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    Modern Carbonylation Methods

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    Comprehensively covering modern carbonylation chemistry, this book is an indispensable companion for all synthetic chemists working in industry and academia. This monograph contains everything there is to know from recent advances in the investigation of carbonylation catalysts, via coordination chemistry to the synthetic application of transition metal catalyzed carbonylations.

    Amino Group Chemistry

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    Here, probably the most important functional group in organic chemistry is discussed in one handy volume. The monograph covers its application – from natural products to synthetic pharmaceuticals – detailing complex syntheses using the amino group as templates and modern techniques focussing on the introduction of the amino group. A definitive must-have for every chemist.

    Modern Carbonyl Chemistry

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    The carbonyl group is undoubtedly one of the most important functional groups in organic chemistry, both in its role as reactive center for synthesis or derivatisation and as crucial feature for special structural or physiological properties. Vast and profound progress has been made in all aspects modern carbonyl chemistry. These achievements are, however, rather dispersed in the literature and it is often not easy for the researcher obtain a comprehensive overview of a relevant topic. Modern Carbonyl Chemistry overcomes this inconvenience by collating the information for appropriate themes. In this work internationally renowned experts and leaders in the field have surveyed recent aspects and modern features in carbonyl chemistry, such as cascade-reactions, one-pot-syntheses, recognition, or site differentiation.

    Modern Amination Methods

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    Organic compounds containing amino groups are at the center of modern organic chemistry, and are widely used in the pharmaceutical industry, crop protection, natural product chemistry, and in advanced materials. Modern methods for the introduction of the amino group are therefore of major importance to synthetic chemists and product developers. Over the last decade, many methods have been developed to generate new C-N bonds. At the same time, the pharmaceutical and chemical industry was rapidly moving away from the development of racemic compounds to the direct synthesis of enantiomerically pure materials. The articles of this book, written by internationally recognized experts, thus focus on asymmetric synthesis. The most recent catalytic amination methods have particularly revolutionized the chemistry of amino compounds – and you find them all in this first comprehensive overview.

    Modern Carbonyl Olefination

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    While this important reaction class is among the most important and most widely used in organic chemistry, this is the first book to summarize the many different olefination methods, including: * Wittig reaction * Peterson reaction * Julia olefination * Utilizing the Tebbe and related reagents * Low-valent chromium, zinc or titanium mediated olefination * McMurry coupling plus the related reactions in each case and the application to asymmetric synthesis. It thus collates in one ready reference the current level of knowledge as well as new developments in this constantly evolving field – information which until now has been dispersed throughout the literature.

    Modern Oxidation Methods

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    At the very latest, with the award of the 2001 Nobel Prize for work on asymmetric oxidation, there has been a need for a comprehensive book on such methods. Edited by J.-E. Backvall, one of the world's leaders in the field, this book fills that gap by covering the topic, from classical to green chemistry methods. He has put together a plethora of well-established authors from all over the world who cover every important aspect in high-quality contributions – whether aerobic oxidation or transition metal-catalyzed epoxidation of alkenes. By providing an overview of this huge topic, this book represents an unparalleled aid for any chemist working in the field. Chapters include: Recent Developments in the Osmium-Catalyzed Dihydroxylation of Olefins Transition Metal-Catalyzed Epoxidation of Alkenes Organocatalytic Oxidation – Ketone-Catalyzed Asymmetric Epoxidation of Olefins Modern Oxidation of Alcohols using environmentally Benign Oxidants Aerobic Oxidations and Related Reactions Catalyzed by N-Hydroxyphthalimide Ruthenium-Catalyzed Oxidation of Alkenes, Alcohols, Amines, Amides, b-Lactams, Phenols, and Hydrocarbons Selective Oxidations of Sulfides and Amines Liquid Phase Oxidation Reactions Catalyzed by Polyoxometalates Oxidation of Carbonyl Compounds Mn-catalysed Oxidation with Hydrogen Peroxide

    Modern Organonickel Chemistry

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    Organonickel chemistry plays an increasingly important role in organic chemistry, and interest in this topic is now just as keen as in organopalladium chemistry. While there are numerous, very successful books on the latter, a book specializing in organonickel chemistry is long overdue. Edited by one of the leading experts in the field, this volume covers the many discoveries made over the past 30 years, and previously scattered throughout the literature. Active researchers working at the forefront of organonickel chemistry provide a comprehensive review of the topic, including cross-coupling reactions, asymmetric synthesis and heterogeneous catalysis reaction types. A must-have for both organometallic chemists and synthetic organic chemists.

    Modern Fluoroorganic Chemistry

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    In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides. This long-awaited book represents an indispensable source of high quality information for everyone working in the field.

    Persistent Organic Pollutants

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    Persistent Organic Pollutants (POPs) are toxic, resistant to degradation, bioaccumulative, and display wide spatial distribution. They accumulate in humans and wildlife, and have been linked to cancer, as well as reproductive and immunological disorders. In 2001 a global treaty on POPs was agreed, to minimise and ultimately eliminate the release of POPs into the environment. The Stockholm Convention lists 12 groups of chemicals, and as of late 2008, a further 12 chemicals are under consideration for inclusion. This book addresses all of these chemicals, but focuses particularly on currently listed POPs that are still of major concern (e.g. polychlorinated biphenyls – PCBs), as well as new and emerging POPs that have been the subject of an explosion of scientific interest in the last decade, i.e. brominated flame retardants (BFRs) and perfluorinated chemicals (PFCs). Other chapters address the challenges posed by the presence of POPs in the developing world; how the properties of chiral POPs can provide unique insights into their environmental sources, fate and behaviour; and issues arising from the presence of POPs in urban and indoor environments. Persistent Organic Pollutants provides a much-anticipated reference source for a wide audience including academics, industrial scientists and regulators.

    Fluorinated Heterocyclic Compounds

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    A thorough survey of synthetic methods, chemistry, and applications of major classes of fluorinated heterocycles Merging organic, heterocyclic, and fluoroorganic chemistry, fluorinated heterocyclic compounds have distinctively desirable properties suitable for use in pharmaceuticals and agrichemicals, especially their ability to penetrate the cell membrane barrier for drug absorption. Offering a needed overview of this relatively new addition to the heterocyclic family, this essential reference provides the latest state-of-the-art information on key application areas within fluorine chemistry. With contributions from experts from both industry and academia, the book covers the chemistry, synthesis, and applications of fluorinated heterocycles with chapters on: Three-, four-, five-, six-, and seven-membered fluorine-containing heterocycles Fluorinated nucleosides Fluorointermediates Applications of fluorinated heterocycles in agricultural products Pharmaceuticals containing fluorinated heterocycles Technical applications of fluorinated heterocycles Written by a team of world-recognized experts in the area of organic and industrial chemistry of fluorine, Fluorinated Heterocyclic Compounds: Synthesis, Chemistry, and Applications will prove valuable to both students and researchers from academia and industry seeking further knowledge of the synthetic methods, chemistry, and applications of major classes of fluorinated heterocycles.