Brings together key new results of interdisciplinary collaborations among various research fields on rhodopsin including the photoreceptive mechanism of rhodopsins, the molecular mechanism of the visual transduction process, visual processes in the retina and other transduction processes in the retina and brain. The structures of the rhodopsin molecule are studied in the fields of protein chemistry, molecular biology, organic chemistry and structural biology; the ultra fast reactions of the retinal protein are studied in physics, biophysics, physical chemistry, organic chemistry and photobiology; the phototransduction in retinal proteins and visual cells are studied in biophysics, biochemistry, biophysical chemistry and photobiology; and the localization in the tissues is studied in anatomy and histochemistry. The diversity of visual systems in various animals is studied in zoology and comparative biochemistry.
Working on Corticotropin-Releasing Factor in a variety of systems, experts present a coherent depiction of this peptide's role in the control and coordination of the response to stress-inducing situations.
Incontinence is a very common and often devastating problem, but one that goes largely unacknowledged. In order to elucidate the underlying mechanisms of this major clinical condition, this symposium brought together neuroscientists working on the basic biology of the bladder and bowel and clinicians dealing with the various manifestations of urinary and fecal incontinence. The resulting coverage is broad and includes papers on the innervation and functional anatomy of the urinary tract and anorectal region, and the central neural control of these areas. Other contributions discuss the functional assessment of the anorectum and bladder, stress incontinence and the neurogenic hypothesis of incontinence, detrusor-external sphincter dyssynergia, and pharmacological and surgical approaches to treatment.
Parkinson's disease, Alzheimer's disease, and motor neuron disease share a significant common feature: selective death of neurons in restricted regions of the brain. This international symposium, held by the Ciba Foundation in 1986, is the first to bring together neurophysiologists working on neuronal death and neuropathologists dealing with human degenerative brain disease. Participants describe the causes and sequence of events leading to neuronal death and discuss what can be done to prevent it. Among the topics covered are recent advances in the understanding of agents such as trophic factors, excitotoxins and poisons that are known to be involved in neuronal death; examples of neuronal death during normal development; and the role played by endocrine mechanisms and neuronal activity. Also considers trophic factors controlling the survival of neuronal transplants and the therapeutic prospects for tissue transplantation.
Neurology is primarily characterized by a variety of diseases which seem very similar and are therefore difficult to distinguish between. Skill at differential diagnosis is therefore absolutely paramount. Neurological Differential Diagnosis is a streamlined handbook of prioritized differential diagnosis, to be used both in clinical practice and for exam review. By presenting differential diagnosis in order of frequency and importance, this book provides a practical handbook for clinicians in training, as well as a potential resource for quick board review. Whilst the book covers the most important syndromes and disease entities, readers are referred to other texts for more exhaustive differentials. By limiting differentials in this way – to the most likely and most serious diagnoses – the reader can more easily recall relevant disease processes when faced with a particular clinical situation, whether it be a patient in the emergency room or a difficult question on the board examination. The book specifically targets neurology residents and fellows, with overlap to neurosurgery and psychiatry. Internal medicine physicians with an interest in neurological problems and medical students looking for an edge in clinical neuroscience would also benefit from this text. The content is primarily mid-level material, in a pedagogic format. In order to organize the students' thought processes concise tables and line drawing templates are included. The book is organized into broad chapters by type of disorder and some overlap occurs between particular chapters.
This book was born from the synthesis of the rapidly proliferating field of cerebrovascular disease research, excitement about effective new imaging and therapeutic strategies, and the need to timely educate clinicians about the changing playing field for a common, serious and expensive syndrome – transient ischemic attacks (TIA). TIAs can now stand on their own as an important, and, at times, unique aspect of symptomatic cerebrovascular disease, distinct enough to warrant a textbook in its own right. With new information on a worrisome and serious natural history, growing knowledge of risk factors and their management, sophisticated neuroimaging techniques, and a broadening armamentarium of therapeutic approaches, the clinician is now faced with multiple levels of decision making. Does one admit the patient with a recent TIA to the hospital? What are the optimal imaging and diagnostic strategies? What antiplatelet agent to use? What is the role for surgery and interventional techniques? How do I optimally control associated risk factors? This book serves to provide the most current information to help guide clinicians through the best decisions to care for their patients, using evidence-based recommendations when available and expert opinion when no good data exist.
In Evidence-based Neurology: Management of Neurological Disorders a carefully selected group of clinically experienced collaborators use the best available evidence to answer more than 100 clinical questions about the treatment and management of neurological disorders. Divided into three sections and 24 chapters, this book fills the gap between guidelines and primary studies as well as between primary and secondary scientific medical literature summarizes the most recent and important findings on treatments for neurological patients measures the benefit and, when applicable, the risk of harm inherent in specific neurological interventions. This unique, evidence-based text, edited by members of the Cochrane Neurological Network will be an essential resource for all general neurologists, from the novice to the most experienced, in their everyday clinical practice.
Based on the highly acclaimed Sleep: A Comprehensive Handbook, this is a concise, convenient, practical, and affordable handbook on sleep medicine. It consists of forty topic-focused chapters written by a panel of international experts covering a range of topics including insomnia, sleep apnea, narcolepsy, parasomnias, circadian sleep disorders, sleep in the elderly, sleep in children, sleep among women, and sleep in the medical, psychiatric, and neurological disorders. It serves as an effective Sleep Medicine board examination review, and every chapter includes sample boards -style questions for test preparation and practice.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.