Группа авторов
Список книг автора Группа авторовClinical Trials
Learn rigorous statistical methods to ensure valid clinical trials This Second Edition of the critically hailed Clinical Trials builds on the text's reputation as a straightforward and authoritative presentation of statistical methods for clinical trials. Readers are introduced to the fundamentals of design for various types of clinical trials and then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides commonsense solutions. The author bases the revisions and updates on his own classroom experience, as well as feedback from students, instructors, and medical and statistical professionals involved in clinical trials. The Second Edition greatly expands its coverage, ranging from statistical principles to controversial topics, including alternative medicine and ethics. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First Edition will discover completely new chapters, including: * Contexts for clinical trials * Statistical perspectives * Translational clinical trials * Dose-finding and dose-ranging designs Each chapter is accompanied by a summary to reinforce the key points. Revised discussion questions stimulate critical thinking and help readers understand how they can apply their newfound knowledge, and updated references are provided to direct readers to the most recent literature. This text distinguishes itself with its accessible and broad coverage of statistical design methods–the crucial building blocks of clinical trials and medical research. Readers learn to conduct clinical trials that produce valid qualitative results backed by rigorous statistical methods.
Robust Statistics
The first systematic, book-length treatment of the subject. Begins with a general introduction and the formal mathematical background behind qualitative and quantitative robustness. Stresses concepts. Provides selected numerical algorithms for computing robust estimates, as well as convergence proofs. Tables contain quantitative robustness information for a variety of estimates.
Spatial Statistics
The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. «Books such as this that bring together, clarify, and summarize recent research can lead to a great increase of interest in the area. . . . a major achievement in describing many aspects of spatial data and discussing, with examples, different methods of analysis.» –Royal Statistical Society «Dr. Ripley’s book is an excellent survey of the spatial statistical methodology. It is very well illustrated with examples [that] give a clear view of the wide scope of the subject, the way in which techniques often have to be tailored to particular applications, and the different sorts of spatial data that arise.» –The Bulletin of the London Mathematics Society Spatial Statistics provides a comprehensive guide to the analysis of spatial data. Each chapter covers a particular data format and the associated class of problems, introducing theory, giving computational suggestions, and providing examples. Methods are illustrated by computer-drawn figures. The book serves as an introduction to this rapidly growing research area for mathematicians and statisticians, and as a reference to new computer methods for researchers in ecology, geology, archaeology, and the earth sciences.
Financial Surveillance
This is the first book-length treatment of statistical surveillance methods used in financial analysis. It contains carefully selected chapters written by specialists from both fields and strikes a balance between the financial and statistical worlds, enhancing future collaborations between the two areas, and enabling more successful prediction of financial market trends. The book discusses, in detail, schemes for different control charts and different linear and nonlinear time series models and applies methods to real data from worldwide markets, as well as including simulation studies.
Discrete Distributions
There have been many advances in the theory and applications of discrete distributions in recent years. They can be applied to a wide range of problems, particularly in the health sciences, although a good understanding of their properties is very important. Discrete Distributions: Applications in the Health Sciences describes a number of new discrete distributions that arise in the statistical examination of real examples. For each example, an understanding of the issues surrounding the data provides the motivation for the subsequent development of the statistical models. Provides an overview of discrete distributions and their applications in the health sciences. Focuses on real examples, giving readers an insight into the utility of the models. Describes the properties of each distribution, and the methods that led to their development. Presents a range of examples from the health sciences, including cancer, epidemiology, and demography. Features discussion of software implementation – in SAS, Fortran and R – enabling readers to apply the methods to their own problems. Written in an accessible style, suitable for applied statisticians and numerate health scientists. Software and data sets are made available on the Web. Discrete Distributions: Applications in the Health Sciences provides a practical introduction to these powerful statistical tools and their applications, suitable for researchers and graduate students from statistics and biostatistics. The focus on applications, and the accessible style of the book, make it an excellent practical reference source for practitioners from the health sciences.
Risk Analysis
Everyday we face decisions that carry an element of risk and uncertainty. The ability to analyze, predict, and prepare for the level of risk entailed by these decisions is, therefore, one of the most constant and vital skills needed for analysts, scientists and managers. Risk analysis can be defined as a systematic use of information to identify hazards, threats and opportunities, as well as their causes and consequences, and then express risk. In order to successfully develop such a systematic use of information, those analyzing the risk need to understand the fundamental concepts of risk analysis and be proficient in a variety of methods and techniques. Risk Analysis adopts a practical, predictive approach and guides the reader through a number of applications. Risk Analysis: Provides an accessible and concise guide to performing risk analysis in a wide variety of fields, with minimal prior knowledge required. Adopts a broad perspective on risk, with focus on predictions and highlighting uncertainties beyond expected values and probabilities, allowing a more flexible approach than traditional statistical analysis. Acknowledges that expected values and probabilities could produce poor predictions – surprises may occur. Emphasizes the planning and use of risk analyses, rather than just the risk analysis methods and techniques, including the statistical analysis tools. Features many real-life case studies from a variety of applications and practical industry problems, including areas such as security, business and economy, transport, oil & gas and ICT (Information and Communication Technology). Forms an ideal companion volume to Aven’s previous Wiley text Foundations of Risk Analysis. Professor Aven’s previous book Foundations of Risk Analysis presented and discussed several risk analysis approaches and recommended a predictive approach. This new text expands upon this predictive approach, exploring further the risk analysis principles, concepts, methods and models in an applied format. This book provides a useful and practical guide to decision-making, aimed at professionals within the risk analysis and risk management field.
