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    Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis Vol. 1

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    The field of N-heterocyclic carbenes, whether in transition-metal catalysis or organocatalysis, is rapidly evolving towards applications, but is also still very active on the catalyst development front. Significant advances have been made over the past two decades and the development of these reactions has dramatically improved the efficiency of organic synthesis. N-Heterocyclic carbene based catalysts are now widely applied in the area of synthesis of both natural products and therapeutic agents. Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis presents the most commonly used and significant metal- or non-metal-catalyzed reactions for modern organic synthesis. The basic principles and current state-of-the-art of the methods are covered. Scope, limitations, and mechanism of these reactions are discussed and key experimental procedures are included. Typical examples of target synthesis are often provided to show the utility and inspire further applications.

    Endoscopic Spine Surgery

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    Endoscopic technology has advanced to the point where practitioners can now access, visualize, and treat spine pathologies previously only accessible through open surgical approaches. Endoscopic Spine Surgery 2nd Edition provides a comprehensive background on endoscopic spine surgery and covers an unparalleled number of minimally invasive spine procedures that have revolutionized the spine treatment paradigm. Readers will greatly benefit from many years of expertise and wisdom shared by master spine surgeons Daniel Kim, Gun Choi, Sang-Ho Lee, and Richard Fessler, and their expert contributors. Due to the narrow endoscopic view, subtle microanatomical differences in the lumbar, thoracic, and cervical regions are not always easy to visually discern. To address this challenge, the book contains detailed procedural descriptions and images mirroring endoscopic views spine surgeons encounter in the OR. Organized anatomically, 53 chapters guide readers systematically through lumbar, thoracic, cervical, and craniocervical junction procedures for pathologies ranging from low back pain and deformities to tumors, lesions, infections, and trauma. Key Features More than 1000 high quality images including color procedural photographs and medical illustrations provide in-depth visual understanding.Spinal pathologies and procedures delineated in 75 videos accessible via the Media Center – from case studies to step-by-step technique tutorials.Covers the full spectrum of spine endoscopy including percutaneous approaches, microdiscectomy, laminectomy, discectomy foraminotomy, hemilaminectomy, thoracic decompressions, fusion, fixation, and thoracoscopic procedures.The use of state-of-the-art technology such as ultrasonic bone dissectors, endoscopic radiofrequency denervation, the video telescope operating monitor (VITOM), minimally invasive tubular retractors, and 3D stereo-tubular endoscopic systems.Neurosurgical and orthopaedic residents, spine fellows, and seasoned spine surgeons will all greatly benefit from the significant knowledge and insights revealed in this remarkable multimedia resource. This book may also be of interest to neurosurgical and orthopaedic nurses, physical therapists, chiropractors, and medical device professionals.

    Aphasia and Related Neurogenic Language Disorders

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    Rapid advances in neural imaging, particularly in regard to neural plasticity and brain changes, have resulted in an evolving neurorehabilitation paradigm for aphasia and related language disorders. Aphasia and Related Neurogenic Language Disorders has been adopted worldwide as a text for aphasia courses. This new 5th edition by Leonard LaPointe and Julie Stierwalt encompasses state-of-the-art concepts and approaches from an impressive cadre of experts who work in research labs, classrooms, clinics, and hospitals-including the world-renowned Mayo Clinic. As in previous editions, this book embraces a humanistic approach to treatment, addressing multicultural and multilinguistic considerations and social model interventions. The text encompasses a full continuum of cognitive-language disorder management-from everyday practicalities, assessment, and treatment to disorder-specific cases with evidence-based data. Additions to the 5th edition include chapters on pragmatics and discourse, telepractice, digital and electronic advances, funding and reimbursement, and comprehension, syntax, and linguistic based disorders. Key Features: A new chapter on neuroanatomical basics features exquisite illustrationsAn in-depth look at neurogenic communication disorders from Mayo Clinic provides firsthand insights on treating patients in an acute care hospital settingDiscussion and test questions, case studies, and clinical pearls offer invaluable didactic guidanceA chapter on expanded traumatic brain injury covers blast injuries and multisystem injuriesThis is the most comprehensive yet concise resource on aphasia and related disorders available today. New legions of speech language pathology students, residents, course directors, and practitioners will discover a remarkable guide on the treatment of communication disorders.

