Прочая образовательная литература
Различные книги в жанре Прочая образовательная литератураDeep Eutectic Solvents
A useful guide to the fundamentals and applications of deep eutectic solvents Deep Eutectic Solvents contains a comprehensive review of the use of deep eutectic solvents (DESs) as an environmentally benign alternative reaction media for chemical transformations and processes. The contributors cover a range of topics including synthesis, structure, properties, toxicity and biodegradability of DESs. The book also explores myriad applications in various disciplines, such as organic synthesis and (bio)catalysis, electrochemistry, extraction, analytical chemistry, polymerizations, (nano)materials preparation, biomass processing, and gas adsorption. The book is aimed at organic chemists, catalytic chemists, pharmaceutical chemists, biochemists, electrochemists, and others involved in the design of eco-friendly reactions and processes. This important book: -Explores the promise of DESs as an environmentally benign alternative to hazardous organic solvents -Covers the synthesis, structure, properties (incl. toxicity) as well as a wide range of applications -Offers a springboard for stimulating critical discussion and encouraging further advances in the field Deep Eutectic Solvents is an interdisciplinary resource for researchers in academia and industry interested in the many uses of DESs as an environmentally benign alternative reaction media.
Innovative Dosage Forms
Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.
Noble Metal-Based Nanocomposites
Provides a systematic and coherent picture of the solution-based methods for the preparation of noble metal-based composite nanomaterials, their characterization, and potential applications in electrocatalysis Within the last decade, the development of wet-chemistry methods has led to the blossom of research in composite nanomaterials. However, the design and synthesis of composite nanomaterials with controlled properties remains a significant challenge. This book summarizes the solution-based methods for the preparation of noble metal-based composite nanomaterials. It examines their characterization, as well as their use in electrocatalysis. It also discusses the intrinsic relationship between the catalytic properties and the physical /chemical effects in the composite materials, and offers some perspectives for the future development of metal-based composite nanomaterials. In addition, the book not only provides a systematic and coherent picture of this field, but also inspires rethinking of the current processing technologies. Noble Metal-Based Nanocomposites: Preparation and Applications offers in-depth chapter coverage of ethanol-mediated phase transfer of metal ions and nanoparticles. It presents the full range of nanocomposites consisting of chalcogenide semiconductors and gold, silver sulfide, or other noble metals. It also examines core-shell structured cadmium selenide-platinum nanocomposites; Pt-containing Ag2S-noble metal nanocomposites for direct methanol fuel cells operated at high fuel concentrations; and nanocomposites consisting of metal oxides and noble metals. In addition, the book looks at scientific issues derived from noble metal-based nanocomposites. -Covers all of the preparations of noble metal-based nanocomposites and their numerous applications -Highlights some of the recent breakthroughs in the design, engineering, and applications of noble metal-based nanocomposites -Appeals to a wide range audience, especially researchers in the areas of catalysis, chemistry, chemical engineering, materials synthesis and characterization, and fuel cell Noble Metal-Based Nanocomposites: Preparation and Applications is an excellent book for inorganic chemists, materials scientists, catalytic chemists, chemical engineers, and those interested in the subject.
Introduction to Reticular Chemistry
A concise introduction to the chemistry and design principles behind important metal-organic frameworks and related porous materials Reticular chemistry has been applied to synthesize new classes of porous materials that are successfully used for myraid applications in areas such as gas separation, catalysis, energy, and electronics. Introduction to Reticular Chemistry gives an unique overview of the principles of the chemistry behind metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and zeolitic imidazolate frameworks (ZIFs). Written by one of the pioneers in the field, this book covers all important aspects of reticular chemistry, including design and synthesis, properties and characterization, as well as current and future applications Designed to be an accessible resource, the book is written in an easy-to-understand style. It includes an extensive bibliography, and offers figures and videos of crystal structures that are available as an electronic supplement. Introduction to Reticular Chemistry: -Describes the underlying principles and design elements for the synthesis of important metal-organic frameworks (MOFs) and related materials -Discusses both real-life and future applications in various fields, such as clean energy and water adsorption -Offers all graphic material on a companion website -Provides first-hand knowledge by Omar Yaghi, one of the pioneers in the field, and his team. Aimed at graduate students in chemistry, structural chemists, inorganic chemists, organic chemists, catalytic chemists, and others, Introduction to Reticular Chemistry is a groundbreaking book that explores the chemistry principles and applications of MOFs, COFs, and ZIFs.
