Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. «Science of Synthesis: Metal-Catalyzed Cyclization Reactions» presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 1 covers intramolecular coupling reactions (including Heck reactions), intramolecular allylations, and cyclopropane and cyclopropene ring openings. Also included are cyclization reactions of alkenes, alkynes, and allenes, cycloisomerizations, and intramolecular C-N and C-O bond formation.
Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. «Science of Synthesis: Metal-Catalyzed Cyclization Reactions» presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
Surgical Wound Healing and Management, Second Edition explores the critical role of surgery in wound bed preparation and management, and provides a sound knowledge of wound mechanisms, physiology, and metabolic control. Founded on the expertise of internationally recognized authorities, this source illustrates the many techniques utilized by surgeons to design optimal healing environments, maximize the efficacy of existing treatment modalities, and extract bacteria from a variety of wound situations resulting from burns, trauma, and disease. This new edition includes:In-depth examinations of a variety of clinical situationsFull colour photographsNew approaches to treat difficult-to-heal wounds, now including the open abdomen and SSIsNew chapters on «Advanced Therapies,» «The Role of Negative Pressure on Wound Therapy,» «Wound Dressings for Surgeons,» and «The Impact of Telemedicine in Wound Management.»
Plastic surgery after massive weight loss is one of the fastest-growing areas in plastic surgery today. With the problem of obesity approaching epidemic proportions, an increasing number of patients who have had bariatric surgery are now turning to plastic surgeons for body contouring to remove excess skin remaining after massive weight loss. These procedures and the skillful surgeons who perform them are now in high demand. Body Contouring after Massive Weight Loss is the first major work on this important topic by one of the preeminent experts, Dr. Al Aly, and a group of outstanding contributors. This comprehensive book is filled with useful information to help plastic surgeons understand the special needs of the massive weight loss patient and to skillfully and safely plan and execute the operations necessary for contouring each body region. Each chapter is organized in a consistent format, with indications and contraindications, patient evaluation, planning, staging of procedures, operative technique, postoperative care, tips and tricks, and problems and complications. This beautiful, four-color semi-atlas provides clear, step-by-step instruction for performing body contouring procedures in each anatomic area. Comprehensive chapters are included on the range of contouring operations, including: belt lipectomy and lower body lift, central body lift, thigh lift, buttock lift and buttock augmentation, large volume liposuction and body contouring, brachioplasty, and upper body lift. Each procedure is liberally illustrated with medical art as well as numerous preoperative, intraoperative, and postoperative images to demonstrate the technical nuances of these operations and the possible results that can be achieved. To complement this book, 2 DVDs are included with operative video: one on upper body lift and one on belt lipectomy. For the plastic surgeon wishing to expand his or her practice into post-bariatric surgery, Body Contouring After Massive Weight Loss is a must. No other source provides so much sound, practical advice or such complete coverage.
Although there have been significant advancements in minimally invasive spinal surgery techniques in the last few decades, optimal outcomes for chronic low back pain remain elusive. A number of promising clinical trials have been conducted using tissue engineering and biological interventions for disc degeneration. Written by renowned innovators, this is the first book that covers implementation of these groundbreaking approaches for disc disease. The text begins with key fundamentals including anatomy and physiology, pathophysiology, imaging and biomechanics to delineate healthy versus diseased spine. Subsequent sections discuss treatment strategies, research findings, and future developments. Throughout each chapter, renowned spine surgeons and scientists share clinical pearls gleaned from hands-on experience. Key Highlights The current state of the art in biological and tissue engineering procedures for spinal disordersTreatment methodologies including nucleus replacement and repair, annulus fibrosus repair, total disc transplantation, and mechanical total disc replacementInnovative treatment strategies for disc regeneration, such as genes and proteinsGrowth factors including platelet-rich plasma (PRP), which has shown promise for the stimulation and acceleration of bone and soft tissue healingCell-based therapy for spinal disc regeneration and repair including the use of stem cells and chondrocytesIn-depth discussion of research including animal versus human model, in-vitro, and a summary of biologic clinical trialsThis is a must-have resource for trainee and practicing orthopaedic surgeons and neurosurgeons who treat patients for spine-related conditions. It is essential reading for all clinicians who have an interest in cutting-edge tissue engineering and biological treatment interventions.
This timely source comprehensively examines the reconstructive issues faced in the treatment of burn survivors and thoroughly reviews key principles in the care of thermal, chemical, and electrical injuries – clearly demonstrating new and effective techniques for the reconstruction and rehabilitation of burn patients.
