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Список книг автора Группа авторовClassical and Adaptive Clinical Trial Designs Using ExpDesign Studio
ExpDesign Studio facilitates more efficient clinical trial design This book introduces pharmaceutical statisticians, scientists, researchers, and others to ExpDesign Studio software for classical and adaptive designs of clinical trials. It includes the Professional Version 5.0 of ExpDesign Studio software that frees pharmaceutical professionals to focus on drug development and related challenges while the software handles the essential calculations and computations. After a hands-on introduction to the software and an overview of clinical trial designs encompassing numerous variations, Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio: Covers both classical and adaptive clinical trial designs, monitoring, and analyses Explains various classical and adaptive designs including groupsequential, sample-size reestimation, dropping-loser, biomarker-adaptive, and response-adaptive randomization designs Includes instructions for over 100 design methods that have been implemented in ExpDesign Studio and step-by-step demos as well as real-world examples Emphasizes applications, yet covers key mathematical formulations Introduces readers to additional toolkits in ExpDesign Studio that help in designing, monitoring, and analyzing trials, such as the adaptive monitor, graphical calculator, the probability calculator, the confidence interval calculator, and more Presents comprehensive technique notes for sample-size calculation methods, grouped by the number of arms, the trial endpoint, and the analysis basis Written with practitioners in mind, this is an ideal self-study guide for not only statisticians, but also scientists, researchers, and professionals in the pharmaceutical industry, contract research organizations (CROs), and regulatory bodies. It's also a go-to reference for biostatisticians, pharmacokinetic specialists, and principal investigators involved in clinical trials. ERRATUM Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio By Mark Chang The license for the ExpDesign Studio software on the CD included with this book is good for one-year after installation of the software. Prior to the expiration of this period, the software will generate a reminder about renewal for the license. The user should contact CTriSoft International (the owners of ExpDesign Studio) at www.CTriSoft.net or by email at [email protected], about renewal for the license. This should have been made clear in the first printing of this book. We apologize for this error.
The Informed Practice Nurse
This level of nurse works largely independently and their work is managed rather than supervised. They are able to demonstrate their duties to less experienced employees and supervise students, and can undertake surveys or audits. They may occasionally participate in research and development, clinical trials or equipment testing. The second edition of The Informed Practice Nurse offers both the new and experienced practice nurse the opportunity to reflect on their current practice. The chapter content is evidence based and accurately referenced, making it an essential text for students on undergraduate and post-graduate courses. Management and ethical issues in general practice are placed in context to government directives and the dynamic ethos of nursing. Women’s, men’s and young peoples health care are addressed in separate chapters, concentrating on health issues often neglected in other nursing texts and the health needs of lesbian women and gay men are discussed in a sensitive manner.
The Eye in Clinical Practice
The new edition of this highly successful book provides a concise and practical guide to eye disease for the non-specialist, avoiding jargon and giving clear guidance on the practical management of common eye complaints. Containing fully updated chapters, it provides the GP and optometrist with everything they need to know to enable them to deal with eye problems in primary care. The early sections describe the scope and limitations of eye care in general practice, including training, equipment and tests for ophthalmic disorders. The bulk of the text is confined to common symptoms of eye disease with particular emphasis on differential diagnosis. Later chapters describe systemic disorders with eye problems, eye trauma, surgery of the eye and the screening of asymptomatic patients. Appendices cover a formulary of ophthalmic practice, a list of suppliers, patient information, and a glossary of terms. A conversational style is used and patients' frequently asked questions are included. Advice is given on the use of basic equipment, on when to treat simple problems, and when to refer more complex ones. This book is well illustrated with full color photographs.