Der Gradient in der HPLC für Anwender
Erstmalig werden in einem Buch alle Aspekte der HPLC-Gradientenelution in den unterschiedlichen Trennmodi umfassend behandelt. Der Anwender findet konkrete Hinweise zur Optimierung von klassischen Lösungsmittelgradienten für RP- und LC-MS-Trennungen neben wertvollen Hinweisen zum Einsatz von Salz-, pH-Wert- und Temperaturgradienten – praxisnah und mit zahlreichen Beispielen. Teil 1 Aspekte der Gradienten-Optimierung in der RP-Chromatographie Apparative Einflüsse auf die Qualität von Gradienten-Methoden und deren Übertragung zwischen unterschiedlichen Geräten Optimierung einer Reversed Phase Gradiententrennung mit EXCEL Teil 2 Die Gradientelution ionischer Verbindungen Der Gradient in der Biochromatographie Spezifika der Gradientenelution in der HILIC Spezifika der Gradientenelution in der SFC Der Gradient in LC-MS-Messungen
Gradient HPLC for Practitioners
This practical guide for analytical scientists explains the use of gradients in liquid chromatography. The fundamentals of gradient separations, as well as the most common application scenarios are addressed, from LC-MS coupling to biochromatography to the separation of ionic substances. Throughout, this handy volume provides detailed hands-on information for practitioners, enabling them to use gradient separation methods reliably and efficiently.
Faszinierende chemische Experimente
Chemie ist überall, man muss nur danach suchen! Mit erstaunlich einfachen Experimenten lassen sich viele faszinierende Beobachtungen über die chemische Zusammensetzung unserer Welt machen. Die Untersuchungsobjekte liegen buchstäblich auf der Straße. Von der Münze in der Hosentasche bis zur Blume am Wegesrand, vom Mineralwasser im Glas bis zum Duschgel im Badezimmer, von der Büroklammer in der Schublade bis zur eigenen Schuhsohle – alles kann und darf auf seine chemischen Bestandteile hin untersucht werden. Die beschriebenen Musterexperimente lassen dabei viel Raum für eigene Versuche und Entdeckungen. Ganz nebenbei erfährt der Leser auch noch allerlei Wissenswertes über die Herkunft und Herstellung zahlreicher Waren und Produkte, mit denen wir tagtäglich zu tun haben. Für die beschriebenen mehr als 150 Versuche und Versuchsreihen ist nur eine minimale Startausrüstung erforderlich, die in jedem mittelgroßen Chemiekasten enthalten ist. Die weiteren Reagenzien und Indikatoren werden nach den im Buch enthaltenen Vorschriften selbst hergestellt. Ein echtes Mitmach-Buch und eine Fundgrube für alle, die gerne experimentieren.
Industrial Enzyme Applications
This reference is a «must-read»: It explains how an effective and economically viable enzymatic process in industry is developed and presents numerous successful examples which underline the efficiency of biocatalysis.
Compendium of Biomedical Instrumentation
The field of medical instrumentation is inter-disciplinary, having interest groups both in medical and engineering professions. The number of professionals associated directly with the medical instrumentation field is increasing rapidly due to intensive penetration of medical instruments in the health care sector. In addition, the necessity and desire to know about how instruments work is increasingly apparent. Most dictionaries/encyclopedias do not illustrate properly the details of the bio-medical instruments which can add to the knowledge base of the person on those instruments. Often, the technical terms are not covered in the dictionaries. Unless there is a seamless integration of the physiological bases and engineering principles underlying the working of a wide variety of medical instruments in a publication, the curiosity of the reader will not be satisfied. The purpose of this book is to provide an essential reference which can be used both by the engineering as well as medical communities to understand the technology and applications of a wide range of medical instruments. The book is so designed that each medical instrument/ technology will be assigned one or two pages, and approximately 450 medical instruments are referenced in this edition.
Cell Culture Engineering
Offers a comprehensive overview of cell culture engineering, providing insight into cell engineering, systems biology approaches and processing technology In Cell Culture Engineering: Recombinant Protein Production, editors Gyun Min Lee and Helene Faustrup Kildegaard assemble top class authors to present expert coverage of topics such as: cell line development for therapeutic protein production; development of a transient gene expression upstream platform; and CHO synthetic biology. They provide readers with everything they need to know about enhancing product and bioprocess attributes using genome-scale models of CHO metabolism; omics data and mammalian systems biotechnology; perfusion culture; and much more. This all-new, up-to-date reference covers all of the important aspects of cell culture engineering, including cell engineering, system biology approaches, and processing technology. It describes the challenges in cell line development and cell engineering, e. g. via gene editing tools like CRISPR/Cas9 and with the aim to engineer glycosylation patterns. Furthermore, it gives an overview about synthetic biology approaches applied to cell culture engineering and elaborates the use of CHO cells as common cell line for protein production. In addition, the book discusses the most important aspects of production processes, including cell culture media, batch, fed-batch, and perfusion processes as well as process analytical technology, quality by design, and scale down models. -Covers key elements of cell culture engineering applied to the production of recombinant proteins for therapeutic use -Focuses on mammalian and animal cells to help highlight synthetic and systems biology approaches to cell culture engineering, exemplified by the widely used CHO cell line -Part of the renowned «Advanced Biotechnology» book series Cell Culture Engineering: Recombinant Protein Production will appeal to biotechnologists, bioengineers, life scientists, chemical engineers, and PhD students in the life sciences.