A collaboration between some of the leading international experts in the field, AOCMF proudly presents Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research , which unravels the many biologic processes and risk factors associated with this debilitating condition. With its unknown pathophysiology, lack of established management regimens, and because of the millions of patients currently taking antiresorptive agents, this important book on ARONJ has been produced to provide the latest in contemporary evidence and insight. The book's key features include: Detailed analysis of the historical definitions, classifications, and clinical features of ARONJReview of the risk factors and treatment options currently available, and why the jaw bone is predominantly affectedDiscussion on the use of large and small animals in modelling.With dozens of clinical images to help illustrate the impact of this condition on real patients, Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research is an excellent resource for anyone involved or interested in this important medical field.
Operative Procedures in Plastic, Aesthetic and Reconstructive Surgery is a comprehensive, step-by-step guide to the most common plastic, aesthetic, and reconstructive procedures. Few resources in the field provide such a detailed description of commonly performed operations in one place. Each chapter presents a well-documented technique for a specific clinical diagnosis. It discusses preoperative markings, intraoperative details, postoperative instructions, and avoidance of complications for each surgical procedure presented. The authors use extensive clinical photographs, drawings, and detailed descriptions to guide readers through each procedure. A list of the essential equipment required for each operation is provided. In addition, the book includes a list of commonly accepted CPT codes associated with the described procedure. In all, 32 procedures are presented including skin grafting, breast reconstruction, liposuction, carpal tunnel release, breast augmentation, brow lift, orbital floor fracture, mandible fracture management, lower extremity reconstruction, and more. Written by experts in plastic and reconstructive surgery worldwide, this book is a valuable resource for practicing plastic surgeons as well as residents and fellows in plastic surgery.
Current statistics indicate that 75-80% of people worldwide will experience some form of back pain during their lifetime. Lumbar pain is a leading cause of disability – a global public health burden with serious economic implications. Written by internationally renowned spine experts, the 8th volume in the AOSpine Masters series is a concise, state-of-the-art overview on fundamental management strategies and current issues and challenges. The text covers the full age spectrum – from childhood to older adulthood – and contributing factors such as the sacroiliac joints, genetics, and spine infections. Clinical evaluation, treatment options, recent research advances, and future perspectives are systematically examined and presented in a clear format. With commentary from leading authorities, this compendium presents candid discussion of significant challenges faced by clinicians who treat back pain. Among the issues addressed are managing patients who have undergone multiple operations, chronic back pain, failed spine surgery, and what to do when all nonsurgical and surgical options have been exhausted. Key Highlights Economic considerations, risk factors, and legal aspectsNeurological causes, including myopathies, neuromuscular disease, Parkinson disease,and dystoniaConservative treatment options such as drugs, physiotherapy, and complementary medicineThe role of minimally invasive surgery in treating degenerative lumbar spine diseaseMust-read bibliographic references in every chapterBullet lists of pearls and pitfalls summarize critical points and key conceptsThe AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care.
Originally published in 2006, the second edition of this award-winning neurosurgical atlas is written by a notable cadre of world-renowned spine surgeons. Reflecting the enormous depth and breadth of spine surgery, this volume has been completely updated with current, state-of-the-art surgical methodologies and minimally invasive options. Pathologies include degenerative changes, congenital abnormalities, rheumatic diseases, tumors, and trauma.The authors have divided the book into six consistent sections: occipital-cervical, midcervical spine, cervicothoracic junction, thoracic and thoracolumbar spine, lumbar and lumbosacral spine, and peripheral nerve. Within each section, the opening chapters cover comprehensive discussion of pathology, etiology, and differential diagnosis. Succeeding chapters present step-by-step surgical techniques encompassing anterior, anterolateral, posterior, and posterolateral approaches, separately and in sequence. Minimally invasive techniques and peripheral nerve procedures, including the brachial plexus, lumbosacral plexus, and individual nerves are covered independently, following the same organization.Key Highlights:Clearly delineated indications, contraindications, advantages, and disadvantages provided for each surgeryOperations with same opening and closing technique covered just once, thereby minimizing redundancyBeautifully illustrated with more than 1,000 imagesVideo compendium created by master surgeons provides up-close guidance on a wide array of surgical proceduresIdeal for both the busy practitioner seeking review and resident looking for robust study materialsThis book is an incomparable learning tool for residents, who will likely read it several times during the course of residency. A precisely edited, didactic atlas, neurosurgeons and orthopaedic surgeons will also find it an invaluable resource.