Spectrums of Amyotrophic Lateral Sclerosis. Группа авторов

213

      Spectrums of Amyotrophic Lateral Sclerosis

      Heterogeneity, Pathogenesis and Therapeutic Directions

      EDITED BY

      Christopher A. Shaw and Jessica R. Morrice

      University of British Columbia, Canada

      This edition first published 2021

      © 2021 John Wiley & Sons Ltd

      All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

      The right of Christopher A. Shaw and Jessica R. Morrice to be identified as the authors of the editorial material in this work has been asserted in accordance with law.

      Registered Offices John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

      Editorial Office 9600 Garsington Road, Oxford, OX4 2DQ, UK

      For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

      Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.

      Limit of Liability/Disclaimer of Warranty While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

       Library of Congress Cataloging‐in‐Publication Data

      Names: Shaw, Christopher A. (Christopher Ariel), editor. | Morrice, Jessica R., editor.

      Title: Spectrums of amyotrophic lateral sclerosis : heterogeneity, Pathogenesis and therapeutic directions / edited by Christopher A. Shaw and Jessica R. Morrice.

      Description: Hoboken, NJ : Wiley-Blackwell, 2021. | Includes bibliographical references and index.

      Identifiers: LCCN 2021003406 (print) | LCCN 2021003407 (ebook) | ISBN 9781119745495 (hardback) | ISBN 9781119745501 (adobe pdf) | ISBN 9781119745518 (epub)

      Subjects: MESH: Amyotrophic Lateral Sclerosis–genetics | Amyotrophic Lateral Sclerosis–drug therapy | Genetic Heterogeneity | Spectrum Analysis | Models, Genetic

      Classification: LCC RC406.A24 (print) | LCC RC406.A24 (ebook) | NLM WE 552 | DDC 616.8/39–dc23

      LC record available at https://lccn.loc.gov/2021003406 LC ebook record available at https://lccn.loc.gov/2021003407

      Cover Design: Wiley

      Cover Image: © Emma McEachern

       This book is dedicated to people living with ALS, their families, and those who care for them.

Contributors

      Christen G. Chisholm, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia

      Roger S. Chung, Motor Neuron Disease Research Centre, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia

      Robert A. Déziel, CNS Contract Research Corp, Charlottetown, Prince Edward Island, Canada

      Patrick A. Dion, Montreal Neurological Institute and Hospital, McGill University, Montréal, Québec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada

      Angela Genge, Montreal Neurological Institute and Hospital, Montréal, Québec, Canada

      Daphne A. Gill, CNS Contract Research Corp, Charlottetown, Prince Edward Island, Canada; Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada

      Manuel Graeber, Brain Tumor Research Laboratories, Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia

      Cheryl Y. Gregory‐Evans, Experimental Medicine Program, University of British Columbia, Vancouver, British Columbia, Canada; Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada; Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada

      Denis G. Kay, Alpha Cognition Inc., Charlottetown, Prince Edward Island, Canada

      Charles Krieger, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Division of Neurology, Vancouver Coastal Health, Vancouver, British Columbia, Canada

      Michael Kuo, Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada

Audrey Labarre, Department of Neuroscience, University of Montréal, Montréal, Québec, Canada; Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada

      Serena Lattante, Unità Operativa Complessa di Genetica Medica, Dipartimento di Scienze di Laboratorio e Infettivologico, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

      Albert Lee, Motor Neuron