Im zweiten Band dieses modular aufgebauten Lehrbuchs wird die Exposition und toxische Wirkung der wichtigsten toxischen Chemikalien abgehandelt. (Nano-)Partikulare Stoffe, Metalle, anorganische und organische Verbindungen werden systematisch betrachtet und in ihren chemischen Eigenschaften, Expositionen, Wirkmechanismen und Toxikodynamik beschrieben, erganzt durch experimentelle Daten von Mensch und Tier. Ein besonderes Highlight ist das Kapitel uber chemische Kampfstoffe, das in Zusammenarbeit mit Fachleuten der Bundeswehr entstanden ist. Leseempfehlungen und Fragen zur Selbstkontrolle runden dieses Buch ab. Zusammen mit dem ersten Band («Grundlagen der Toxikologie») enthalt dieses Buch das gesamte Grundlagenwissen fur die Ausbildung zum Fachtoxikologen und fur den Masterstudiengang Toxikologie. Begleitmaterial fur Dozenten verfugbar unter www.wiley-vch.de/textbooks
Perfekt abgestimmt auf die moderne Ausbildung zum Toxikologen, werden in diesem Lehr- und Prüfungsbuch alle wichtigen Konzepte und wissenschaftlichen Grundlagen der Toxikologie erklärt: von der molekularen Toxikologie bis hin zu Risk Assessment und Epidemiologie. Besonderes Highlight sind mehrere Kapitel zu den aktuellen Hauptarbeitsfeldern der Toxikologie, u.a. die Kontrolle und Bewertung von Belastungen am Arbeitsplatz und in Gebäuden sowie des Gefahrenpotentials von Nahrungs- und Arzneimitteln. Leseempfehlungen und Fragen zur Selbstkontrolle runden dieses Buch ab. Zusammen mit dem zweiten Band («Toxikologie der Stoffe») ist das gesamt Grundlagenwissen für die Ausbildung zum Fachtoxikologen und für den Masterstudiengang Toxikologie enthalten. Begleitmaterial für Dozenten verfügbar unter www.wiley-vch.de/textbooks
Ob es um Tinte, Farben, Genussmittel, Zundholzer, Pharmazeutika oder gar den Stein der Weisen geht: Chemie und Kulturgeschichte sind nicht voneinander zu trennen. Besonders anschaulich wird das, wenn chemische Experimente in historischem Ambiente vorgefuhrt werden. Zwischen Rheinsberg in Brandenburg und Tettnang am Bodensee finden in Schlossern, Museen und Klostern die Experimentalvortrage statt, auf denen aufbauend dieses Buch entstand. Nun in der zweiten Auflage, sind weitere Experimente dazugekommen, die sich zum Beispiel mit Silber und Gold, Tod und Teufel beschaftigen. Die Dichte der historischen Standorte auf der Deutschlandkarte nimmt zu: vom Bergbau im Harz bis «Doktor Faustus» im Kloster Maulbronn.
Als es Wissenschaftlern an der Technischen Universität Wien im Jahr 2001 zum ersten Mal gelang, Lichtblitze zu produzieren, die nur noch Attosekunden dauern, bedeutete dies den Beginn einer neuen Disziplin in den Naturwissenschaften: Die Attosekundenphysik war geboren! Jetzt sollte es möglich sein, Elektronen zu fotografieren und damit dem Mikrokosmos einige seiner am strengsten gehüteten Geheimnisse zu entreißen. Denn was im Inneren der Elektronenhülle von Atomen vor sich geht, war bis dahin experimentell nicht zu beobachten. Mit ultrakurzen Lichtblitzen, die nur wenige Milliardstel einer milliardstel Sekunde dauern, begann man einzutauchen in eine fremdartige, von der Quantenmechanik bestimmte Welt. Spektakuläre Bilder aus dem Inneren von Atomen entstanden. Erstmals konnte man beobachten wie sich Elektronen – etwa nach einer Anregung durch Licht – bewegen. Die Attosekundenphysik ist eine junge Wissenschaft mit dem Potential, viele weiße Flecken auf der Landkarte des Mikrokosmos mit Farbe zu füllen. Ultraschneller Tauchgang in die Atome erzählt die Geschichte der Attosekundenphysik. Aufbauend auf den Grundlagen der Quantenmechanik und Laserphysik erklärt das Buch, wie Elektronen fotografiert werden, und schildert – anschaulich für an Naturwissenschaften Interessierte – zahlreiche Erkenntnisse, die uns die Attosekundenphysik bis heute eingebracht hat. Wohin wird der Weg der Erkundung dieser Quantenteilchen führen?