    Spinal Instrumentation

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    In the last two decades, spine instrumentation and surgery have undergone many improvements. The second edition benefits from contributions by renowned orthopaedic surgeons and neurosurgeons who helped create and refine the systems described in the book, and devoted their careers to educating next generations of spine surgeons. Advancements in instrumentation – plates, cages, rods, screws, disc replacements, spacers, and fusion devices – have led to improved outcomes for patients. The spinal device field has grown exponentially, and surgeons are faced with an increasingly diverse choice of instrumentation options. While the first edition categorized available systems, the new edition is focused on helping clinicians avoid complications and quickly recognize and manage complications when they do occur. Key Features A concise yet comprehensive reference that educates clinicians on the causes, recognition, and avoidance of instrumentation complicationsOrganized by anatomical region and condition, the visualization of relevant anatomical landmarks is discussed in context with safe use of spinal instrumentationNow four-color, with more than 230 new and original illustrationsEasy-to-digest text helps translate classroom knowledge into clinical applicationThis up-to-date book will help orthopaedic surgeons and neurosurgeons learn how to utilize spinal devices more efficaciously and safely. The text is also an excellent reference for radiologists, spine fellows and residents, and physician extenders who are interested in attaining knowledge and experience in spinal instrumentation.

    Cutaneous Malignancies

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    The treatment of skin cancer has become an increasingly multispecialty practice. Ongoing surgical and postsurgical advances and emergent factors that predispose patients to these tumors have changed the treatment paradigm. Having a keen understanding of diagnostic, surgical, and nonsurgical treatment options is key to identifying, treating, or referring patients with potential cutaneous malignancies. While Brian R. Gastman's Cutaneous Malignancies: A Surgical Perspective is the first of its kind to emphasize surgical management of skin cancer, several sections are devoted to systemic nonsurgical therapies affecting patient care and surgical intervention. Topics encompassed include prevention, diagnosis, medication management, appropriate margin size, reconstruction methods, and the importance of stellar dermatopathology. Key Highlights The role of Mohs micrographic surgery and radiation in skin cancer treatmentTreatment approaches for the two most common forms of skin cancer respectively, basal cell carcinoma and squamous cell carcinomaSurgical treatment of cutaneous malignant melanoma and other high-risk malignanciesClinical insights on completion lymphadenectomy and sentinel node biopsy for melanoma, two topics rarely addressed in context with skin cancerDiagnosis and treatment of rare malignancies including Merkel cell carcinoma, dermatofibrosarcoma protuberans, cutaneous angiosarcoma, and cutaneous leiomyosarcomaMore than 400 high-quality illustrations further delineate surgical modalitiesEdited by an esteemed dual board certified plastic surgeon and otolaryngologist, this definitive book is the most complete guide to surgical management of skin cancer. It is essential reading for plastic surgeons, dermatologists, otolaryngologists, and all clinicians who treat or refer patients with suspected skin cancer.

