Fundamentals of Cancer Detection, Treatment, and Prevention. Surya K. De

skin tone, individuals with any color skin can develop skin cancer [77,78].

Figure 2.10 Role of sunlight on cancer.

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People of all ages and skin tones are recommended to limit the amount of time they spend in the sun, especially between 10:00 am and 4:00 pm, when the sun's rays are the most intense. Keep in mind that UV radiation is reflected by sand, water, snow, and ice, and it can penetrate windshield and window glass. For anyone planning to be outside for over 15 minutes, it is advisable to apply sunscreen generously and repeatedly, stay in the shade as much as possible, and wear protective clothing. Tightly woven, loose‐fitting clothes that cover most areas of exposed skin work best. Choose bright or dark colors as these reflect more UV radiation than pastels or bleached fabrics.

Other sources of UV radiation, such as tanning beds, should also be avoided (Figure 2.11). According to the Skin Cancer Foundation, people who use a tanning bed before age 35 increase their chance of developing melanoma (skin cancer) by 75%.

Figure 2.11 Role of tanning beds on cancer.

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2.12 Role of Radon on Cancer

Radon (Rn) is a radioactive, colorless, odorless, tasteless noble gas, given off by rocks and soil as the radioactive element radium (Ra) breaks down. Radium, which is formed when the radioactive elements uranium (U) and thorium (Th) break down, was discovered by Marie and Pierre Curie in 1898. People who are exposed to high levels of radon may have an increased risk of lung cancer [80,81].

      Some parts of the United States have higher levels of radon in their rocks and soil, and for this reason, affordable radon test kits have been developed to assess the amount of this gas in individual homes. The test kits are available at most hardware stores. There are several ways to reduce home radon to a safe level.

2.13 Known Human Carcinogens

      2.13.1 Arsenic, Coal Tar, Coal‐tar Pitch, Diesel, Asbestos, Formaldehyde, and Air Pollutants

Arsenic is a widely distributed, natural element found in the Earth's crust. In its inorganic form, it is toxic to the human body and a known carcinogen [82]. It reaches people through contaminated drinking water in less‐developed countries such as Bangladesh, and it can find its way into food produced from crops irrigated with arsenic‐contaminated water (Figure 2.12).

Figure 2.12 Arsenic causes cancer.

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      The WHO estimates that at least 140 million people in 50 countries drink water containing high levels of arsenic. In addition, arsenic is one of the cancer‐causing agents in tobacco.

Coal tar and coal‐tar pitch are coal derivatives widely used for various commercial and industrial purposes. Research findings suggest that miners who are exposed to the process of coal gasification and other occupational workers involved (Figure 2.13) with coal tar or coal‐tar pitch suffer significantly higher rates of skin cancer and cancers of the lungs, bladder, kidney, and digestive tract [83,84].

Figure 2.13 Coal exposure can cause cancer.

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Diesel exhaust from the burning of diesel oil has over 30 components (Figure 2.14) that can cause various types of cancer, according to the International Agency for Research on Cancer [85–95].

Figure 2.14 Exposure of diesel exhaust can cause cancer.

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Fracking is the process of drilling down into the lower layers of the earth and injecting liquid at high pressure, in order to force open existing fissures and extract oil or gas (Figure 2.15). During this technique, however, cancer‐causing compounds including benzene and formaldehyde may be released into the air and groundwater [96].

Figure 2.15 Exposure to fracking can cause cancer.

Asbestos is a naturally occurring mineral substance that has a fibrous structure. For this reason, it can be pulled into a fluffy consistency. Asbestos was used as an insulation material (Figure 2.16) for years before the dust was linked to lung cancer [98]. It is also linked to mesothelioma, another serious and potentially fatal disease (see later chapter on Mesothelioma).

Figure 2.16 Exposure to asbestos causes lung cancer.

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Products that contain asbestos are not completely banned in the United States, though the Environmental Protection Agency (EPA) regulates their use.

Formaldehyde is a chemical compound used as a constituent of certain building materials and some types of glue, as well as a preserving agent and disinfectant (Figure 2.17). Scientists have known for years that formaldehyde can cause nasal cancer in rats, and the International Agency for Research on Cancer reports that it is a carcinogen for humans also [99–104].

Figure 2.17 Formaldehyde can cause cancer.

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      Air