What makes online learning engaging to students? Engagement depends upon designing learning that is active and collaborative, authentic and experiential, constructive and transformative. While students and instructors can inadvertently act in several ways to decrease student engagement in online coursework, research indicates a range of options that have been proven to engage students in their online courses. This report explores the learning theories, pedagogies, and active learning options that encourage student engagement, push them to think more deeply, and teach them how to learn. It guides instructors on how to evaluate the effectiveness of technological and software tools, and to evaluate and assess the activities, learning, and retention occurring in their online classes. Finally, it will help instructors find inspiration for engagement from the face-to-face settings that can be translated into the online environment. This is the 6th issue of the 40th volume of the Jossey-Bass series ASHE Higher Education Report. Each monograph is the definitive analysis of a tough higher education issue, based on thorough research of pertinent literature and institutional experiences. Topics are identified by a national survey. Noted practitioners and scholars are then commissioned to write the reports, with experts providing critical reviews of each manuscript before publication.
From the magazines and newspapers of the mid-1800s to movies and apps of the twenty-first century, popular culture and media in the United States provide prolific representations of higher education. This report positions artifacts of popular culture as pedagogic texts able to (mis)educate viewers and consumers regarding the purpose, values, and people of higher education. It: Discusses scholarly literature across disciplines Examines a diverse array of cross-media artifacts Reveals pedagogical messages embedded in popular culture texts to prompt thinking about the multiple ways higher education isrepresented to society through the media. Informative and engaging, higher education professionals can use the findings to intentionally challenge the (mis)educating messages about higher education through programs, policies, and perspectives. This is the 4th issue of the 40th volume of the Jossey-Bass series ASHE Higher Education Report. Each monograph is the definitive analysis of a tough higher education issue, based on thorough research of pertinent literature and institutional experiences. Topics are identified by a national survey. Noted practitioners and scholars are then commissioned to write the reports, with experts providing critical reviews of each manuscript before publication.
Institutional diversity serves as one of the fundamental hallmarks of American higher education. After a long history of support for many institutional types, the past 40 years have seen a decline in institutional variety. Through a discussion of history, theoretical contexts, and causes of homogenization, this monograph examines how higher education policymakers and leaders can strengthen institutional mission and preserve the benefits of institutional diversity. Higher education needs to serve a variety of functions for students, from liberal arts education to vocational training programs. No single institution or institutional type can adequately fulfill all of these roles, and this monograph considers the rewards and challenges of maintaining a healthy, beneficial diversity. It also covers the roles, purposes, trials, and benefits of institutional diversity. It provides practical examples and theoretical perspectives useful in understanding the complexities of higher education systems and the external pressures faced by colleges and universities that challenge institutional mission and threaten institutional diversity and its well-established benefits for students and society. This is the third issue of the 39th volume of the Jossey-Bass series ASHE Higher Education Report. Each monograph is the definitive analysis of a tough higher education issue, based on thorough research of pertinent literature and institutional experiences. Topics are identified by a national survey. Noted practitioners and scholars are then commissioned to write the reports, with experts providing critical reviews of each manuscript before publication.
An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.
A porous medium is composed of a solid matrix and its geometrical complement: the pore space. This pore space can be occupied by one or more fluids. The understanding of transport phenomena in porous media is a challenging intellectual task. This book provides a detailed analysis of the aspects required for the understanding of many experimental techniques in the field of porous media transport phenomena. It is aimed at students or engineers who may not be looking specifically to become theoreticians in porous media, but wish to integrate knowledge of porous media with their previous scientific culture, or who may have encountered them when dealing with a technological problem. While avoiding the details of the more mathematical and abstract developments of the theories of acroscopization, the author gives as accurate and rigorous an idea as possible of the methods used to establish the major laws of macroscopic behavior in porous media. He also illustrates the constitutive laws and equations by demonstrating some of their classical applications. Priority is to put forward the constitutive laws in concrete circumstances without going into technical detail. This third volume in the three-volume series focuses on the applications of isothermal transport and coupled transfers in porous media.
This book presents tools and algorithms required to compress/uncompress signals such as speech and music. These algorithms are largely used in mobile phones, DVD players, HDTV sets, etc. In a first rather theoretical part, this book presents the standard tools used in compression systems: scalar and vector quantization, predictive quantization, transform quantization, entropy coding. In particular we show the consistency between these different tools. The second part explains how these tools are used in the latest speech and audio coders. The third part gives Matlab programs simulating these coders.