    Rhoton's Atlas of Head, Neck, and Brain

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    Masterful 2D and 3D head, neck, and brain dissections provide unsurpassed insights into head, neck, and brain anatomy An internationally renowned and beloved author, educator, brain anatomist, and neurosurgeon, Professor Albert Rhoton has a special place in medical history. He was revered by students and colleagues and is regarded as one of the fathers of modern microscopic neurosurgery. A driving principle in his anatomy lab was the simple phrase, «Every Second.» This was embraced in his philosophy that every second of every day, a patient's life was improved by a surgeon assisted by the anatomic knowledge his lab helped elucidate and distribute. Rhoton's Atlas of Head, Neck, and Brain is the visually exquisite crowning achievement of Dr. Rhoton's brilliant career and unwavering dedication to the intertwined pursuits of surgical anatomy and neurosurgery. The atlas reflects the unparalleled contributions Dr. Rhoton made to the contemporary understanding of neurosurgical anatomy. Dr. Peris-Celda, with the collaboration of an impressive cadre of international multidisciplinary experts, worked closely under Dr. Rhoton's tutelage on this project. This book is the culmination of 5 years of work and experience gleaned from more than 40 years of surgical anatomy research and exquisite dissection techniques performed in Dr. Rhoton's laboratory. Special Features Each anatomic dissection meticulously labeled with English and Latin descriptors for easy cross referencing with other resources.Multiple views of the most complex regions of the head, neck, and brain provide a deeper understanding of anatomy.More than 600 anatomical images systematically organized in four major sections: Osteology of the Head and Neck; Face and Neck; Ear, Nose, Pharynx, Larynx, and Orbit; and Neuroanatomy and Cranial Base.Superb 2D images presented in a large printed format to optimize the viewing experience.3D digital images fully realize the beauty of the dissections and enhance the learning process.Specimens injected with colored silicone provide better visualization of arteries and veins.Breathtakingly stunning, this atlas is certain to be a treasured reference for medical students, residents, and clinicians specializing in neurosurgery, facial plastic surgery, otolaryngology, maxillofacial surgery, and craniofacial surgery for many years to come.

    Radcases Musculoskeletal Radiology

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    Glenn Garcia's Musculoskeletal Radiology Second Edition prepares you to diagnose the full range of bone, ligament, muscle, and joint pathology and is ideal for exam preparation. Included in this book are 100 cases of musculoskeletal disorders, illustrated with clear, high-quality images and now with questions and answers for review. For maximum ease of self-assessment, each case begins with the clinical presentation on the right-hand page; study that and then turn the page for imaging findings, differential diagnoses with the definitive diagnosis, essential facts, pearls and pitfalls, and more. Key Highlights 547 high-resolution images guide the reader through the casesA variety of uncommon and common presentations covering everything from rheumatoid arthritis to fibrodysplasia ossificans progressivaExamples of critical cases that must be diagnosed immediately – such as septic arthritis – to avert potential disaster in daily practice and on examsFrequently encountered musculoskeletal imaging artifacts with physics-based explanations

    Science of Synthesis: Metal-Catalyzed Cyclization Reactions Vol. 1

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    Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. «Science of Synthesis: Metal-Catalyzed Cyclization Reactions» presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 1 covers intramolecular coupling reactions (including Heck reactions), intramolecular allylations, and cyclopropane and cyclopropene ring openings. Also included are cyclization reactions of alkenes, alkynes, and allenes, cycloisomerizations, and intramolecular C-N and C-O bond formation.

    Science of Synthesis: Metal-Catalyzed Cyclization Reactions Vol. 2

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    Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. «Science of Synthesis: Metal-Catalyzed Cyclization Reactions» presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.

    Surgical Wound Healing and Management

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    Surgical Wound Healing and Management, Second Edition explores the critical role of surgery in wound bed preparation and management, and provides a sound knowledge of wound mechanisms, physiology, and metabolic control. Founded on the expertise of internationally recognized authorities, this source illustrates the many techniques utilized by surgeons to design optimal healing environments, maximize the efficacy of existing treatment modalities, and extract bacteria from a variety of wound situations resulting from burns, trauma, and disease. This new edition includes:In-depth examinations of a variety of clinical situationsFull colour photographsNew approaches to treat difficult-to-heal wounds, now including the open abdomen and SSIsNew chapters on «Advanced Therapies,» «The Role of Negative Pressure on Wound Therapy,» «Wound Dressings for Surgeons,» and «The Impact of Telemedicine in Wound Management.»