszenz, EPR, Mo?bauer etc.) bis hin zu elektrochemischen und computerchemischen Methoden. Durch die Betonung der koordinationschemischen Grundlagen biochemischer Funktion ist dieses Lehrbuch eine wichtige Erganzung zu den Standardlehrbuchern der Biochemie und der anorganischen Chemie. Der modulare Aufbau erleichtert dabei den Einsatz fur unterschiedliche Lehrveranstaltungen und Studiengange.
Molecular Catalysts. Structure and Functional Design
Highlighting the key aspects and latest advances in the rapidly developing field of molecular catalysis, this book covers new strategies to investigate reaction mechanisms, the enhancement of the catalysts' selectivity and efficiency, as well as the rational design of well-defined molecular catalysts. The interdisciplinary author team with an excellent reputation within the community discusses experimental and theoretical studies, along with examples of improved catalysts, and their application in organic synthesis, biocatalysis, and supported organometallic catalysis. As a result, readers will gain a deeper understanding of the catalytic transformations, allowing them to adapt the knowledge to their own investigations. With its ideal combination of fundamental and applied research, this is an essential reference for researchers and graduate students both in academic institutions and in the chemical industry. With a foreword by Nobel laureate Roald Hoffmann.
Small Molecule Medicinal Chemistry. Strategies and Technologies
Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting
Insect Biodiversity. Science and Society, Volume 1
Volume One of the thoroughly revised and updated guide to the study of biodiversity in insects The second edition of Insect Biodiversity: Science and Society brings together in one comprehensive text contributions from leading scientific experts to assess the influence insects have on humankind and the earth’s fragile ecosystems. Revised and updated, this new edition includes information on the number of substantial changes to entomology and the study of biodiversity. It includes current research on insect groups, classification, regional diversity, and a wide range of concepts and developing methodologies. The authors examine why insect biodiversity matters and how the rapid evolution of insects is affecting us all. This book explores the wide variety of insect species and their evolutionary relationships. Case studies offer assessments on how insect biodiversity can help meet the needs of a rapidly expanding human population, and also examine the consequences that an increased loss of insect species will have on the world. This important text: Explores the rapidly increasing influence on systematics of genomics and next-generation sequencing Includes developments in the use of DNA barcoding in insect systematics and in the broader study of insect biodiversity, including the detection of cryptic species Discusses the advances in information science that influence the increased capability to gather, manipulate, and analyze biodiversity information Comprises scholarly contributions from leading scientists in the field Insect Biodiversity: Science and Society highlights the rapid growth of insect biodiversity research and includes an expanded treatment of the topic that addresses the major insect groups, the zoogeographic regions of biodiversity, and the scope of systematics approaches for handling biodiversity data.
Darwin's Sciences
A complete scientific biography of Darwin that takes into account the latest research findings, both published and unpublished, on the life of this remarkable man. Considered the first book to thoroughly emphasize Darwin’s research in various fields of endeavor, what he did, why he did it, and its implications for his time and ours. Rather than following a strictly chronological approach – a narrative choice that characteristically offers an ascent to On the Origin of Species (1859) with a rapid decline in interest following its publication and reception – this book stresses the diversity and full extent of Darwin’s career by providing a series of chapters centering on various intellectual topics and scientific specializations that interested Darwin throughout his life. Authored by academics with years of teaching and discussing Darwin, Darwin's Sciences is suited to any biologist who is interested in the deeper implications of Darwin's research.
Treating Depression. MCT, CBT and Third Wave Therapies
A practical and conceptual guide to treating depression using both Beckian CBT and the latest, cutting-edge third wave CBT approaches, including mindfulness and metacognitive therapy. It provides an understanding of depression and its treatment and a clear practical guidance on how to use each treatment approach. Covers CBT, metacognitive therapy, and third-wave behavioural approaches within one volume Presents the theoretical background and evidence for each approach, and describes application in a clear case study approach which clearly outlines the contrasting features of the treatments Includes separate chapter commentaries on the theory and clinical material covered Internationally renowned contributors include Arthur Nezu, David A. Clark, Robert Zettle, Keith Dobson, Ruth Baer, Adrian Wells and Robert Leahy
Advanced Equity Derivatives. Volatility and Correlation
In Advanced Equity Derivatives: Volatility and Correlation, Sébastien Bossu reviews and explains the advanced concepts used for pricing and hedging equity exotic derivatives. Designed for financial modelers, option traders and sophisticated investors, the content covers the most important theoretical and practical extensions of the Black-Scholes model. Each chapter includes numerous illustrations and a short selection of problems, covering key topics such as implied volatility surface models, pricing with implied distributions, local volatility models, volatility derivatives, correlation measures, correlation trading, local correlation models and stochastic correlation. The author has a dual professional and academic background, making Advanced Equity Derivatives: Volatility and Correlation the perfect reference for quantitative researchers and mathematically savvy finance professionals looking to acquire an in-depth understanding of equity exotic derivatives pricing and hedging.
Clinical Cases in Orofacial Pain
Expand your knowledge and put it into practice with this unique, case-based guide Clinical Cases in Orofacial Pain is a valuable resource for undergraduate dental students as well as residents working towards board certification. Individual cases cover temporomandibular joint disorders, masticatory muscle disorders, headache, neuropathic pain, dental pain, tooth wear, and dystonia. Following the popular Clinical Cases series style, cases are presented with associated academic commentary, including background information, diagnostic criteria and fundamental points that might influence the diagnosis, treatment planning or management of the case. Well-illustrated throughout, each chapter features self-assessment study questions to help foster independent learning. Clinical Cases in Orofacial Pain is an excellent primer for undergraduate dental students and an invaluable study guide for postgraduate students and residents. Dental practitioners will also want to keep this unique, case-based guide as a ready reference in their working libraries.