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Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.
Salivary Gland Pathology. Diagnosis and Management
Salivary Gland Pathology: Diagnosis and Management, Second Edition, updates the landmark text in this important discipline within oral and maxillofacial surgery, otolaryngology/head and neck surgery, and general surgery. Written by well-established clinicians, educators, and researchers in oral and maxillofacial surgery, this book brings together information on the etiology, diagnosis, and treatment of all types of salivary gland pathology. Clear and comprehensive, Salivary Gland Pathology: Diagnosis and Management offers complete explanation of all points, supported by a wealth of clinical and surgical illustrations to allow the reader to gain insight into every facet of each pathologic entity and its diagnosis and treatment. Salivary Gland Pathology: Diagnosis and Management offers comprehensive coverage of all aspects of this topic. Beginning with the embryology, anatomy and physiology of the salivary glands, the first section of the book discusses radiographic imaging, infections, cystic conditions, sialoadenitis and sialolithiasis, and systemic diseases. The second section of the book is devoted to the classification of salivary gland tumors and devotes individual chapters to the discussion of each type. Additions for this section of the second edition include molecular biology of salivary gland neoplasia, radiation therapy, and chemotherapy and targeted therapy for salivary gland malignancies. The book closes with a discussion of pediatric salivary gland pathology, traumatic injuries of the salivary glands and miscellaneous pathologic processes of the salivary glands and ducts, including a section on saliva as a diagnostic fluid. The book is intended for a very diverse audience, including academic oral and maxillofacial surgeons, otolaryngologists / head and neck surgeons, general surgeons, as well as residents in these disciplines. Private practitioners will want to place this publication on the bookshelves of their offices so as to consult the textbook when evaluating a patient with salivary gland pathology.
Multi-Step Organic Synthesis. A Guide Through Experiments
Combining theoretical knowledge of synthetic transformations, practical considerations, structural elucidation by interpretation of spectroscopic data as well as rationalization of structure-property relations, this textbook presents a series of 16 independent exercises, including detailed descriptions of experimental procedures, questions, and answers. The experimental descriptions are very helpful for guiding less experienced students towards a better understanding of practical aspects in synthetic organic chemistry, while the broad scope of the questions and answers is excellent for learning purposes. The exercises are based on published research articles, adapted for didactic purposes, and will thus inspire students by way of having to solve real-life problems in chemistry. A must-have for MSc and PhD students as well as postdocs in organic chemistry and related disciplines, and lecturers and organizers of lab courses in organic chemistry.
Deep Marine Systems. Processes, Deposits, Environments, Tectonics and Sedimentation
Deep-water (below wave base) processes, although generally hidden from view, shape the sedimentary record of more than 65% of the Earth’s surface, including large parts of ancient mountain belts. This book aims to inform advanced-level undergraduate and postgraduate students, and professional Earth scientists with interests in physical oceanography and hydrocarbon exploration and production, about many of the important physical aspects of deep-water (mainly deep-marine) systems. The authors consider transport and deposition in the deep sea, trace-fossil assemblages, and facies stacking patterns as an archive of the underlying controls on deposit architecture (e.g., seismicity, climate change, autocyclicity). Topics include modern and ancient deep-water sedimentary environments, tectonic settings, and how basinal and extra-basinal processes generate the typical characteristics of basin slopes, submarine canyons, contourite mounds and drifts, submarine fans, basin floors and abyssal plains.
Electrical Drives. Principles, Planning, Applications, Solutions
From the point of view of a user this book covers all aspects of modern electrical drives. It is aimed at both users, who wish to understand, design, use, and maintain electrical drives, as well as specialists, technicians, engineers, and students, who wish to gain a comprehensive overview of electrical drives. Jens Weidauer and Richard Messer describe the principles of electrical drives, their design, and application, through to complex automation solutions. In the process, they introduce the entire spectrum of drive solutions available and their main applications. A special aspect is the combination of multiple drives to form a drive system, as well as the integration of drives into automation solutions. In simple and clear language, and supported with many diagrams, complex relationships are described and presented in an easy-to-understand way. The authors deliberately avoid a comprehensive mathematical treatment of their subject and instead focus on a coherent description of the active principles and relationships. As a result, the reader will be in a position to understand electrical drives as a whole and to solve drive-related problems in everyday professional life.