Polyklonale Antikörper
This book summarizes for the first time the fundamentals of the production of polyclonal antibodies. The individual steps of antigen preparation, immunization and antiserum production are described – clearly and with reference to application practice – starting from the initial planning. Particular attention is paid to the manifold aspects of animal husbandry- Finally, various possible applications for immunoglobulins are described. The authoress, who has been engaged in the production of antibodies for many years, makes her wide-ranging knowledge available to the reader and provides many valuable, practical hints for everyday work. A book written by a practical worker for practical workers. The individual topics covered are: immunological fundamentals, aims, chioce of antibody, choice of animal, antigens, preparation for immunization, administration, side effects of immunization, taking blood, antibody production.
The Epigenetics of Autoimmune Diseases
The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.
The Haemophilic Joints
Edited by an orthopaedic surgeon who is a leading specialist in the treatment of the musculo-skeletal complications of haemophilia.The Haemophilic Joints: New Perspectives reviews the different protocols for the orthopaedic management of the haemophilic articulations. The book draws together, in a single volume, the more recent perspectives of all the orthopaedic methods that can be applied in the diagnosis and treatment of the haemophilic joints from numerous specialists worldwide. It will be an invaluable resource for all those treating the articular problems in people with haemophilia.
The Eicosanoids
This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).
The Medical Job Interview
This book has been written specifically for busy junior doctors looking for that ‘competitive edge’. The medical interview is quite different from any other interview, but this book will help you prepare well in advance to optimize your chance of success. In this new edition, there are more details on how best to present your CV, different interview strategies to adopt, real-life example questions with answers good and bad, and information on what happens behind the scenes. This book provides all you need to know to be a winner in a medical interview. Read this book and nail that job! The Medical Job Interview Explains how to prepare the best curriculum vitae Tells you what you should do to get short listed Shows you how to find out who will be on the interview panel, and how you can anticipate their questions Gives tips on appropriate behaviour in an interview Advises you on negotiating salary and terms Reviews of first edition: “…I would whole heartedly recommend this book to anyone who is applying for a hospital position … I found it a real help during my preparation for applying for house jobs…” Cambridge Medicine “An excellent guide to the process of applying and getting hospital posts in the UK system…This book is a must for final year students, house officers and senior house officers who are looking for hospital posts and would not go amiss for those contemplating more senior appointments.” Senior House Officer in Medicine, Newcastle upon Tyne
Clinical Cases in Endodontics
A problem-based text that presents a wide range of real cases in endodontics Clinical Cases in Endodontics presents actual clinical cases, accompanied by academic commentary, that question and educate the reader about essential topics in endodontic therapy. It begins with sets of cases illustrating the most common diagnoses and the steps involved in preparing a treatment plan. Subsequent chapters continue in this style, presenting exemplary cases as the basis of discussing various treatment options, including nonsurgical root canal treatment, re-treatment, periapical surgery, internal and external resorption, emergencies and trauma, and treating incompletely developed apices. The progression from common to increasingly challenging clinical cases enables readers to build their skills, aiding the ability to think critically and independently. The Clinical Cases series is designed to recognize the centrality of clinical cases to the profession by providing actual cases with an academic backbone. Clinical Cases in Endodontics applies both theory and practice to real-life cases in a clinically relevant format. This unique approach supports the trend in case-based and problem-based learning, thoroughly covering the full range of endodontic treatment. Unique case-based format supports problem-based learning Promotes independent learning through self-assessment and critical thinking Covers all essential topics within endodontics Presents numerous illustrations and photographs throughout to depict the concepts described Clinical Cases in Endodontics is an ideal resource for students mastering endodontic treatment, residents preparing for board examinations, and clinicians wanting to learn the most recent evidence-based treatment protocols.
Diagnosis and Treatment of Furcation-Involved Teeth
Diagnosis and Treatment of Furcation-Involved Teeth offers dental professionals a comprehensive review of the aetiology and diagnosis of furcation defects, including treatment options. Provides a practical manual for the successful diagnosis and treatment of a therapeutic challenge for general dentists and periodontists Presents illustrative photographs of clinical cases and procedures Offers a helpful chapter on patient-reported outcomes Includes a companion website with video clips and case studies