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The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.
Analytical Characterization of Biotherapeutics
The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.
Microfluidics for Advanced Functional Polymeric Materials
A comprehensive and systematic treatment of our current understanding of the microfluidic technique and its advantages in the controllable fabrication of advanced functional polymeric materials. Introducing and summarizing recent advances and achievements in the field, the authors cover the design and fabrication of microfluidic devices, the fundamentals and strategies for controllable microfluidic generation of multiphase liquid systems, and the use of these liquid systems with an elaborate combination of their structures and compositions for generating novel polymer materials, such as microcapsules, microfibers, valves, and membranes. Clear diagrams and illustrations throughout the text make the relevant theory and technologies more readily accessible. The result is a specialist reference for materials scientists, organic, polymer and physical chemists, and chemical engineers.
Kinematic Differential Geometry and Saddle Synthesis of Linkages
With a pioneering methodology, the book covers the fundamental aspects of kinematic analysis and synthesis of linkage, and provides a theoretical foundation for engineers and researchers in mechanisms design. • The first book to propose a complete curvature theory for planar, spherical and spatial motion • Treatment of the synthesis of linkages with a novel approach • Well-structured format with chapters introducing clearly distinguishable concepts following in a logical sequence dealing with planar, spherical and spatial motion • Presents a pioneering methodology by a recognized expert in the field and brought up to date with the latest research and findings • Fundamental theory and application examples are supplied fully illustrated throughout
Successful Drug Discovery, Volume 2
Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. 11 selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section of the current drug development efforts. Backed by copious data and chemical information, the insight and experience of the contributors makes this one of the most useful training manuals that a junior medicinal chemist can hope to find and has won the support and endorsement of IUPAC.
SAS Essentials. Mastering SAS for Data Analytics
A step-by-step introduction to using SAS® statistical software as a foundational approach to data analysis and interpretation Presenting a straightforward introduction from the ground up, SAS® Essentials: Mastering SAS for Data Analytics, Second Edition illustrates SAS using hands-on learning techniques and numerous real-world examples. Keeping different experience levels in mind, the highly-qualified author team has developed the book over 20 years of teaching introductory SAS courses. Divided into two sections, the first part of the book provides an introduction to data manipulation, statistical techniques, and the SAS programming language. The second section is designed to introduce users to statistical analysis using SAS Procedures. Featuring self-contained chapters to enhance the learning process, the Second Edition also includes: Programming approaches for the most up-to-date version of the SAS platform including information on how to use the SAS University Edition Discussions to illustrate the concepts and highlight key fundamental computational skills that are utilized by business, government, and organizations alike New chapters on reporting results in tables and factor analysis Additional information on the DATA step for data management with an emphasis on importing data from other sources, combining data sets, and data cleaning Updated ANOVA and regression examples as well as other data analysis techniques A companion website with the discussed data sets, additional code, and related PowerPoint® slides SAS Essentials: Mastering SAS for Data Analytics, Second Edition is an ideal textbook for upper-undergraduate and graduate-level courses in statistics, data analytics, applied SAS programming, and statistical computer applications as well as an excellent supplement for statistical methodology courses. The book is an appropriate reference for researchers and academicians who require a basic introduction to SAS for statistical analysis and for preparation for the Basic SAS Certification Exam.
Biomechanics of Hard Tissues. Modeling, Testing, and Materials
This monograph assembles expert knowledge on the latest biomechanical modeling and testing of hard tissues, coupled with a concise introduction to the structural and physical properties of bone and cartilage. A strong focus lies on the current advances in understanding bone structure and function from a materials science perspective, providing practical knowledge on how to model, simulate and predict the mechanical behavior of bone. The book presents directly applicable methods for designing and testing the performance of artificial bones and joint replacements, while addressing innovative and safe approaches to stimulated bone regeneration essential for clinical researchers.
Training and Coaching the Paralympic Athlete
Part of the esteemed IOC Handbook of Sports Medicine and Science series, this new volume on Training and Coaching the Paralympic Athlete will be athlete-centred with each chapter written for the practical use of medical doctors and allied health personnel. The chapters also consider the role of medical science in the athlete’s sporting career and summarize current international scientific Paralympic literature. Provides a concise, authoritative overview of the science, medicine and psycho-social aspects of training and coaching disabled and Paralympic athletes Offers guidance on medical aspects unique to the training and coaching of Paralympic athletes Endorsed by both the International Olympic Committee (IOC) and the International Paralympic Committee (IPC) Written and edited by global thought leaders in sports medicine
Essentials of Energy Technology. Sources, Transport, Storage, Conservation
An in-depth understanding of energy technology, sources, conversion, storage, transport and conservation is crucial for developing a sustainable and economically viable energy infrastructure. This need, for example, is addressed in university courses with a special focus on the energy mix of renewable and depletable energy resources. Energy makes our lives comfortable, and the existence of amenities such as heaters, cars, warm water, household appliances and electrical light is characteristic for a developed economy. Supplying the industrial or individual energy consumer with energy 24 hours a day is a non-trivial challenge, especially in times where the energy is coming from very diverse resources such as oil, gas, nuclear fuels, wind, sun, or waves. This book gives physics, chemistry, engineering, and materials science students insights in the basics of energy and energy technology. It was developed along a successful course for advanced bachelor or graduate students and is written in a didactic style. The problems and solutions at the end of each chapter are ideal for exams and make self-study easy. Topics covered include energy from fossil and nuclear fuels, renewable sources, energy transport, storage, and conservation.
Pumping Machinery Theory and Practice
Pumping Machinery Theory and Practice comprehensively covers the theoretical foundation and applications of pumping machinery. Key features: Covers characteristics of centrifugal pumps, axial flow pumps and displacement pumps Considers pumping machinery performance and operational-type problems Covers advanced topics in pumping machinery including multiphase flow principles, and two and three-phase flow pumping systems Covers different methods of flow rate control and relevance to machine efficiency and energy consumption Covers different methods of flow rate control and relevance to machine efficiency and energy consumption