Introduction to Petroleum Engineering
Presents key concepts and terminology for a multidisciplinary range of topics in petroleum engineering Places oil and gas production in the global energy context Introduces all of the key concepts that are needed to understand oil and gas production from exploration through abandonment Reviews fundamental terminology and concepts from geology, geophysics, petrophysics, drilling, production and reservoir engineering Includes many worked practical examples within each chapter and exercises at the end of each chapter highlight and reinforce material in the chapter Includes a solutions manual for academic adopters
Analysis of Food Toxins and Toxicants
Analysis of Food Toxins and Toxicants consists of five sections, providing up-to-date descriptions of the analytical approaches used to detect a range of food toxins. Part I reviews the recent developments in analytical technology including sample pre-treatment and food additives. Part II covers the novel analysis of microbial and plant toxins including plant pyrrolizidine alkaloids. Part III focuses on marine toxins in fish and shellfish. Part IV discusses biogenic amines and common food toxicants, such as pesticides and heavy metals. Part V summarizes quality assurance and the recent developments in regulatory limits for toxins, toxicants and allergens, including discussions on laboratory accreditation and reference materials.
Iron Oxides. From Nature to Applications
Compiling all the information available on the topic, this ready reference covers all important aspects of iron oxides. Following a preliminary overview chapter discussing iron oxide minerals along with their unique structures and properties, the text goes on to deal with the formation and transformation of iron oxides, covering geological, synthetic, and biological formation, as well as various physicochemical aspects. Subsequent chapters are devoted to characterization techniques, with a special focus on X-ray-based methods, magnetic measurements, and electron microscopy alongside such traditional methods as IR/Raman and Mossbauer spectroscopy. The final section mainly concerns exciting new applications of magnetic iron oxides, for example in medicine as microswimmers or as water filtration systems, while more conventional uses as pigments or in biology for magnetoreception illustrate the full potential. A must-read for anyone working in the field.
On Education. Conversations with Riccardo Mazzeo
What is the role of education in a world where we no longer have a clear vision of the future and where the idea of a single, universal model of humanity seems like the residue of a bygone age? What role should educators play in a world where young people find themselves faced with deep uncertainty about their future, where the prospects of securing a stable, long-term career seem increasingly remote and where intensified population movements have created more diverse communities in which different cultures find themselves living side by side, no longer bound together by the belief that the other would eventually be assimilated into ‘our' culture? Faced with the bewildering features of our liquid modern world, many young people are inclined to withdraw – in some cases into the online world of games and virtual relationships, in other cases into anorexia, depression, alcohol or even drug abuse, hoping to find shelter from a world perceived as more and more dangerous. Others launch into more violent forms of behaviour, like street gangs and the looting carried out by young people who have been excluded from the temples of consumption but are eager to participate in the ceremony. And all this happens while our politicians look on, uncomprehending and indifferent. In this short book Zygmunt Bauman – the leading social theorist of our liquid modern world, here in conversation with Riccardo Mazzeo – reflects on the predicament of young people today and on the role of education and the educator in a world where the certainties of our predecessors can no longer be taken for granted.
Standard and Super-Resolution Bioimaging Data Analysis. A Primer
A comprehensive guide to the art and science of bioimaging data acquisition, processing and analysis Standard and Super-Resolution Bioimaging Data Analysis gets newcomers to bioimage data analysis quickly up to speed on the mathematics, statistics, computing hardware and acquisition technologies required to correctly process and document data. The past quarter century has seen remarkable progress in the field of light microscopy for biomedical science, with new imaging technologies coming on the market at an almost annual basis. Most of the data generated by these systems is image-based, and there is a significant increase in the content and throughput of these imaging systems. This, in turn, has resulted in a shift in the literature on biomedical research from descriptive to highly-quantitative. Standard and Super-Resolution Bioimaging Data Analysis satisfies the demand among students and research scientists for introductory guides to the tools for parsing and processing image data. Extremely well illustrated and including numerous examples, it clearly and accessibly explains what image data is and how to process and document it, as well as the current resources and standards in the field. A comprehensive guide to the tools for parsing and processing image data and the resources and industry standards for the biological and biomedical sciences Takes a practical approach to image analysis to assist scientists in ensuring scientific data are robust and reliable Covers fundamental principles in such a way as to give beginners a sound scientific base upon which to build Ideally suited for advanced students having only limited knowledge of the mathematics, statistics and computing required for image data analysis An entry-level text written for students and practitioners in the bioscience community, Standard and Super-Resolution Bioimaging Data Analysis de-mythologises the vast array of image analysis modalities which have come online over the past decade while schooling beginners in bioimaging principles, mathematics, technologies and standards.