Data Analysis
The first part of this book is devoted to methods seeking relevant dimensions of data. The variables thus obtained provide a synthetic description which often results in a graphical representation of the data. After a general presentation of the discriminating analysis, the second part is devoted to clustering methods which constitute another method, often complementary to the methods described in the first part, to synthesize and to analyze the data. The book concludes by examining the links existing between data mining and data analysis.
Sampling Statistics
Discover the latest developments and current practices in survey sampling Survey sampling is an important component of research in many fields, and as the importance of survey sampling continues to grow, sophisticated sampling techniques that are both economical and scientifically reliable are essential to planning statistical research and the design of experiments. Sampling Statistics presents estimation techniques and sampling concepts to facilitate the application of model-based procedures to survey samples. The book begins with an introduction to standard probability sampling concepts, which provides the foundation for studying samples selected from a finite population. The development of the theory of complex sampling methods is detailed, and subsequent chapters explore the construction of estimators, sample design, replication variance estimation, and procedures such as nonresponse adjustment and small area estimation where models play a key role. A final chapter covers analytic studies in which survey data are used for the estimation of parameters for a subject matter model. The author draws upon his extensive experience with survey samples in the book's numerous examples. Both the production of «general use» databases and the analytic study of a limited number of characteristics are discussed. Exercises at the end of each chapter allow readers to test their comprehension of the presented concepts and techniques, and the references provide further resources for study. Sampling Statistics is an ideal book for courses in survey sampling at the graduate level. It is also a valuable reference for practicing statisticians who analyze survey data or are involved in the design of sample surveys.
Quantitative Finance
A rigorous, yet accessible, introduction to essential topics in mathematical finance Presented as a course on the topic, Quantitative Finance traces the evolution of financial theory and provides an overview of core topics associated with financial investments. With its thorough explanations and use of real-world examples, this book carefully outlines instructions and techniques for working with essential topics found within quantitative finance including portfolio theory, pricing of derivatives, decision theory, and the empirical behavior of prices. The author begins with introductory chapters on mathematical analysis and probability theory, which provide the needed tools for modeling portfolio choice and pricing in discrete time. Next, a review of the basic arithmetic of compounding as well as the relationships that exist among bond prices and spot and forward interest rates is presented.? Additional topics covered include: Dividend discount models Markowitz mean-variance theory The Capital Asset Pricing Model Static?portfolio theory based on the expected-utility paradigm Familiar probability models for marginal distributions of returns and the dynamic behavior of security prices The final chapters of the book delve into the paradigms of pricing and present the application of martingale pricing in advanced models of price dynamics. Also included is a step-by-step discussion on the use of Fourier methods to solve for arbitrage-free prices when underlying price dynamics are modeled in realistic, but complex ways. Throughout the book, the author presents insight on current approaches along with comments on the unique difficulties that exist in the study of financial markets. These reflections illustrate the evolving nature of the financial field and help readers develop analytical techniques and tools to apply in their everyday work. Exercises at the end of most chapters progress in difficulty, and selected worked-out solutions are available in the appendix. In addition, numerous empirical projects utilize MATLAB® and Minitab® to demonstrate the mathematical tools of finance for modeling the behavior of prices and markets. Data sets that accompany these projects can be found via the book's FTP site. Quantitative Finance is an excellent book for courses in quantitative finance or financial engineering at the upper-undergraduate and graduate levels. It is also a valuable resource for practitioners in related fields including engineering, finance, and economics.
Linear Models
An insightful approach to the analysis of variance in the study of linear models Linear Models explores the theory of linear models and the dynamic relationships that these models have with Analysis of Variance (ANOVA), experimental design, and random and mixed-model effects. This one-of-a-kind book emphasizes an approach that clearly explains the distribution theory of linear models and experimental design starting from basic mathematical concepts in linear algebra. The author begins with a presentation of the classic fixed-effects linear model and goes on to illustrate eight common linear models, along with the value of their use in statistics. From this foundation, subsequent chapters introduce concepts pertaining to the linear model, starting with vector space theory and the theory of least-squares estimation. An outline of the Helmert matrix is also presented, along with a thorough explanation of how the ANOVA is created in both typical two-way and higher layout designs, ultimately revealing the distribution theory. Other important topics covered include: Vector space theory The theory of least squares estimation Gauss-Markov theorem Kronecker products Diagnostic and robust methods for linear models Likelihood approaches to estimation A discussion of Bayesian theory is also included for purposes of comparison and contrast, and numerous illustrative exercises assist the reader with uncovering the nature of the models, using both classic and new data sets. Requiring only a working knowledge of basic probability and statistical inference, Linear Models is a valuable book for courses on linear models at the upper-undergraduate and graduate levels. It is also an excellent reference for practitioners who use linear models to conduct research in the fields of econometrics, psychology, sociology, biology, and agriculture.