Медицина
Различные книги в жанре МедицинаSystems Biology in Drug Discovery and Development
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
Tissue and Cell Clinical Use. An Essential Guide
This new book explores clinical information in the tissue transplantation field and acts as a comprehensive learning tool to comply with regulatory requirements. Broad in scope, coverage includes all the traditionally transplanted tissues and moves into more complex areas of tissue grafting and the assisted reproduction fields. This useful text focuses on the potential for disease transmission, ways to improve safety, and the role of the clinician in these safety aspects. The book starts off by describing non-surgical risks of using allografts and moves onto chapters devoted completely to tissue- or cell-specific issues relating to transplantation of the individual types of tissues or cells. Tissue and Cell Clinical Use: An Essential Guide is the final book in a series which covers all aspects of tissue banking, donation, processing, and transplantation. Each book in the series includes lists of learning points and case studies which consist of sample processing protocols, descriptions of where processing went wrong, sample risk assessments, or validation studies. This three book series covers all you need to know about tissue banking.
Thermodynamics of Pharmaceutical Systems. An introduction to Theory and Applications
Designed for pharmacy students Now updated for its Second Edition, Thermodynamics of Pharmaceutical Systems provides pharmacy students with a much-needed introduction to the mathematical intricacies of thermodynamics in relation to practical laboratory applications. Designed to meet the needs of the contemporary curriculum in pharmacy schools, the text makes these connections clear, emphasizing specific applications to pharmaceutical systems including dosage forms and newer drug delivery systems. Students and practitioners involved in drug discovery, drug delivery, and drug action will benefit from Connors' and Mecozzi's authoritative treatment of the fundamentals of thermodynamics as well as their attention to drug molecules and experimental considerations. They will appreciate, as well, the significant revisions to the Second Edition. Expanding the book's scope and usefulness, the new edition: Explores in greater depth topics most relevant to the pharmacist such as drug discovery and drug delivery, supramolecular chemistry, molecular recognition, and nanotechnologies Moves the popular review of mathematics, formerly an appendix, to the front of the book Adds new textual material and figures in several places, most notably in the chapter treating noncovalent chemical interactions Two new appendices provide ancillary material that expands on certain matters bordering the subject of classical thermodynamics Thermodynamics need not be a mystery nor confined to the realm of mathematical theory. Thermodynamics of Pharmaceutical Systems, Second Edition demystifies for students the profound thermodynamic applications in the laboratory while also serving as a handy resource for practicing researchers.
Orofacial Pain. A Guide to Medications and Management
Orofacial Pain: A Guide to Medications and Management brings together guidance and information on the rational use of medications for the treatment of chronic orofacial pain. Focusing on clinically relevant information throughout and aiming itself squarely at the needs of dentists and other clinicians working directly with orofacial pain, the book covers the use of oral, injectable and topical medications for managing neuropathic and musculoskeletal pain, headache, and uncommon orofacial pain disorders. Useful features, such as discussion of the top 60 medications prescribed for orofacial pain, are integrated with comprehensive coverage of drug types, pharmacolegal issues, and the interaction of medication management with other treatment strategies.
Rapid Paediatrics and Child Health
This pocket reference and revision guide is a must for all medical students and junior doctors preparing for major exams in paediatrics and child health or needing a rapid reminder during a clinical attachment. Now thoroughly updated and with the addition of key references, this new edition provides quick access to information on common paediatric problems and disorders, their signs, symptoms, and aetiological agents. It includes sections on surgical problems, procedures, and general paediatric management such as resuscitation techniques, and features tips on how to take a paediatric history. It presents the contents ordered by system and conditions in alphabetical order, reflects current NICE and paediatric surgery guidelines, and features over 15 new presentations including eczema, food allergies and conduct disorder.
Innate Immune System of Skin and Oral Mucosa. Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products
An in-depth look at cutting-edge research on the body's innate immune system Innate immunity is the body's first line of protection against potential microbial, viral, and environmental attacks, and the skin and oral mucosa are two of the most powerful barriers that which we rely on to stay well. The definitive book on the subject, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview of these systems, including coverage of antimicrobial peptides and lipids and microbial challenges and stressors that can influence innate immunity. Designed to help experts and newcomers alike in fields like dermatology, oral pathology, cosmetics, personal care, and pharmaceuticals, the book is filled with suggestions to assist research and development. Looking at the many challenges facing the innate immune system, including the impact of topically applied skin products and medications, Innate Immune System of Skin and Oral Mucosa paves the way for next generation treatment avenues, preventative approaches, and drug development.
How to Present at Meetings
Does the thought of presenting a paper make you go cold? There are so many things to consider: getting your message across clearly, making the PowerPoint easy to read, keeping to the right length and keeping the audience riveted – enough to induce nerves even without the thought of standing up in front of a crowd and delivering your talk fluently. How to Present at Meetings, 3rd Edition, gives you practical advice on all these aspects, and more. Written by high-profile public speakers in the health sciences, it includes chapters on the 10-, 20- and 45-minute presentation, how not to make a mess of PowerPoint, and how to appear on stage.
Race, Ethnicity, and Health. A Public Health Reader
Race, Ethnicity and Health, Second Edition, is a new and critical selection of hallmark articles that address health disparities in America. It effectively documents the need for equal treatment and equal health status for minorities. Intended as a resource for faculty and students in public health as well as the social sciences, it will be also be valuable to public health administrators and frontline staff who serve diverse racial and ethnic populations. The book brings together the best peer reviewed research literature from the leading scholars and faculty in this growing field, providing a historical and political context for the study of health, race, and ethnicity, with key findings on disparities in access, use, and quality. This volume also examines the role of health care providers in health disparities and discusses the issue of matching patients and doctors by race. There has been considerable new research since the original manuscript’s preparation in 2001 and publication in 2002, and reflecting this, more than half the book is new content. New chapters cover: reflections on demographic changes in the US based on the current census; metrics and nomenclature for disparities; theories of genetic basis for disparities; the built environment; residential segregation; environmental health; occupational health; health disparities in integrated communities; Latino health; Asian populations; stress and health; physician/patient relationships; hospital treatment of minorities; the slavery hypertension hypothesis; geographic disparities; and intervention design.
Essential Guide to Blood Coagulation
A practical guide to laboratory diagnosis and treatment of hemostatic disorders. This concise book covers all you need to know to manage thrombotic and bleeding disorders, distilling the most clinically up-to-date information, and including the latest treatment strategies for key conditions and diseases. Essential Guide to Blood Coagulation covers both the stable and the acute stages of hereditary and acquired bleeding and thrombotic disorders. Faced with a bleeding patient, it may be difficult to determine whether blood loss is due to a local factor or an underlying hemostatic defect. There are a range of laboratory tests which can be performed to identify the cause of bleeding in a patient. This book highlights the tests that can be used in the laboratory to aid diagnosis. Originally published in Swedish, Essential Guide to Blood Coagulation, has been revised to include the latest treatment strategies available for patients and will help clinicians to expand their knowledge of hemostatic disorders.
RNA Interference. Application to Drug Discovery and Challenges to Pharmaceutical Development
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.